scholarly journals RIGHT VS. LEFT TEMPORAL LOBE SEMIOLOGY IN DEMENTIA: LESSONS FROM TWO CASES WITH FOCAL FRONTOTEMPORAL DEMENTIA SYNDROMES

2021 ◽  
Author(s):  
Vitor Arca ◽  
Pedro Albuquerque ◽  
Victor Correia ◽  
Amanda Pires ◽  
Hugo Araújo ◽  
...  
Keyword(s):  
Frontotemporal Dementia ◽  
Temporal Lobe ◽  
Word Processing ◽  
Brain Mri ◽  
Cerebral Atrophy ◽  
Primary Progressive Aphasia ◽  
Left Temporal Lobe ◽  
Her Family ◽  
Mini Mental Status Examination ◽  
The Right

Background: Case 1: a 59-year old man presented to our service with 4 years of progressive cognitive and behavioral symptoms. He became forgetful and experienced difficulties managing his payments. After 4 years he could no longer recognise his relatives. Cognitive assessment showed a mini-mental status examination of 17/30. MRI and SPECT revealed respectively focal atrophy and hipoperfusion of the frontal regions and anterior right temporal lobe. Case 2: a 72-year-old woman was brought to evaluation with a 5-years history of progressive language and behavioral deterioration. Her family reported early speech errors and behavioral changes, with a marked aggressiveness, ritualistic behaviors and hyperorality. Cognitive evaluation revealed a MMSE of 6/30 mainly due to a relatively fluent afasia. Brain MRI showed asymmetric cerebral atrophy, more prominent in the anterior left temporal lobe. Objective: N/H Methods: N/H Results: N/H Conclusion: We describe two cases of suspected frontotemporal dementia (FTD) syndromes. The left ATL may receive proportionately more input from the lexical and phonological centers subserving word processing. The right ATL may receive more input from right-lateralized emotion processing hubs. Focal atrophy of the left anterior temporal lobe has been associated with the semantic type of primary progressive aphasia evolving to semantic dementia. In contrast, focal atrophy of the right temporal lobe has recently been described as a controversial entity reported as the right temporal variant of FTD.

Damage of left temporal lobe resulting in conversion of speech to Sutra, a Buddhist prayer stored in the right hemisphere

Neurocase ◽  
2010 ◽  
Vol 16 (4) ◽  
pp. 317-320 ◽  
Author(s):  
Nobusada Shinoura ◽  
Toshiyuki Onodera ◽  
Kotoyo Kurokawa ◽  
Masanobu Tsukada ◽  
Ryozi Yamada ◽  
...  
Keyword(s):  
Temporal Lobe ◽  
Right Hemisphere ◽  
Left Temporal Lobe ◽  
The Right

scholarly journals Right temporal variant frontotemporal dementia is pathologically heterogeneous: a case-series and a systematic review

2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Hulya Ulugut ◽  
Anke A. Dijkstra ◽  
Marta Scarioni ◽  
Frederik Barkhof ◽  
Philip Scheltens ◽  
...  
Keyword(s):  
Systematic Review ◽  
Frontotemporal Dementia ◽  
Case Series ◽  
Primary Progressive Aphasia ◽  
General Assumption ◽  
Large Sample Size ◽  
Pathological Evaluation ◽  
Type C ◽  
The Right ◽  
Underlying Pathology

AbstractAlthough the right temporal variant frontotemporal dementia (rtvFTD) is characterised by distinct clinical and radiological features, its underlying histopathology remains elusive. Being considered a right-sided variant of semantic variant primary progressive aphasia (svPPA), TDP-43 type C pathology has been linked to the syndrome, but this has not been studied in detail in large cohorts. In this case report and systematic review, we report the autopsy results of five subjects diagnosed with rtvFTD from our cohort and 44 single rtvFTD subjects from the literature. Macroscopic pathological evaluation of the combined results revealed that rtvFTD demonstrated either a frontotemporal or temporal evolution, even if the degeneration started in the right temporal lobe initially. FTLD-TDP type C was the most common underlying pathology in rtvFTD, however, in 64% of rtvFTD, other underlying pathologies than FTLD-TDP type C were present, such as Tau-MAPT and FTLD-TDP type A and B. Additionally, accompanying motor neuron or corticospinal tract degeneration was observed in 28% of rtvFTD patients. Our results show that in contrast to the general assumption, rtvFTD might not be a pure FTLD-TDP type C disorder, unlike its left temporal counterpart svPPA. Large sample size pathological studies are warranted to understand the diverse pathologies of the right and left temporal variants of frontotemporal dementia.

scholarly journals ML-4 A case of primary CNS lymphoma diagnosed 5 years after stereotactic radiosurgery

2021 ◽  
Vol 3 (Supplement_6) ◽  
pp. vi23-vi23
Author(s):  
Yusuke Tabei ◽  
Ichirou Nakazato ◽  
Kenichi Ooyama ◽  
Masatou Kawashima ◽  
Akira Matsuno ◽  
...  
Keyword(s):  
Brain Metastases ◽  
Stereotactic Radiosurgery ◽  
Tumor Cells ◽  
Temporal Lobe ◽  
Radiation Necrosis ◽  
B Cell Lymphoma ◽  
Unknown Primary ◽  
High Dose ◽  
Left Temporal Lobe ◽  
The Right

Abstract Central nervous system primary malignant lymphoma (PCNSL) is rarely diagnosed as multiple metastatic brain tumors. Almost tumors recure early after receiving stereotactic radiosurgery (SRS). Regardless of the fact, the following case report displays PCNSL, diagnosed five years after the initial treatment with SRS as brain metastases of unknown primary origin. This extraordinal case suggests long-term follow-up regarding PCNCL. The case was a 55-year-old woman with a history of a total hysterectomy for cervical cancer. She developed left paralysis. Brain MRI confirmed a 27 mm contrast-enhanced lesion in the right frontal lobe and three other lesions. SRS was performed as a diagnosis of multiple brain metastases for urgent symptom relief. No extra-cranial cancerous lesions were found. Unknown primary cancer was a probable diagnosis at that time. Two years after SRS, local regrowth of tumor of the right frontal primary motor area was discovered. Re-irradiation was performed. Cerebral edema, contrast enhancement, and left paralysis progressed following five months, taking an oral corticosteroid. Craniotomy and debulk. The pathological diagnosis was brain radiation necrosis due to no viable tumor cells. New lesions in the left temporal lobe and basal ganglia appeared three years after surgery. Awake craniotomy was performed for the left temporal lobe lesion. Histopathology showed diffuse growth of tumor cells with a high nucleo-cytoplasmic ratio and irregular nuclear shape. Immunohistochemistry revealed positive CD10, CD20, CD45 (LCA), MUM1, and negative CD3, CD5. The Ki- 67 labeling rate was as high as almost 100% to diagnose diffuse large B-cell lymphoma, PCNSL. Multidrug chemotherapy consisting of rituximab, high-dose methotrexate, procarbazine, and vincristine were performed. Complete remission was obtained without any serious adverse events. Considering the residual radiation necrosis, whole-brain irradiation was avoided. Moreover, consolidation therapy was performed only with high-dose cytarabine therapy.

Perception of Geometrical Figures in Persons with Damaged Temporal Lobes

Perception ◽  
1997 ◽  
Vol 26 (1_suppl) ◽  
pp. 244-244
Author(s):  
R Lukauskiene ◽  
A Bertulis ◽  
I Busauskiene ◽  
B Mickiene
Keyword(s):  
Visual Field ◽  
Temporal Lobe ◽  
Spatial Neglect ◽  
Right Visual Field ◽  
Size Discrimination ◽  
Left Temporal Lobe ◽  
Form Discrimination ◽  
Temporal Lobes ◽  
The Right ◽  
Better Than

Persons with damaged temporal lobes were tested with computerised tests for size and form discrimination developed by A Bulatov and A Bertulis (1994 Perception23 Supplement, 25). 48 persons with damaged right and 54 persons with damaged left temporal lobe were tested. 8 persons showed hemineglect of the right visual field and 10 persons hemineglect of the left visual field. Posner (1987 Neuropsychologia25 135) stated that persons with unilateral spatial neglect had a specific inability to disengage their attention from a given object in order to reallocate it to another object positioned to its left or right. In our studies we determined whether size discrimination abnormalities also occur in the neglected side, opposite to the damaged temporal lobe. We estimated the accuracy with which subjects judged the height of two squares of different colours. Two squares with sizes varying from 0.2 to 3.0 deg were generated on the right and left side of the monitor. Subjects viewed the patterns binocularly at a distance of 1 m and adjusted the size of the square on the left to make its height equal to that on the right. The error of the setting was recorded. Persons with hemineglect of the visual field were unable to concentrate their attention at two figures located on both sides of the monitor so they were unable to make the comparison. Persons with right and left temporal lobe damage without hemineglect of the visual field judged the geometrical figures better than those with hemineglect but worse than controls. Persons with damaged left temporal lobe judged figures less well than persons with damaged right temporal lobe.

scholarly journals The right temporal lobe variant of frontotemporal dementia

2006 ◽  
Vol 253 (11) ◽  
pp. 1447-1458 ◽  
Author(s):  
Sven Joubert ◽  
Olivier Felician ◽  
Emmanuel Barbeau ◽  
Jean-Philippe Ranjeva ◽  
Marion Christophe ◽  
...  
Keyword(s):  
Frontotemporal Dementia ◽  
Temporal Lobe ◽  
The Right

scholarly journals Words and objects at the tip of the left temporal lobe in primary progressive aphasia

Brain ◽  
2013 ◽  
Vol 136 (2) ◽  
pp. 601-618 ◽  
Author(s):  
M.-Marsel Mesulam ◽  
Christina Wieneke ◽  
Robert Hurley ◽  
Alfred Rademaker ◽  
Cynthia K. Thompson ◽  
...  
Keyword(s):  
Temporal Lobe ◽  
Primary Progressive Aphasia ◽  
Left Temporal Lobe ◽  
Progressive Aphasia ◽  
Primary Progressive

Hyper-religiosity in frontotemporal dementia with predominant atrophy of the right temporal lobe

2020 ◽  
pp. practneurol-2020-002755
Author(s):  
Maria Karatzikou ◽  
Theodora Afrantou ◽  
Dimitrios Parissis ◽  
Panagiotis Ioannidis
Keyword(s):  
Frontotemporal Dementia ◽  
Temporal Lobe ◽  
The Right

Brain activation on fMRI and verbal memory ability: Functional neuroanatomic correlates of CVLT performance

2001 ◽  
Vol 7 (1) ◽  
pp. 55-62 ◽  
Author(s):  
STERLING C. JOHNSON ◽  
ANDREW J. SAYKIN ◽  
LAURA A. FLASHMAN ◽  
THOMAS W. McALLISTER ◽  
MOLLY B. SPARLING
Keyword(s):  
Temporal Lobe ◽  
Verbal Memory ◽  
Medial Temporal Lobe ◽  
Word Processing ◽  
Right Hemisphere ◽  
Verbal Learning ◽  
Clinical Test ◽  
Memory Ability ◽  
The Right ◽  
Novel Words

We have recently reported (Saykin et al., 1999b) selective activation of left medial temporal lobe structures during processing of novel compared to familiar words using functional magnetic resonance imaging (fMRI). The current study describes the relationship between a widely used clinical test of verbal learning, the California Verbal Learning Test (CVLT), and the previously reported fMRI activations. Thirteen right-handed healthy adult participants were studied with whole brain echo-planar fMRI while listening to novel and recently learned (familiar) words intermixed pseudorandomly in an event-related design. These participants were also tested with the CVLT. Scores for CVLT Trial 1 (immediate encoding of novel words) and recognition discriminability (recognition of familiar vs. novel words) were correlated with fMRI signal change during processing of novel versus familiar words using a covariance model implemented in SPM96. For the novel words analysis, voxels in the right anterior hippocampus correlated significantly with Trial 1 (r = .76 at the maxima). For the recognition analysis, a significant cluster of voxels was found in the right dorsolateral prefrontal cortex (r = .88 at the maxima). Our prior results of separable left medial temporal activation to novel and familiar words, together with results of the covariance analyses reported here, suggest that in addition to the left medial temporal lobe (MTL) regions that are engaged during novel and familiar word processing, the right hippocampus and right frontal lobe are also involved, particularly in those participants with better memory ability. This positive relationship between fMRI activation and CVLT performance suggests a role for these right hemisphere regions in successful memory processing of verbal material, perhaps reflecting more efficient encoding and retrieval strategies that facilitate memory. (JINS, 2001, 7, 55–62.)

scholarly journals Multiorgan thrombosis as a complication of COVID-19 pneumonia

2021 ◽  
Vol 14 (7) ◽  
pp. e243953
Author(s):  
Etienne Ceci Bonello ◽  
Ramon Casha ◽  
Thelma Xerri ◽  
John Bonello ◽  
Claudia Fsadni ◽  
...  
Keyword(s):  
Temporal Lobe ◽  
Brain Mri ◽  
Occipital Lobe ◽  
Neurological Complications ◽  
Left Ventricular ◽  
Mural Thrombus ◽  
Left Temporal Lobe ◽  
Rehabilitation Centre ◽  
Coronary Syndrome ◽  
Midline Sternotomy

A 47-year-old man, positive for SARS-CoV-2, was diagnosed with acute coronary syndrome (ACS) complicated by myocarditis on a background of COVID-19 pneumonia. He was medically treated for ACS; however, 3 days into his admission, the patient developed neurological complications confirmed on MRI of the brain. MRI showed established infarcts involving a large part of the left temporal lobe and right occipital lobe, with minor foci of micro-haemorrhagic transformation in the left temporal lobe. A left ventricular mural thrombus was then confirmed on echocardiogram, and this was attributed as the cause of his neurological infarct. Further infarctions in the kidneys and spleen, and thrombi in the superior mesenteric and left femoral artery were also identified on imaging of the abdomen. The left ventricular mural thrombus was removed surgically via a midline sternotomy incision under general anaesthesia. Surgery was successful and the patient was discharged to a rehabilitation centre.

NIMG-34. DELAYED PSEUDOPROGRESSION IN GLIOBLASTOMA PATIENTS TREATED WITH TTFIELDS: A REPORT OF TWO CASES

2021 ◽  
Vol 23 (Supplement_6) ◽  
pp. vi136-vi136
Author(s):  
Norihiko Saito ◽  
Nozomi Hirai ◽  
Akinori Yagihashi ◽  
Shusaku Takahagi ◽  
Naoki Kushida ◽  
...  
Keyword(s):  
Temporal Lobe ◽  
Radiographic Progression ◽  
Cell Membrane Permeability ◽  
Newly Diagnosed ◽  
Left Temporal Lobe ◽  
Phase 3 ◽  
Tumor Treating Fields ◽  
Specific Effects ◽  
The Right

Abstract INTRODUCTION: Tumor treating fields (TTFields) is an established treatment modality for glioblastoma (GBM) and is administered with the portable Optune system. Although the EF-14 phase 3 trial demonstrated the efficacy of TTFields for newly diagnosed GBM, uncertainty regarding the specific effects of this treatment has prevented its widespread clinical use. Pseudoprogression in response to chemoradiation is a known problem in GBM patients and most commonly occurs within 3 months after radiotherapy. We report 2 cases of TTFields delayed pseudoprogression. CASE REPORT: Two GBM patients being treated with TTFields showed signs of radiographic progression at 5 to 6 months after completing radiotherapy. Patient 1 was a 37-year-old woman with gliosarcoma in the right temporal lobe. Patient 2 was a 70-year-old man with wildtype-IDH GBM in the left temporal lobe. Both patients received TTFields in addition to maintenance temozolomide (TMZ) after radiotherapy (RT). Radiographic progression was noted at 5 and 6 months after RT in Patients 1 and 2, respectively. Second resections were performed, and pathology showed only the treatment effect, which ultimately led to diagnosis of pseudoprogression. DISCUSSION: Both patients had radiographic progression outside the typical pseudoprogression window. Recent studies reported that TTFields increased plasma cell membrane permeability, which could result in additional gadolinium leakage into the extracellular space. CONCLUSIONS: Better characterization of delayed pseudoprogression would improve treatment and could potentially reduce unnecessary surgeries and discontinuation of successful therapies.

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