Damage of left temporal lobe resulting in conversion of speech to Sutra, a Buddhist prayer stored in the right hemisphere

Neurocase ◽  
2010 ◽  
Vol 16 (4) ◽  
pp. 317-320 ◽  
Author(s):  
Nobusada Shinoura ◽  
Toshiyuki Onodera ◽  
Kotoyo Kurokawa ◽  
Masanobu Tsukada ◽  
Ryozi Yamada ◽  
...  
Keyword(s):  
Temporal Lobe ◽  
Right Hemisphere ◽  
Left Temporal Lobe ◽  
The Right

scholarly journals Neuroplasticity of language in left-hemisphere stroke: evidence linking subsecond electrophysiology and structural connections

2016 ◽  
Author(s):  
Vitória Piai ◽  
Lars Meyer ◽  
Nina F. Dronkers ◽  
Robert T. Knight
Keyword(s):  
Temporal Lobe ◽  
Language Processing ◽  
Time Course ◽  
Right Hemisphere ◽  
Structural Connectivity ◽  
Left Temporal Lobe ◽  
Beta Power ◽  
Oscillatory Power ◽  
Alpha Beta ◽  
The Right

AbstractOur understanding of neuroplasticity following stroke is predominantly based on neuroimaging measures that cannot address the subsecond neurodynamics of impaired language processing. We combined behavioral and electrophysiological measures and structural-connectivity estimates to characterize neuroplasticity underlying successful compensation of language abilities after left-hemispheric stroke. We recorded the electroencephalogram from patients with stroke lesions to the left temporal lobe and matched controls during context-driven word retrieval. Participants heard lead-in sentences that either constrained the final word (“He locked the door with the”) or not (“She walked in here with the”). The last word was shown as a picture to be named. We conducted individual-participant analyses and focused on oscillatory power as a subsecond indicator of a brain region's functional neurophysiological computations. All participants named pictures faster following constrained than unconstrained sentences, except for two patients, who had extensive damage to the left temporal lobe. Left-lateralized alpha-beta oscillatory power decreased in controls pre-picture presentation for constrained relative to unconstrained contexts. In patients, the alpha-beta power decreases were observed with the same time course as in controls but were lateralized to the intact right hemisphere. The right lateralization depended on the probability of white-matter connections between the bilateral temporal lobes. The two patients who performed poorly behaviorally showed no alpha-beta power decreases. Our findings suggest that incorporating direct measures of neural activity into investigations of neuroplasticity can provide important neural markers to help predict language recovery, assess the progress of neurorehabilitation, and delineate targets for therapeutic neuromodulation.

scholarly journals Localization of Syntactic and Semantic Brain Responses using Magnetoencephalography

2007 ◽  
Vol 19 (7) ◽  
pp. 1193-1205 ◽  
Author(s):  
Elisabet Service ◽  
Päivi Helenius ◽  
Sini Maury ◽  
Riitta Salmelin
Keyword(s):  
Temporal Lobe ◽  
Semantic Processing ◽  
Sentence Comprehension ◽  
Right Hemisphere ◽  
Temporal Cortex ◽  
Word Class ◽  
Sentence Reading ◽  
Word Onset ◽  
Semantic Errors ◽  
The Right

Electrophysiological methods have been used to study the temporal sequence of syntactic and semantic processing during sentence comprehension. Two responses associated with syntactic violations are the left anterior negativity (LAN) and the P600. A response to semantic violation is the N400. Although the sources of the N400 response have been identified in the left (and right) temporal lobe, the neural signatures of the LAN and P600 have not been revealed. The present study used magnetoencephalography to localize sources of syntactic and semantic activation in Finnish sentence reading. Participants were presented with sentences that ended in normally inf lected nouns, nouns in an unacceptable case, verbs instead of nouns, or nouns that were correctly inflected but made no sense in the context. Around 400 msec, semantically anomalous last words evoked strong activation in the left superior temporal lobe with significant activation also for word class errors (N400). Weaker activation was seen for the semantic errors in the right hemisphere. Later, 600-800 msec after word onset, the strongest activation was seen to word class and morphosyntactic errors (P600). Activation was significantly weaker to semantically anomalous and correct words. The P600 syntactic activation was localized to bilateral sources in the temporal lobe, posterior to the N400 sources. The results suggest that the same general region of the superior temporal cortex gives rise to both LAN and N400 with bilateral reactivity to semantic manipulation and a left hemisphere effect to syntactic manipulation. The bilateral P600 response was sensitive to syntactic but not semantic factors.

Right hemisphere speech perception revealed by amobarbital injection and electrical interference

Neurology ◽  
1998 ◽  
Vol 51 (2) ◽  
pp. 458-464 ◽  
Author(s):  
D. Boatman ◽  
J. Hart ◽  
R. P. Lesser ◽  
N. Honeycutt ◽  
N. B. Anderson ◽  
...  
Keyword(s):  
Speech Perception ◽  
Left Hemisphere ◽  
Temporal Lobe ◽  
Right Hemisphere ◽  
Adult Brain ◽  
Left Posterior ◽  
Left And Right ◽  
Sodium Amobarbital ◽  
The Right ◽  
Electrical Interference

Objective: To investigate the right hemispheric speech perception capabilities of an adult right-handed patient with seizures.Methods: Consecutive, unilateral, intracarotid sodium amobarbital injections and left hemispheric electrical interference mapping were used to determine lateralization and localization of speech perception, measured as syllable discrimination.Results: Syllable discrimination remained intact after left and right intracarotid sodium amobarbital injections. Language otherwise strongly lateralized to the left hemisphere. Despite evidence of bilateral speech perception capabilities, electrical interference testing in the left posterior temporal lobe impaired syllable discrimination.Conclusions: The results suggest a functionally symmetric, parallel system in the adult brain with preferential use of left hemispheric pathways for speech perception.

Musical Perception and Cerebral Function: A Critical Review

1984 ◽  
Vol 2 (2) ◽  
pp. 196-221 ◽  
Author(s):  
Robert J. Zatorre
Keyword(s):  
Left Hemisphere ◽  
Temporal Lobe ◽  
Critical Review ◽  
Right Hemisphere ◽  
Musical Performance ◽  
Cerebral Function ◽  
Musical Perception ◽  
The Right

A critical review is provided of the literature on musical performance following intracarotid sodium Amytal injection and on studies of musical perception in groups of unilaterally brain-damaged persons. The sodium Amytal data suggest that both hemispheres are active in singing familiar songs, since injection into either hemisphere produces disruption of singing. Studies with brain-damaged populations generally find deficits after right-sided damage in tasks demanding processing of patterns of pitches (e. g., unfamiliar melodic sequences) as well as with differences in timbre. Damage to the right temporal lobe causes the most consistent deficits in these tasks. Damage to the left side does not impair performance on such tasks, but does cause problems when familiar tunes are involved, especially if naming or identification is required, regardless of the presence or absence of aphasia. Damage to the right hemisphere also affects performance in such cases, but not usually to the extent that left-hemisphere lesions do.

scholarly journals ML-4 A case of primary CNS lymphoma diagnosed 5 years after stereotactic radiosurgery

2021 ◽  
Vol 3 (Supplement_6) ◽  
pp. vi23-vi23
Author(s):  
Yusuke Tabei ◽  
Ichirou Nakazato ◽  
Kenichi Ooyama ◽  
Masatou Kawashima ◽  
Akira Matsuno ◽  
...  
Keyword(s):  
Brain Metastases ◽  
Stereotactic Radiosurgery ◽  
Tumor Cells ◽  
Temporal Lobe ◽  
Radiation Necrosis ◽  
B Cell Lymphoma ◽  
Unknown Primary ◽  
High Dose ◽  
Left Temporal Lobe ◽  
The Right

Abstract Central nervous system primary malignant lymphoma (PCNSL) is rarely diagnosed as multiple metastatic brain tumors. Almost tumors recure early after receiving stereotactic radiosurgery (SRS). Regardless of the fact, the following case report displays PCNSL, diagnosed five years after the initial treatment with SRS as brain metastases of unknown primary origin. This extraordinal case suggests long-term follow-up regarding PCNCL. The case was a 55-year-old woman with a history of a total hysterectomy for cervical cancer. She developed left paralysis. Brain MRI confirmed a 27 mm contrast-enhanced lesion in the right frontal lobe and three other lesions. SRS was performed as a diagnosis of multiple brain metastases for urgent symptom relief. No extra-cranial cancerous lesions were found. Unknown primary cancer was a probable diagnosis at that time. Two years after SRS, local regrowth of tumor of the right frontal primary motor area was discovered. Re-irradiation was performed. Cerebral edema, contrast enhancement, and left paralysis progressed following five months, taking an oral corticosteroid. Craniotomy and debulk. The pathological diagnosis was brain radiation necrosis due to no viable tumor cells. New lesions in the left temporal lobe and basal ganglia appeared three years after surgery. Awake craniotomy was performed for the left temporal lobe lesion. Histopathology showed diffuse growth of tumor cells with a high nucleo-cytoplasmic ratio and irregular nuclear shape. Immunohistochemistry revealed positive CD10, CD20, CD45 (LCA), MUM1, and negative CD3, CD5. The Ki- 67 labeling rate was as high as almost 100% to diagnose diffuse large B-cell lymphoma, PCNSL. Multidrug chemotherapy consisting of rituximab, high-dose methotrexate, procarbazine, and vincristine were performed. Complete remission was obtained without any serious adverse events. Considering the residual radiation necrosis, whole-brain irradiation was avoided. Moreover, consolidation therapy was performed only with high-dose cytarabine therapy.

scholarly journals RIGHT VS. LEFT TEMPORAL LOBE SEMIOLOGY IN DEMENTIA: LESSONS FROM TWO CASES WITH FOCAL FRONTOTEMPORAL DEMENTIA SYNDROMES

2021 ◽  
Author(s):  
Vitor Arca ◽  
Pedro Albuquerque ◽  
Victor Correia ◽  
Amanda Pires ◽  
Hugo Araújo ◽  
...  
Keyword(s):  
Frontotemporal Dementia ◽  
Temporal Lobe ◽  
Word Processing ◽  
Brain Mri ◽  
Cerebral Atrophy ◽  
Primary Progressive Aphasia ◽  
Left Temporal Lobe ◽  
Her Family ◽  
Mini Mental Status Examination ◽  
The Right

Background: Case 1: a 59-year old man presented to our service with 4 years of progressive cognitive and behavioral symptoms. He became forgetful and experienced difficulties managing his payments. After 4 years he could no longer recognise his relatives. Cognitive assessment showed a mini-mental status examination of 17/30. MRI and SPECT revealed respectively focal atrophy and hipoperfusion of the frontal regions and anterior right temporal lobe. Case 2: a 72-year-old woman was brought to evaluation with a 5-years history of progressive language and behavioral deterioration. Her family reported early speech errors and behavioral changes, with a marked aggressiveness, ritualistic behaviors and hyperorality. Cognitive evaluation revealed a MMSE of 6/30 mainly due to a relatively fluent afasia. Brain MRI showed asymmetric cerebral atrophy, more prominent in the anterior left temporal lobe. Objective: N/H Methods: N/H Results: N/H Conclusion: We describe two cases of suspected frontotemporal dementia (FTD) syndromes. The left ATL may receive proportionately more input from the lexical and phonological centers subserving word processing. The right ATL may receive more input from right-lateralized emotion processing hubs. Focal atrophy of the left anterior temporal lobe has been associated with the semantic type of primary progressive aphasia evolving to semantic dementia. In contrast, focal atrophy of the right temporal lobe has recently been described as a controversial entity reported as the right temporal variant of FTD.

Perception of Geometrical Figures in Persons with Damaged Temporal Lobes

Perception ◽  
1997 ◽  
Vol 26 (1_suppl) ◽  
pp. 244-244
Author(s):  
R Lukauskiene ◽  
A Bertulis ◽  
I Busauskiene ◽  
B Mickiene
Keyword(s):  
Visual Field ◽  
Temporal Lobe ◽  
Spatial Neglect ◽  
Right Visual Field ◽  
Size Discrimination ◽  
Left Temporal Lobe ◽  
Form Discrimination ◽  
Temporal Lobes ◽  
The Right ◽  
Better Than

Persons with damaged temporal lobes were tested with computerised tests for size and form discrimination developed by A Bulatov and A Bertulis (1994 Perception23 Supplement, 25). 48 persons with damaged right and 54 persons with damaged left temporal lobe were tested. 8 persons showed hemineglect of the right visual field and 10 persons hemineglect of the left visual field. Posner (1987 Neuropsychologia25 135) stated that persons with unilateral spatial neglect had a specific inability to disengage their attention from a given object in order to reallocate it to another object positioned to its left or right. In our studies we determined whether size discrimination abnormalities also occur in the neglected side, opposite to the damaged temporal lobe. We estimated the accuracy with which subjects judged the height of two squares of different colours. Two squares with sizes varying from 0.2 to 3.0 deg were generated on the right and left side of the monitor. Subjects viewed the patterns binocularly at a distance of 1 m and adjusted the size of the square on the left to make its height equal to that on the right. The error of the setting was recorded. Persons with hemineglect of the visual field were unable to concentrate their attention at two figures located on both sides of the monitor so they were unable to make the comparison. Persons with right and left temporal lobe damage without hemineglect of the visual field judged the geometrical figures better than those with hemineglect but worse than controls. Persons with damaged left temporal lobe judged figures less well than persons with damaged right temporal lobe.

A Double Dissociation in the Affective Modulation of Startle in Humans: Effects of Unilateral Temporal Lobectomy

2001 ◽  
Vol 13 (6) ◽  
pp. 721-729 ◽  
Author(s):  
E. Sumie Funayama ◽  
Christian Grillon ◽  
Michael Davis ◽  
Elizabeth A. Phelps
Keyword(s):  
Temporal Lobe ◽  
Visual Information ◽  
Medial Temporal Lobe ◽  
Emotional Processing ◽  
Right Hemisphere ◽  
Temporal Lobectomy ◽  
Opposite Pattern ◽  
Double Dissociation ◽  
Control Subjects ◽  
The Right

In the present study we report a double dissociation between right and left medial temporal lobe damage in the modulation of fear responses to different types of stimuli. We found that right unilateral temporal lobectomy (RTL) patients, in contrast to control subjects and left temporal lobectomy (LTL) patients, failed to show potentiated startle while viewing negative pictures. However, the opposite pattern of impairment was observed during a stimulus that patients had been told signaled the possibility of shock. Control subjects and RTL patients showed potentiated startle while LTL patients failed to show potentiated startle. We hypothesize that the right medial temporal lobe modulates fear responses while viewing emotional pictures, which involves exposure to (emotional) visual information and is consistent with the emotional processing traditionally ascribed to the right hemisphere. In contrast, the left medial temporal lobe modulates fear responses when those responses are the result of a linguistic/cognitive representation acquired through language, which, like other verbally mediated material, generally involves the left hemisphere. Additional evidence from case studies suggests that, within the medial temporal lobe, the amygdala is responsible for this modulation.

Brain activation on fMRI and verbal memory ability: Functional neuroanatomic correlates of CVLT performance

2001 ◽  
Vol 7 (1) ◽  
pp. 55-62 ◽  
Author(s):  
STERLING C. JOHNSON ◽  
ANDREW J. SAYKIN ◽  
LAURA A. FLASHMAN ◽  
THOMAS W. McALLISTER ◽  
MOLLY B. SPARLING
Keyword(s):  
Temporal Lobe ◽  
Verbal Memory ◽  
Medial Temporal Lobe ◽  
Word Processing ◽  
Right Hemisphere ◽  
Verbal Learning ◽  
Clinical Test ◽  
Memory Ability ◽  
The Right ◽  
Novel Words

We have recently reported (Saykin et al., 1999b) selective activation of left medial temporal lobe structures during processing of novel compared to familiar words using functional magnetic resonance imaging (fMRI). The current study describes the relationship between a widely used clinical test of verbal learning, the California Verbal Learning Test (CVLT), and the previously reported fMRI activations. Thirteen right-handed healthy adult participants were studied with whole brain echo-planar fMRI while listening to novel and recently learned (familiar) words intermixed pseudorandomly in an event-related design. These participants were also tested with the CVLT. Scores for CVLT Trial 1 (immediate encoding of novel words) and recognition discriminability (recognition of familiar vs. novel words) were correlated with fMRI signal change during processing of novel versus familiar words using a covariance model implemented in SPM96. For the novel words analysis, voxels in the right anterior hippocampus correlated significantly with Trial 1 (r = .76 at the maxima). For the recognition analysis, a significant cluster of voxels was found in the right dorsolateral prefrontal cortex (r = .88 at the maxima). Our prior results of separable left medial temporal activation to novel and familiar words, together with results of the covariance analyses reported here, suggest that in addition to the left medial temporal lobe (MTL) regions that are engaged during novel and familiar word processing, the right hippocampus and right frontal lobe are also involved, particularly in those participants with better memory ability. This positive relationship between fMRI activation and CVLT performance suggests a role for these right hemisphere regions in successful memory processing of verbal material, perhaps reflecting more efficient encoding and retrieval strategies that facilitate memory. (JINS, 2001, 7, 55–62.)

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