To Determine Outcome of Probiotics in Treatment of Acute Diarrhea in Children

2021 ◽  
Vol 15 (8) ◽  
pp. 1829-1831
Author(s):  
Noshairwan Ali Khan ◽  
Syed Sajid Munir
Keyword(s):  
Acute Diarrhea ◽  
Oral Rehydration Solution ◽  
Saccharomyces Boulardii ◽  
Stool Frequency ◽  
Trial Methodology ◽  
Oral Rehydration ◽  
Group A ◽  
Rehydration Solution ◽  
Randomized Control ◽  
Group B

Aim: To determine outcome of probiotics in treatment of acute diarrhea in children aged 6 months to 5 years as compared to control Setting: Department of Pediatrics, Khyber Teaching Hospital, Peshawar Duration: From 23 May, 2019 to 23 Nov, 2019 Study design: Randomized Control Trial Methodology: 200 children were divided in two equal groups. Group A were given Probiotics (Saccharomyces boulardii) in a dose of 250-500 mg daily in two divided doses for 5 days, in addition to oral rehydration solution 50-100ml and 100-200ml after each loose stool in child aged <2 years and >5 years respectively. Group B were given only oral rehydration solution in same amount as prescribed to Group A. All the children were followed up at day 4. Outcome was assessed in terms of duration of diarrhea and improvement in number of stools per day at the 5th day of presentation. Results: In Group A, 92(92%) patients showed improvement while in Group B, 71(71%) patients showed improvement. Conclusion: Probiotics are found to be significantly more effective in reducing the stool frequency in ac. diarrhea. Keywords: Acute diarrhea, Probiotic, Saccharomyces boulardii (SB)

scholarly journals COMPARISON OF LOW OSMOLAR ORAL REHYDRATION SOLUTION VERSUS STANDARD ORAL REHYDRATION SOLUTION IN CHILDREN WITH ACUTE DIARRHOEA IN RELATION TO UNSCHEDULED INTRAVENOUS FLUID REQUIREMENT

2021 ◽  
Vol 71 (3) ◽  
pp. 1099-1102
Author(s):  
Sidra Tahir ◽  
Rabia Iqbal ◽  
Rabia Najam ◽  
Muneeba Kamran ◽  
Najwa Anwar
Keyword(s):  
Acute Diarrhea ◽  
Oral Rehydration Solution ◽  
Acute Diarrhoea ◽  
P Value ◽  
Chi Square ◽  
Oral Rehydration ◽  
Fluid Requirement ◽  
Group A ◽  
Rehydration Solution ◽  
Group B

Objective: To determine requirement of unscheduled I/V fluid in children treated with low osmolar oral rehydration solution as compare to standard oral rehydration solution. Study Design: Case control study. Place and Duration of Study: Department of Paediatrics, Lahore General Hospital, Lahore, from Sep 2018 to Feb 2019. Methodology: Sample size of 400 patients was calculated using WHO calculator. Patients were recruited through non probability consecutive sampling. Patients were randomly divided into two groups. For each patient detailed history was taken including demographic information. Group A patients (controls) receive standard oral rehydration solution and Group B patients will receive low osmolar oral rehydration solution (Cases). Each group was followed for 6 hours after the treatment. Data analysis was done using SPSS version 24. Chi-square test applied and p-value ≤0.05 found significant. Results: A total of 400 cases were enrolled in the study. There were 220 (55%) male and 180 (45%) female in our study. Mean weight of patients was 9.46 Kg ± 5.9 SD. In group A, 8 patients showed unscheduled fluid requirement while 192 did not showed unscheduled fluid requirement. In group B, 32 patients showed unscheduled fluid requirement while 168 did not showed unscheduled fluid requirement (p=0.000). Conclusions: Incidence of or need of, unscheduled I/V fluid in children treated with low osmolar oral rehydration solution is less as compare to standard oral rehydration solution for management of acute diarrhea with some dehydration. And hence low osmolar oral rehydration solution shows better acceptance in management of acute diarrhea.

Clinical Trial of Glucose-Oral Rehydration Solution (ORS), Rice Dextrin-ORS, and Rice Flour-ORS for the Management of Children With Acute Diarrhea and Mild or Moderate Dehydration

PEDIATRICS ◽  
1995 ◽  
Vol 95 (2) ◽  
pp. 191-197
Author(s):  
Susana Molina ◽  
Carolina Vettorazzi ◽  
Janet M. Peerson ◽  
Noel W. Solomons ◽  
Kenneth H. Brown
Keyword(s):  
Clinical Trial ◽  
Treatment Group ◽  
Acute Diarrhea ◽  
Oral Rehydration Solution ◽  
Rice Flour ◽  
Watery Diarrhea ◽  
Hydration Status ◽  
Oral Rehydration ◽  
Acute Watery Diarrhea ◽  
Rehydration Solution

Objective. To assess the effects of glucose (G)-oral rehydration solution (ORS), rice dextrin (RD)-ORS, and rice flour (RF)-ORS on fluid intake, rapidity of rehydration, and stool output of children with acute diarrhea and mild or moderate dehydration. Methods. The study was a randomized, double-masked clinical trial. One hundred forty-six male infants, ages 3 to 36 months, were randomly assigned to one of three treatment groups. Clinical evaluations and fluid balances were conducted every 2 to 4 hours for 48 hours. Principal outcome variables were ORS consumption, recovery of hydration status, and fecal output. Results. The groups were similar at admission with regard to age, nutritional status, history of the current episode, and clinical status. There were no differences in ORS consumption by treatment group during any period of study. During the first 6-hour period, patients in group RF had less stool output (16 ± 14 g/kg/body weight) than those in group G (22 ± 20 g/kg) or RD (21 ± 19 g/kg; P &lt; .05). After 12 hours of hospitalization, there were no differences by treatment group. Recovery of hydration status, changes in serum sodium and potassium, and duration of diarrhea in the hospital were similar in all three groups. Conclusion. There was a 24% to 27% reduction in stool output during the first 6 hours of treatment among children who received RF-ORS compared with those who received G-ORS or RD-ORS, but this effect did not persist after the first 12 hours of therapy. Because this difference was of small magnitude and limited duration, it has minor clinical importance. Thus, we conclude that the three solutions had similar efficacy for children with acute, watery diarrhea and mild or moderate dehydration.

A comparison of rice-based oral rehydration solution and “early feeding” for the treatment of acute diarrhea in infants

1990 ◽  
Vol 116 (6) ◽  
pp. 868-875 ◽  
Author(s):  
Mathuram Santosham ◽  
Ibrahim M. Fayad ◽  
Mohamed Hashem ◽  
Julius G. Goepp ◽  
Mamdouh Refaf ◽  
...  
Keyword(s):  
Acute Diarrhea ◽  
Oral Rehydration Solution ◽  
Early Feeding ◽  
Oral Rehydration ◽  
Rehydration Solution

A Packaged Rice-Based Oral Rehydration Solution for Acute Diarrhea

1995 ◽  
Vol 20 (4) ◽  
pp. 408-416 ◽  
Author(s):  
Denis V. Barclay ◽  
Joaquina Gil-Ramos ◽  
José O. Mora ◽  
Henri Dirren
Keyword(s):  
Acute Diarrhea ◽  
Oral Rehydration Solution ◽  
Oral Rehydration ◽  
Rehydration Solution

Oral Rehydration Solution for Acute Diarrhea Prevents Subsequent Unscheduled Follow-up Visits

PEDIATRICS ◽  
1999 ◽  
Vol 104 (3) ◽  
pp. e29-e29 ◽  
Author(s):  
Christopher Duggan ◽  
Jack Lasche ◽  
Martha McCarty ◽  
Kathleen Mitchell ◽  
Robert Dershewitz ◽  
...  
Keyword(s):  
Acute Diarrhea ◽  
Oral Rehydration Solution ◽  
Oral Rehydration ◽  
Rehydration Solution

Efficacy of zinc-fortified oral rehydration solution in 6- to 35-month-old children with acute diarrhea

2002 ◽  
Vol 141 (5) ◽  
pp. 677-682 ◽  
Author(s):  
Rajiv Bahl ◽  
Nita Bhandari ◽  
Manju Saksena ◽  
Tor Strand ◽  
Geeta T. Kumar ◽  
...  
Keyword(s):  
Acute Diarrhea ◽  
Oral Rehydration Solution ◽  
Oral Rehydration ◽  
Rehydration Solution

Role of a Soy-Based Lactose-Free Formula in the Outpatient Management of Diarrhea

PEDIATRICS ◽  
1991 ◽  
Vol 87 (5) ◽  
pp. 619-622
Author(s):  
Mathuram Santosham ◽  
Julius Goepp ◽  
Barbara Burns ◽  
Raymond Reid ◽  
R. Bradley Sack ◽  
...  
Keyword(s):  
Acute Diarrhea ◽  
Oral Rehydration Solution ◽  
Caloric Intake ◽  
The United States ◽  
Control Group ◽  
Early Feeding ◽  
Oral Rehydration ◽  
Feeding Group ◽  
Rehydration Solution

The introduction of a soy-based, lactose-free formula during the acute phase of diarrheal illness in infants has been shown to reduce stool output and duration of diarrhea in hospitalized patients. In the United States, most infants with acute diarrhea are treated as outpatients. In the present study, infants with diarrhea who were treated as outpatients were randomly assigned to receive either a soy-based, lactose-free formula alternating with oral rehydration solution from the beginning of therapy ("early feeding") or oral rehydration solution alone for the first 24 hours of therapy, followed by a soy-based, lactose-free formula alternating with oral rehydration solution (control group). Twenty-nine infants were randomly assigned to the early-feeding group and 27 to the control group. Twenty-one (72%) of 29 in the early-feeding group resolved their diarrhea at the end of 48 hours of therapy compared with 12 (44%) of 27 in the group fed oral rehydration solution only (P = .02). It is concluded that the introduction of a soy-based, lactose-free formula from the beginning of therapy for acute diarrhea in children treated as outpatients is safe and may shorten duration of diarrhea while maintaining adequate caloric intake.

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