Unusual Presentation of Calcinosis Cutis: Venous Calcification Following intravenous Calcium Gluconate Administration in a Preterm Baby

An adult male cat presented to the Ontario Veterinary College after having a seizure at the humane society. The cat was diagnosed with primary hypoparathyroidism and was treated with calcium and vitamin D3 supplementation. Calcium supplementation included subcutaneous (SC) administration of diluted calcium gluconate according to protocols described in recent literature. Seven days after SC calcium administration, firm SC masses developed in the intrascapular area where the injections were given and in the dependent axillary area. These areas became raised, formed crusts, necrosed, and left scars. Although not histopathologically confirmed, the author postulates that this was a direct reaction to SC calcium gluconate administration.

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Neonate with calcinosis cutis following extravasation of calcium gluconate

Journal of Orthopaedic Science ◽

10.1007/s00776-007-1217-z ◽

2008 ◽

Vol 13 (3) ◽

pp. 269-272 ◽

Cited By ~ 12

Author(s):

Motoki Sonohata ◽

Takayuki Akiyama ◽

Ichiro Fujita ◽

Akihiko Asami ◽

Masaaki Mawatari ◽

...

Keyword(s):

Calcium Gluconate ◽

Calcinosis Cutis

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Severe calcinosis cutis associated with treatment of hypoparathyroidism in a dog

Journal of the American Animal Hospital Association ◽

10.5326/15473317-37-4-364 ◽

2001 ◽

Vol 37 (4) ◽

pp. 364-369 ◽

Cited By ~ 19

Author(s):

M Schaer ◽

PE Ginn ◽

LE Fox ◽

J Leon ◽

FM Ramirez

Keyword(s):

Calcium Gluconate ◽

Skin Necrosis ◽

Calcinosis Cutis ◽

Abdominal Skin ◽

Medical Evaluation

A 6-month-old, female border collie was referred for evaluation of hypocalcemia, hyperphosphatemia, fever, and painful ventral abdominal skin. She had recently been treated intravenously and subcutaneously (SC) with a diluted 10% calcium gluconate solution. The medical evaluation supported the diagnosis of primary hypoparathyroidism, but the subsequent hospital course was complicated by severe calcinosis cutis, which caused extensive skin necrosis and marked debilitation. This patient illustrates that administration of a calcium gluconate solution SC can be associated with extensive morbidity when administered to hyperphosphatemic patients.

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Failure of Intravenous Calcium Gluconate for Hydrofluoric Acid Burns

Annals of Emergency Medicine ◽

10.1067/mem.2000.110019 ◽

2000 ◽

Vol 36 (4) ◽

pp. 0398-0399 ◽

Cited By ~ 1

Author(s):

Geoffrey K. Isbister

Keyword(s):

Calcium Gluconate ◽

Hydrofluoric Acid ◽

Intravenous Calcium

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Change of ionized calcium level in the first 48 hours of age of preterm newborns administered with two different dosages of intravenous calcium gluconate

Paediatrica Indonesiana ◽

10.14238/pi50.2.2010.96-100 ◽

2010 ◽

Vol 50 (2) ◽

pp. 96

Author(s):

Anton Wibowo ◽

Dedi Rachmadi Sambas ◽

Abdurachman Sukadi

Keyword(s):

Calcium Gluconate ◽

Repeated Measures ◽

Calcium Level ◽

Ionized Calcium ◽

Randomized Controlled ◽

Sick Newborn ◽

Repeated Measures Analysis ◽

Blood Specimens ◽

Preterm Newborns ◽

Intravenous Calcium

Background Physiologically, serum calcium level declines till nadirin a few hours after birth and continues for 24-48 hours. No studyperformed in order to know the alteration ofionized calcium levelof newborn in the first 48 hours of age. The sick newborn musthave parenteral calcium to avoid hypocalcemia but there is stillno agreement about the dose.Objective To determine the change of ionized calcium level inthe first 48 hours of age of preterm newborns administered withperipheral drip intravenous 10% calcium gluconate of2.6 mIJkg/day and 5 mUkg/day.Methods An open labeled randomized controlled clinical trialwas performed between April and June 2009. After birth bloodspecimen of preterms was obtained for leukocyte, platelet,magnesium, phosphorous, and ionized calcium measurements.Subjects received either 2.6 mL/kg/day or 5 mL/kg/day ofperipheral drip intravenous 10% calcium gluconate immediatelyafter birth for 48 hours. Blood specimens was obtained again on48 hours of age for ionized calcium. This study were analyzedusing repeated measures analysis of varians.Results Forty preterm newborns (20 subjects each group) wereanalyzed. There was no statistical difference between bothdoses (Factor-A) on 48 hours ionized calcium level (P=0.33)and ionized calcium level alteration based on time (Factor-B)(P=0.20). Interaction between both factors was significantlydifferent (P=0.035).Conclusion Ionized calcium level in 48 hours of age of pretermnewborn administered with both doses of 10% calcium gluconate isnot different but dose of2.6 mL/kg/day yields physiologic alterationof ionized calcium level compared with 5 mL/kg/day.

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