scholarly journals Validation of MALDI-TOF MS devices in reanalysis of unidentified pathogenic bacteria detected in blood cultures

2020 ◽  
Vol 66 (2) ◽  
pp. 103-112
Author(s):  
Minako Imai ◽  
Yukio Kimura ◽  
Daiki Tanno ◽  
Kyoichi Saito ◽  
Mutsuko Honda ◽  
...  
Keyword(s):  
Pathogenic Bacteria ◽  
Blood Cultures ◽  
Maldi Tof Ms ◽  
Maldi Tof ◽  
Tof Ms

Identification of pathogenic bacteria in human blood using IgG-modified Fe3O4 magnetic beads as a sorbent and MALDI-TOF MS for profiling

2018 ◽  
Vol 185 (12) ◽  
Author(s):  
Jia Yi ◽  
Qin Qin ◽  
Yan Wang ◽  
Rutan Zhang ◽  
Hongyan Bi ◽  
...  
Keyword(s):  
Human Blood ◽  
Pathogenic Bacteria ◽  
Magnetic Beads ◽  
Maldi Tof Ms ◽  
Maldi Tof ◽  
Tof Ms

scholarly journals Effect of Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry (MALDI-TOF MS) Alone versus MALDI-TOF MS Combined with Real-Time Antimicrobial Stewardship Interventions on Time to Optimal Antimicrobial Therapy in Patients with Positive Blood Cultures

2017 ◽  
Vol 55 (5) ◽  
pp. 1437-1445 ◽  
Author(s):  
Maya Beganovic ◽  
Michael Costello ◽  
Sarah M. Wieczorkiewicz
Keyword(s):  
Real Time ◽  
Laser Desorption ◽  
Blood Cultures ◽  
Laser Desorption Ionization ◽  
Ionization Time ◽  
Maldi Tof Ms ◽  
Maldi Tof ◽  
Flight Mass Spectrometry ◽  
Tof Ms ◽  
Matrix Assisted Laser

ABSTRACT Matrix-assisted laser desorption ionization–time of flight mass spectrometry (MALDI-TOF MS) decreases the time to organism identification and improves clinical and financial outcomes. The purpose of this study was to evaluate the impact of MALDI-TOF MS alone versus MALDI-TOF MS combined with real-time, pharmacist-driven, antimicrobial stewardship (AMS) intervention on patient outcomes. This single-center, pre-post, quasiexperimental study evaluated hospitalized patients with positive blood cultures identified via MALDI-TOF MS combined with prospective AMS intervention compared to a control cohort with MALDI-TOF MS identification without AMS intervention. AMS intervention included: real-time MALDI-TOF MS pharmacist notification and prospective AMS provider feedback. The primary outcome was the time to optimal therapy (TTOT). A total of 252 blood cultures, 126 in each group, were included in the final analysis. MALDI-TOF MS plus AMS intervention significantly reduced the overall TTOT (75.17 versus 43.06 h; P < 0.001), the Gram-positive contaminant TTOT (48.21 versus 11.75 h; P < 0.001), the Gram-negative infection (GNI) TTOT (71.83 versus 35.98 h; P < 0.001), and the overall hospital length of stay (LOS; 15.03 versus 9.02 days; P = 0.021). The TTOT for Gram-positive infection (GPI) was improved (64.04 versus 41.61 h; P = 0.082). For GPI, the hospital LOS (14.64 versus 10.31 days; P = 0.002) and length of antimicrobial therapy 24.30 versus 18.97 days; P = 0.018) were reduced. For GNI, the time to microbiologic clearance (51.13 versus 34.51 h; P < 0.001), the hospital LOS (15.40 versus 7.90 days; P = 0.027), and the intensive care unit LOS (5.55 versus 1.19 days; P = 0.035) were reduced. To achieve optimal outcomes, rapid identification with MALDI-TOF MS combined with real-time AMS intervention is more impactful than MALDI-TOF MS alone.

MALDI-TOF MS-Based Identification of Bacteria and a Survey of Fresh Vegetables with Pathogenic Bacteria in Beijing, China

2020 ◽  
pp. 100746
Author(s):  
Xiaomin Xu ◽  
Guangyang Liu ◽  
Xiaodong Huang ◽  
Lingyun Li ◽  
Huan Lin ◽  
...  
Keyword(s):  
Pathogenic Bacteria ◽  
Maldi Tof Ms ◽  
Maldi Tof ◽  
Fresh Vegetables ◽  
Identification Of Bacteria ◽  
Beijing China ◽  
Tof Ms

scholarly journals Impact of MALDI-TOF-MS-based identification directly from positive blood cultures on patient management: a controlled clinical trial

2017 ◽  
Vol 23 (2) ◽  
pp. 78-85 ◽  
Author(s):  
M. Osthoff ◽  
N. Gürtler ◽  
S. Bassetti ◽  
G. Balestra ◽  
S. Marsch ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Patient Management ◽  
Blood Cultures ◽  
Controlled Clinical Trial ◽  
Maldi Tof Ms ◽  
Maldi Tof ◽  
Tof Ms

Identification of Human Pathogenic Bacteria in Plant Roots by Using MALDI-TOF MS Methodology

2016 ◽  
pp. 3-12
Author(s):  
Encarna Velázquez ◽  
Esther Menéndez ◽  
Fernando Sánchez Juanes ◽  
Noemí Valencia Daza ◽  
Juan Pérez Yépez ◽  
...  
Keyword(s):  
Pathogenic Bacteria ◽  
Plant Roots ◽  
Maldi Tof Ms ◽  
Human Pathogenic Bacteria ◽  
Maldi Tof ◽  
Tof Ms

Principal component analysis of MALDI-TOF MS of whole-cell foodborne pathogenic bacteria

2020 ◽  
Vol 592 ◽  
pp. 113582 ◽  
Author(s):  
Wenjing Yan ◽  
Jing Qian ◽  
Yongjie Ge ◽  
Keping Ye ◽  
Cunshan Zhou ◽  
...  
Keyword(s):  
Principal Component Analysis ◽  
Pathogenic Bacteria ◽  
Principal Component ◽  
Component Analysis ◽  
Whole Cell ◽  
Maldi Tof Ms ◽  
Maldi Tof ◽  
Foodborne Pathogenic Bacteria ◽  
Tof Ms
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