THE SCOPE OF METAL COMPLEXES IN DRUG DESIGN - A REVIEW

INDIAN DRUGS ◽  
2012 ◽  
Vol 49 (11) ◽  
pp. 5-12
Author(s):  
S. R. Pattan ◽  
◽  
S. B Pawar ◽  
S. S. Vetal ◽  
U. D. Gharate ◽  
...  
Keyword(s):  
Inorganic Chemistry ◽  
Metal Complexes ◽  
Anticancer Agents ◽  
Scientific Inquiry ◽  
Metal Species ◽  
Biological Media ◽  
Metal Compounds ◽  
Medicinal Uses ◽  
Diagnostic Agents ◽  
Medicinal Inorganic Chemistry

A significantly rising interest in the design of metal compounds as drugs and diagnostic agents is currently observed in the area of scientific inquiry, appropriately termed medicinal inorganic chemistry. Investigations in this area focus mostly on the speciation of metal species in biological media based on possible interactions of these metal ions with diverse biomolecules, in an effort to contribute to future development of new therapeutics or diagnostic agents. Metallopharmaceuticals used as anticancer agents, metal-mediated antibiotics, antibacterials, antivirals, antiparasitics, antiarthritics, antidiabetics and radio-sensitizing agents appear in therapeutic medicinal inorganic chemistry. The medicinal uses and applications of metals and metal complexes are of increasing clinical and commercial importance.

Metal complexes of maltol and close analogues in medicinal inorganic chemistry

2006 ◽  
Vol 35 (6) ◽  
pp. 545 ◽  
Author(s):  
Katherine H. Thompson ◽  
Cheri A. Barta ◽  
Chris Orvig
Keyword(s):  
Inorganic Chemistry ◽  
Metal Complexes ◽  
Medicinal Inorganic Chemistry

Metal Complexes of Maltol and Close Analogues in Medicinal Inorganic Chemistry

ChemInform ◽  
2006 ◽  
Vol 37 (37) ◽  
Author(s):  
Katherine H. Thompson ◽  
Cheri A. Barta ◽  
Chris Orvig
Keyword(s):  
Inorganic Chemistry ◽  
Metal Complexes ◽  
Medicinal Inorganic Chemistry

scholarly journals Pre-/post-functionalization in dipyrrin metal complexes – antitumor and antibacterial activity of their glycosylated derivatives

2018 ◽  
Vol 47 (35) ◽  
pp. 12373-12384 ◽  
Author(s):  
Claudia S. Gutsche ◽  
Susanna Gräfe ◽  
Burkhard Gitter ◽  
Keith J. Flanagan ◽  
Mathias O. Senge ◽  
...  
Keyword(s):  
Inorganic Chemistry ◽  
Antibacterial Activity ◽  
Metal Complexes ◽  
Medicinal Inorganic Chemistry ◽  
Post Functionalization

A post-functionalization route to tris(dipyrrinato) metal complexes is presented giving access to a range of new complexes relevant in the context of medicinal inorganic chemistry.

Novel Chemotherapeutic Agents - The Contribution of Scorpionates

2020 ◽  
Vol 26 (41) ◽  
pp. 7452-7475 ◽  
Author(s):  
Marta A. Andrade ◽  
Luísa M.D.R.S. Martins
Keyword(s):  
Transition Metal ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Anticancer Agents ◽  
Medicinal Chemistry ◽  
Bioinorganic Chemistry ◽  
Chemotherapeutic Agents ◽  
Great Role ◽  
Anticancer Properties ◽  
Scorpionate Ligands

: The development of safe and effective chemotherapeutic agents is one of the uppermost priorities and challenges of medicinal chemistry and new transition metal complexes are being continuously designed and tested as anticancer agents. Scorpionate ligands have played a great role in coordination chemistry, since their discovery by Trofimenko in the late 1960s, with significant contributions in the fields of catalysis and bioinorganic chemistry. Scorpionate metal complexes have also shown interesting anticancer properties, and herein, the most recent (last decade) and relevant scorpionate complexes reported for application in medicinal chemistry as chemotherapeutic agents are reviewed. The current progress on the anticancer properties of transition metal complexes bearing homo- or hetero- scorpionate ligands, derived from bis- or tris-(pyrazol-1-yl)-borate or -methane moieties is highlighted.

scholarly journals Frustration across the periodic table: heterolytic cleavage of dihydrogen by metal complexes

2017 ◽  
Vol 375 (2101) ◽  
pp. 20170002 ◽  
Author(s):  
R. Morris Bullock ◽  
Geoffrey M. Chambers
Keyword(s):  
Transition Metal ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Molecular Complexes ◽  
Main Group ◽  
Lewis Base ◽  
Metal Compounds ◽  
Metal Catalysis ◽  
Heterolytic Cleavage ◽  
Lewis Pairs

This perspective examines frustrated Lewis pairs (FLPs) in the context of heterolytic cleavage of H 2 by transition metal complexes, with an emphasis on molecular complexes bearing an intramolecular Lewis base. FLPs have traditionally been associated with main group compounds, yet many reactions of transition metal complexes support a broader classification of FLPs that includes certain types of transition metal complexes with reactivity resembling main group-based FLPs. This article surveys transition metal complexes that heterolytically cleave H 2 , which vary in the degree that the Lewis pairs within these systems interact. Many of the examples include complexes bearing a pendant amine functioning as the base with the metal functioning as the hydride acceptor. Consideration of transition metal compounds in the context of FLPs can inspire new innovations and improvements in transition metal catalysis. This article is part of the themed issue ‘Frustrated Lewis pair chemistry’.

Carbohydrate-Metal Complexes and their Potential as Anticancer Agents

2008 ◽  
Vol 15 (25) ◽  
pp. 2574-2591 ◽  
Author(s):  
Christian Hartinger ◽  
Alexey Nazarov ◽  
Shaheen Ashraf ◽  
Paul Dyson ◽  
Bernhard Keppler
Keyword(s):  
Metal Complexes ◽  
Anticancer Agents
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