COLOCASIA ESCULENTA STARCH: NOVEL ALTERNATIVE DISINTEGRANT FOR PHARMACEUTICAL APPLICATION

Oral drug delivery system has always been the most prevalent route of administration and continuous efforts are made to improve the drug delivery by this route. Tablets are one of the most extensively used dosage forms and various excipients have been developed for their formulation. The purpose of the current research work was to isolate and study the physicochemical properties of the Colocasia esculenta starch and further compare its disintegration ability with maize starch. Starch was isolated from C. esculenta corms by aqueous extraction method and possesses characteristics that are typical of starches. It was further evaluated for the presence of other foreign matter and phytoconstituents. Results showed that the isolated sample was free from foreign organic matter and the total ash value was found to be 0.4%. Tablets were prepared by the wet granulation method by varying concentrations in the range of 2.5 to 10% w/w for both the starches. Pre and post-compression parameters were studied and were found to be within the pharmacopoeial limits. Disintegration tests showed that disintegration time decreases with increasing concentration of both the starches. At 10% w/w concentration, disintegration time was found to be lowest, hence it was selected as an optimized formulation Stability studies were performed on F4 batch and it was found to be stable. The determination of disintegration efficiency indicates that C. esculenta starch exhibits disintegrating potential.

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Fat-Soluble Vitamins Release Based on Clinoptilolite Zeolite as an Oral Drug Delivery System

Letters in Drug Design & Discovery ◽

10.2174/157018012799079833 ◽

2012 ◽

Vol 9 (2) ◽

pp. 213-217 ◽

Cited By ~ 7

Author(s):

Mehdi Rahimi ◽

Hamid Mobedi ◽

Aliasghar Behnamghader ◽

Alireza Nateghi Baygi ◽

Houri Mivehchi ◽

...

Keyword(s):

Drug Delivery ◽

Drug Delivery System ◽

Delivery System ◽

Oral Drug Delivery ◽

Oral Drug ◽

Oral Drug Delivery System ◽

Clinoptilolite Zeolite ◽

Fat Soluble Vitamins

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Fenofibrate Nanocrystal Composite Microparticles for Intestine-Specific Oral Drug Delivery System

Pharmaceuticals ◽

10.3390/ph12030109 ◽

2019 ◽

Vol 12 (3) ◽

pp. 109 ◽

Cited By ~ 2

Author(s):

Bhavesh D. Kevadiya ◽

Liang Chen ◽

Lu Zhang ◽

Midhun B. Thomas ◽

Rajesh N. Davé

Keyword(s):

Drug Delivery ◽

Oral Drug Delivery ◽

Imaging System ◽

Oral Drug ◽

Burst Release ◽

Particle Engineering ◽

Oral Drug Delivery System ◽

Innovative Idea ◽

Fast Dissolution ◽

A Site

Hydrophobic drug nanocrystals (NCs) manufactured by particle engineering have been extensively investigated for enhanced oral bioavailability and therapeutic effectiveness. However, there are significant drawbacks, including fast dissolution of the nanocrystals in the gastric environment, leading to physicochemical instability. To solves this issue, we developed an innovative technique that involves the encapsulation of nanocrystals in composite spherical microparticles (NCSMs). Fenofibrate (FNB) NCs (FNB-NCs) manufactured by a wet stirred media milling (WSMM) technique and an ionotropic crosslinking method were used for FNB-NC encapsulation within gastroresistant NCSMs. Various solid-state methods were used for characterizing NCSMs. The pH-sensitive NCSMs showed a site-specific release pattern at alkaline pH and nearly 0% release at low pH (gastric environment). This phenomenon was confirmed by a real-time in situ UV-imaging system known as the surface dissolution imager (SDI), which was used to monitor drug release events by measuring the color intensity and concentration gradient formation. All these results proved that our NCSM approach is an innovative idea in oral drug delivery systems, as it resolves significant challenges in the intestine-specific release of hydrophobic drugs while avoiding fast dissolution or burst release.

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