scholarly journals Ondansetron HCl Microemulsions for Transdermal Delivery: Formulation and In Vitro Skin Permeation

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Jadupati Malakar ◽  
Amit Kumar Nayak ◽  
Aalok Basu
Keyword(s):  
Transdermal Delivery ◽  
Isopropyl Alcohol ◽  
Skin Permeation ◽  
Tween 80 ◽  
Oral Route ◽  
Isopropyl Myristate ◽  
Surfactant Phase ◽  
In Vitro Skin Permeation ◽  
Pass Metabolism

Ondansetron HCl delivery through oral route suffers due to its low bioavailability due to first-pass metabolism. Therefore, the microemulsion-based transdermal delivery may be a better substitute for it. The pseudoternary phase diagrams were constructed to determine compositions of microemulsions, and ondansetron HCl microemulsions for transdermal delivery were developed using isopropyl myristate or oleic acid as the oil phase, Tween 80 as the surfactant, and isopropyl alcohol as the cosurfactant evaluated for in vitro skin permeation through excised porcine skin. The in vitro skin permeation from these formulated microemulsions was sustained over 24 hours. The microemulsion F-8 (contained 10% of isopropyl myristate as oil phase, 8% of aqueous phase, and 82% of surfactant phase containing Tween 80 and isopropyl alcohol, 3 : 1) showed the highest permeation flux of 0.284±0.003 μg/cm2/hour. All these microemulsions followed the Korsmeyer-Peppas model (R2=0.971  to  0.998) with non-Fickian, “anomalous” mechanism over a period of 24 hours.

scholarly journals Development and Evaluation of Microemulsions for Transdermal Delivery of Insulin

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Jadupati Malakar ◽  
Suma Oomen Sen ◽  
Amit Kumar Nayak ◽  
Kalyan Kumar Sen
Keyword(s):  
Oleic Acid ◽  
Transdermal Delivery ◽  
Isopropyl Alcohol ◽  
Mouse Skin ◽  
Tween 80 ◽  
Isopropyl Myristate ◽  
Permeation Flux ◽  
Goat Skin ◽  
Surfactant Phase

Insulin-loaded microemulsions for transdermal delivery were developed using isopropyl myristate or oleic acid as the oil phase, Tween 80 as the surfactant, and isopropyl alcohol as the cosurfactant. The pseudoternary phase diagrams were constructed to determine the composition of microemulsions. The insulin permeation flux of microemulsions containing oleic acid as oil phase through excised mouse skin and goat skin was comparatively greater than that of microemulsions containing isopropyl myristate as oil phase. The insulin-loaded microemulsion containing 10% oleic acid, 38% aqueous phase, and 50% surfactant phase with 2% dimethyl sulfoxide (DMSO) as permeation enhancer showed maximum permeation flux (4.93 ± 0.12 μg/cm2/hour) through goat skin. The in vitro insulin permeation from these microemulsions was found to follow the Korsmeyer-Peppas model (R2=0.923 to 0.973) over a period of 24 hours with non-Fickian, “anomalous” mechanism. Together these preliminary data indicate the promise of microemulsions for transdermal delivery of insulin.

Transdermal Delivery of Metoprolol II: In-Vitro Skin Permeation and Bioavailability in Hairless Rats

1995 ◽  
Vol 84 (2) ◽  
pp. 158-160 ◽  
Author(s):  
Tapash K. Ghosh ◽  
Joseph Adir ◽  
Si‐Ling Xiang ◽  
Samuel Onyilofur
Keyword(s):  
Transdermal Delivery ◽  
Skin Permeation ◽  
In Vitro Skin Permeation

scholarly journals Design, development and evaluation of novel nanoemulsion formulations for transdermal potential of celecoxib

2007 ◽  
Vol 57 (3) ◽  
pp. 315-332 ◽  
Author(s):  
Sanjula Baboota ◽  
Faiyaz Shakeel ◽  
Alka Ahuja ◽  
Javed Ali ◽  
Sheikh Shafiq
Keyword(s):  
Transdermal Delivery ◽  
Permeability Coefficient ◽  
Skin Permeation ◽  
Tween 80 ◽  
Surfactant Mixture ◽  
Design Development ◽  
Paw Edema ◽  
Steady State Flux ◽  
Nanoemulsion Gel

Design, development and evaluation of novel nanoemulsion formulations for transdermal potential of celecoxibThe aim of the present study was to investigate the potential of nanoemulsion formulations for transdermal delivery of celecoxib (CXB). Thein vitroskin permeation profile of optimized formulations was compared with CXB gel and nanoemulsion gel. Significant increase in the steady state flux (Jss), permeability coefficient (Kp) and enhancement ratio (Er) was observed in nanoemulsion formulations T1 and T2 (p< 0.05). The highest value of these permeability parameters was obtained in formulation T2, which consisted of 2% (m/m) of CXB, 10% (m/m) of oil phase (Sefsol 218 and Triacetin), 50% (m/m) of surfactant mixture (Tween-80 and Transcutol-P) and 40% (m/m) water. The anti-inflammatory effects of formulation T2 showed a significant increase (p< 0.05) in inhibition after 24 h compared to CXB gel and nanoemulsion gel on carrageenan-induced paw edema in rats. These results suggested that nanoemulsions are potential vehicles for improved transdermal delivery of CXB.

scholarly journals Elastic liposomes mediated transdermal delivery of verapamil hydrochloride

2018 ◽  
Vol 8 (6) ◽  
pp. 16-21
Author(s):  
NEHA JAIN ◽  
Ameeta Argal ◽  
Girendra Gautam
Keyword(s):  
Transdermal Delivery ◽  
Skin Permeation ◽  
Entrapment Efficiency ◽  
Sprague Dawley ◽  
Rat Skin ◽  
Verapamil Hydrochloride ◽  
In Vitro Skin Permeation ◽  
Permeation Studies ◽  
Elastic Vesicles

The aim of present investigation was to formulate and characterize elastic liposomes as a delivery system for transdermal delivery of Verapamil hydrochloride, a drug having low oral bioavailability (approx 20%), short biological half-life and extensive first pass metabolism.Verapamil hydrochloride loaded elastic vesicles were prepared by a slightly modified extrusion method using soya phosphatidylcholine and span 80(edge activator). Prepared elastic vesicles were characterized for various parameters such as vesicle shape, vesicle size and size distribution, entrapment efficiency, elasticity measurements, stability studies and in vitro skin permeation studies through excised rat skin (Sprague Dawley) using a locally fabricated Franz diffusion cell. The entrapment efficiency of elastic vesicles was found to be 59.3±3.6%. In vitro skin permeation of verapamil hydrochloride through excised rat skin (Sprague Dawley) revealed that elastic vesicles led to an enhanced transdermal flux (50.2±4.52 mg/cm2/h) of verapamil hydrochloride as compared to liposomes (11.6±2.12mg/cm2/h). Decreased lag time (0.9 h) was also observed in case of elastic liposomes. Our results indicate the feasibility of elastic liposomes for transdermal delivery of verapamil hydrochloride for improved skin permeation. Keywords: Transdermal delivery, Elastic liposomes, Verapamil hydrochloride.  

scholarly journals Physical Characterizations and In Vitro Skin Permeation of Elastic Liposomes for Transdermal Delivery of Polygonum aviculare L. Extract

Polymer Korea ◽  
2014 ◽  
Vol 38 (6) ◽  
pp. 694-701 ◽  
Author(s):  
Saet Byeol Han ◽  
Soon Sik Kwon ◽  
Yoo Min Jeong ◽  
Bong Ju Kong ◽  
Eun Ryeong Yu ◽  
...  
Keyword(s):  
Transdermal Delivery ◽  
Skin Permeation ◽  
Polygonum Aviculare ◽  
In Vitro Skin Permeation

Transdermal Delivery of Quercetin Using Elastic Liposomes: Preparation, Characterization and In Vitro Skin Permeation Study

Polymer Korea ◽  
2012 ◽  
Vol 36 (6) ◽  
pp. 705-711 ◽  
Author(s):  
Soo Nam Park ◽  
Myoung Sun Lim ◽  
Min A Park ◽  
Soon Sik Kwon ◽  
Seat Byeol Han
Keyword(s):  
Transdermal Delivery ◽  
Skin Permeation ◽  
Permeation Study ◽  
In Vitro Skin Permeation
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