Transdermal Delivery of Quercetin Using Elastic Liposomes: Preparation, Characterization and In Vitro Skin Permeation Study

Polymer Korea ◽  
2012 ◽  
Vol 36 (6) ◽  
pp. 705-711 ◽  
Author(s):  
Soo Nam Park ◽  
Myoung Sun Lim ◽  
Min A Park ◽  
Soon Sik Kwon ◽  
Seat Byeol Han
Keyword(s):  
Transdermal Delivery ◽  
Skin Permeation ◽  
Permeation Study ◽  
In Vitro Skin Permeation

Transdermal Delivery of Metoprolol II: In-Vitro Skin Permeation and Bioavailability in Hairless Rats

1995 ◽  
Vol 84 (2) ◽  
pp. 158-160 ◽  
Author(s):  
Tapash K. Ghosh ◽  
Joseph Adir ◽  
Si‐Ling Xiang ◽  
Samuel Onyilofur
Keyword(s):  
Transdermal Delivery ◽  
Skin Permeation ◽  
In Vitro Skin Permeation

scholarly journals Ondansetron HCl Microemulsions for Transdermal Delivery: Formulation and In Vitro Skin Permeation

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Jadupati Malakar ◽  
Amit Kumar Nayak ◽  
Aalok Basu
Keyword(s):  
Transdermal Delivery ◽  
Isopropyl Alcohol ◽  
Skin Permeation ◽  
Tween 80 ◽  
Oral Route ◽  
Isopropyl Myristate ◽  
Surfactant Phase ◽  
In Vitro Skin Permeation ◽  
Pass Metabolism

Ondansetron HCl delivery through oral route suffers due to its low bioavailability due to first-pass metabolism. Therefore, the microemulsion-based transdermal delivery may be a better substitute for it. The pseudoternary phase diagrams were constructed to determine compositions of microemulsions, and ondansetron HCl microemulsions for transdermal delivery were developed using isopropyl myristate or oleic acid as the oil phase, Tween 80 as the surfactant, and isopropyl alcohol as the cosurfactant evaluated for in vitro skin permeation through excised porcine skin. The in vitro skin permeation from these formulated microemulsions was sustained over 24 hours. The microemulsion F-8 (contained 10% of isopropyl myristate as oil phase, 8% of aqueous phase, and 82% of surfactant phase containing Tween 80 and isopropyl alcohol, 3 : 1) showed the highest permeation flux of 0.284±0.003 μg/cm2/hour. All these microemulsions followed the Korsmeyer-Peppas model (R2=0.971  to  0.998) with non-Fickian, “anomalous” mechanism over a period of 24 hours.

scholarly journals Usefulness of Rat Skin as a Substitute for Human Skin in the in Vitro Skin Permeation Study

2011 ◽  
Vol 60 (4) ◽  
pp. 373-384 ◽  
Author(s):  
Hiroyuki TAKEUCHI ◽  
Yoko MANO ◽  
Shuichi TERASAKA ◽  
Takanobu SAKURAI ◽  
Atsushi FURUYA ◽  
...  
Keyword(s):  
Human Skin ◽  
Skin Permeation ◽  
Rat Skin ◽  
Permeation Study ◽  
In Vitro Skin Permeation

scholarly journals Elastic liposomes mediated transdermal delivery of verapamil hydrochloride

2018 ◽  
Vol 8 (6) ◽  
pp. 16-21
Author(s):  
NEHA JAIN ◽  
Ameeta Argal ◽  
Girendra Gautam
Keyword(s):  
Transdermal Delivery ◽  
Skin Permeation ◽  
Entrapment Efficiency ◽  
Sprague Dawley ◽  
Rat Skin ◽  
Verapamil Hydrochloride ◽  
In Vitro Skin Permeation ◽  
Permeation Studies ◽  
Elastic Vesicles

The aim of present investigation was to formulate and characterize elastic liposomes as a delivery system for transdermal delivery of Verapamil hydrochloride, a drug having low oral bioavailability (approx 20%), short biological half-life and extensive first pass metabolism.Verapamil hydrochloride loaded elastic vesicles were prepared by a slightly modified extrusion method using soya phosphatidylcholine and span 80(edge activator). Prepared elastic vesicles were characterized for various parameters such as vesicle shape, vesicle size and size distribution, entrapment efficiency, elasticity measurements, stability studies and in vitro skin permeation studies through excised rat skin (Sprague Dawley) using a locally fabricated Franz diffusion cell. The entrapment efficiency of elastic vesicles was found to be 59.3±3.6%. In vitro skin permeation of verapamil hydrochloride through excised rat skin (Sprague Dawley) revealed that elastic vesicles led to an enhanced transdermal flux (50.2±4.52 mg/cm2/h) of verapamil hydrochloride as compared to liposomes (11.6±2.12mg/cm2/h). Decreased lag time (0.9 h) was also observed in case of elastic liposomes. Our results indicate the feasibility of elastic liposomes for transdermal delivery of verapamil hydrochloride for improved skin permeation. Keywords: Transdermal delivery, Elastic liposomes, Verapamil hydrochloride.  

scholarly journals Physical Characterizations and In Vitro Skin Permeation of Elastic Liposomes for Transdermal Delivery of Polygonum aviculare L. Extract

Polymer Korea ◽  
2014 ◽  
Vol 38 (6) ◽  
pp. 694-701 ◽  
Author(s):  
Saet Byeol Han ◽  
Soon Sik Kwon ◽  
Yoo Min Jeong ◽  
Bong Ju Kong ◽  
Eun Ryeong Yu ◽  
...  
Keyword(s):  
Transdermal Delivery ◽  
Skin Permeation ◽  
Polygonum Aviculare ◽  
In Vitro Skin Permeation
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