Diverse effects of P-glycoprotein inhibitory agents on human leukemia cells expressing the multidrug resistance protein (MRP)

2000 ◽  
Vol 38 (04) ◽  
pp. 187-195 ◽  
Author(s):  
G. Lehne ◽  
L. Mrrkrid ◽  
M. den Boer ◽  
H.E. Rugstad
Keyword(s):  
Multidrug Resistance ◽  
Leukemia Cells ◽  
Human Leukemia ◽  
Multidrug Resistance Protein ◽  
Human Leukemia Cells ◽  
P Glycoprotein ◽  
Resistance Protein ◽  
Inhibitory Agents

scholarly journals Interactions of Ofloxacin and Erythromycin with the Multidrug Resistance Protein (MRP) in MRP-Overexpressing Human Leukemia Cells

2000 ◽  
Vol 44 (6) ◽  
pp. 1697-1700 ◽  
Author(s):  
Kenji Terashi ◽  
Mikio Oka ◽  
Hiroshi Soda ◽  
Minoru Fukuda ◽  
Shigeru Kawabata ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Antimicrobial Agents ◽  
Efflux Pump ◽  
Human Leukemia ◽  
Multidrug Resistance Protein ◽  
Enhanced Sensitivity ◽  
Human Leukemia Cells ◽  
Calcein Am ◽  
Resistance Protein ◽  
Drug Efflux Pump

ABSTRACT To investigate interactions between the multidrug resistance protein (MRP) and antimicrobial agents, we examined the effects of 12 agents on vincristine sensitivity and efflux of the calcein acetoxy-methyl ester (calcein-AM) of a MRP substrate in MRP-overexpressing cells. Only ofloxacin and erythromycin enhanced sensitivity with increased intracellular vincristine accumulation and inhibited the calcein-AM efflux. Our findings suggest that the two agents are possible MRP substrates and may competitively inhibit MRP function as a drug efflux pump.

P-Glycoprotein Antibody Functionalized Carbon Nanotube Overcomes the Multidrug Resistance of Human Leukemia Cells

ACS Nano ◽  
2010 ◽  
Vol 4 (3) ◽  
pp. 1399-1408 ◽  
Author(s):  
Ruibin Li ◽  
Ren’an Wu ◽  
Liang Zhao ◽  
Minghuo Wu ◽  
Ling Yang ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Carbon Nanotube ◽  
Leukemia Cells ◽  
Human Leukemia ◽  
Human Leukemia Cells ◽  
P Glycoprotein ◽  
Functionalized Carbon Nanotube

Multidrug resistance protein P-glycoprotein does not recognize nanoparticle C60: experiment and modeling

Soft Matter ◽  
2012 ◽  
Vol 8 (10) ◽  
pp. 2915 ◽  
Author(s):  
Xue Xu ◽  
Ruibin Li ◽  
Ming Ma ◽  
Xia Wang ◽  
Yonghua Wang ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Multidrug Resistance Protein ◽  
P Glycoprotein ◽  
Resistance Protein

Comparison of Furosemide and Vinblastine Secretion from Cell Lines Overexpressing Multidrug Resistance Protein (P-Glycoprotein) and Multidrug Resistance-Associated Proteins (MRP1 and MRP2)

Pharmacology ◽  
2002 ◽  
Vol 64 (3) ◽  
pp. 126-134 ◽  
Author(s):  
Shawn D. Flanagan ◽  
Carolyn L. Cummins ◽  
Miki Susanto ◽  
Xiaoli Liu ◽  
Lori H. Takahashi ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Cell Lines ◽  
Multidrug Resistance Protein ◽  
P Glycoprotein ◽  
Associated Proteins ◽  
Resistance Protein
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