scholarly journals Case report: Infected foot ulcer and methicillin-resistant staphylococcus aureus bacteremia in a diabetic patient

2019 ◽  
Vol 6 (2) ◽  
pp. 20
Author(s):  
Margarita Goula ◽  
Patricia Felix ◽  
Meta-Celestine Mbuyamba ◽  
Benoit Pirotte
Keyword(s):  
Staphylococcus Aureus ◽  
Diabetic Patient ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Diagnostic Tools ◽  
Methicillin Resistant ◽  
Staphylococcus Aureus Bacteremia ◽  
Peripheral Arterial ◽  
The Right

Diabetic foot ulcer is one of the most frequent complications affecting the diabetic patient. While there has been considerable progress regarding the diagnostic tools and the range of antibiotic choices, the outcome is often unsatisfactory, the presence of peripheral arterial occlusive disease being among the main factors influencing the evolution. This paper describes the management of a patient presenting with an infected foot ulcer and persistent methicillin-resistant Staphylococcus aureus bacteremia, furthercomplicated by spondylodiskitis and infectious endocarditis: the case gives an opportunity to review the literature in search of theoptimal care and the right treatment choices.

Methicillin-Resistant Staphylococcus aureus Endocarditis from a Diabetic Foot Ulcer

2018 ◽  
Vol 108 (6) ◽  
pp. 528-531 ◽  
Author(s):  
Andrew J. Hale ◽  
Emily Vicks ◽  
Mary T. LaSalvia ◽  
John M. Giurini ◽  
Adolf W. Karchmer
Keyword(s):  
Staphylococcus Aureus ◽  
Diabetic Foot ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
The United States ◽  
Foot Ulcers ◽  
Diabetic Foot Ulcers ◽  
Methicillin Resistant ◽  
Diabetic Foot Infections

Diabetic foot infections are a common cause of morbidity and mortality in the United States, and successful treatment often requires an aggressive and prolonged approach. Recent work has elucidated the importance of appropriate therapy for a given severity of diabetic foot infection, and highlighted the ongoing risk such patients have for subsequent invasive life-threatening infection should diabetic foot ulcers fail to heal. The authors describe the case of a man with diabetes who had prolonged, delayed healing of a diabetic foot ulcer. The ulcer subsequently became infected by methicillin-resistant Staphylococcus aureus (MRSA). The infection was treated conservatively with oral therapy and minimal debridement. Several months later, he experienced MRSA bloodstream infection and complicating endocarditis. The case highlights the ongoing risk faced by patients when diabetic foot ulcers do not heal promptly, and emphasizes the need for aggressive therapy to promote rapid healing and eradication of MRSA.

scholarly journals Oral carriage of methicillin-resistant Staphylococcus aureus strains among patients with diabetic foot ulcer

2020 ◽  
pp. 5-12
Keyword(s):  
Staphylococcus Aureus ◽  
Oral Cavity ◽  
Diabetic Foot ◽  
Antimicrobial Agents ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Diabetic Patients ◽  
Methicillin Resistant ◽  
Mrsa Strains

Introduction: Diabetic foot ulcer (DFU) caused by Staphylococcus aureus is one of the most feared complications of diabetes mellitus. The studies reporting the oral cavity as a potential reservoir of S. aureus in diabetic patients are sparse. The aim of the study was to compare the prevalence of methicillin-resistant Staphylococcus aureus strains in the oral and in the diabetic foot specimens from DFU patients. Materials and Methods: A total 80 specimens (40 oral swabs and 40 DFU swabs) were collected from diabetic patients with foot ulcer. The specimens were subcultured and the susceptibility of isolated S. aureus strains to antimicrobial agents was determined. Suspected methicillin-resistant S. aureus (MRSA) strains were further examined for the presence of modified PBP2a protein. Results: Less than one-fifth of patients with DFU had oral S. aureus carriage, however the colonization is significantly associated with S. aureus diabetic foot infection. S. aureus strains were isolated from 52.5% of DFU specimens, 17.5% were resistant to methicillin. S. aureus strains were isolated from 17.5% of oral specimens of diabetic patients; 2.5% were methicillin-resistant. The MRSA strains were isolated sevenfold more frequently from the diabetic foot than from the oral cavity. Conclusions: Although diabetic foot infections caused by an endogenous S. aureus strains colonizing the oral cavity of diabetic patients seems unlikely, it is evidently important to monitor the oral S. aureus carriage in diabetic patients and their resistance to antibiotics.

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