scholarly journals Not everything it looks like is! - regarding a case of pulmonary embolization.

Author(s):  
Joana Vaz ◽  
Sara Morgado
1961 ◽  
Vol 06 (01) ◽  
pp. 025-036 ◽  
Author(s):  
James W. Hampton ◽  
William E. Jaques ◽  
Robert M. Bird ◽  
David M. Selby

Summary1. Infusions containing particulate matter, viz. whole amniotic fluid, amniotic fluid sediment, and glass beads, produce in dogs changes in both early and late phases of the clotting reaction. These changes are associated with the development of pulmonary hypertension.2. When dogs were given an active fibrinolysin followed by an infusion of whole amniotic fluid, the alterations in the clotting mechanism were either delayed or did not appear. No pulmonary hypertension developed in these animals.3. We infer that infusions containing particulate matter will produce in dogs both pulmonary hypertension and changes in the clotting mechanism. Although these are independent changes, both are as closely related to the damage to the pulmonary vessels as they are to the biological nature of the infusions.


1960 ◽  
Vol 198 (3) ◽  
pp. 543-546 ◽  
Author(s):  
S. A. Kabins ◽  
J. Fridman ◽  
J. Neustadt ◽  
G. Espinosa ◽  
L. N. Katz

A localized pulmonary infarction was produced by injecting a starch suspension into the pulmonary artery wedge position of one lung lobe in pentobarbitalized dogs, and the effect of three so-called antiserotonins on the ensuing pulmonary edema was determined. Edema was inhibited in the nonembolized lung lobes in 88% of the B.A.S. (1-benzyl-2-methyl-5-methoxytryptamine HCl), 45% of the DHE (dihydroergotamine), and 12% of the BOL (2-brom- d-lysergic acid diethylamide) dogs. Reasons are given for assuming that the actions of B.A.S. and DHE are due to their antiadrenergic rather than to any antiserotonin properties which they may have. Serotonin, therefore, at most has a slight role in the pulmonary edema formation caused by starch emboli. It is postulated that the emboli by producing an infarct and setting up a reflex mediated through the sympathetic nervous system, cause the release in turn of catecholamines and of histamine, the latter being immediately responsible for the capillary permeability change leading to pulmonary edema.


1985 ◽  
Vol 6 (1) ◽  
pp. 77-81
Author(s):  
Stephen E. Brown ◽  
Richard W. Light

1961 ◽  
Vol 16 (5) ◽  
pp. 842-846 ◽  
Author(s):  
Alan D. Horres ◽  
Theodore Bernthal

During continuous spirometric recording of breathing, 75–μ glass bead emboli were delivered selectively to single lungs or lung lobes while the remaining lung areas were maintained functionally intact and free of emboli. Postmortem digestion of the lungs revealed the distribution of the emboli and demonstrated complete localization within single lungs or lobes in 12 of 16 experiments. In all instances the frequency of breathing increased and tidal air decreased in a pattern indistinguishable from that attending bilateral multiple minute pulmonary embolism. These effects were abolished by vagotomy but survived inhalation of pure oxygen. Comparison of the quantitative relationship between emboli dose and magnitude of response in localized with that in generalized pulmonary embolization suggests that, within limits, the intensity of the tachypnea is determined by the number of emboli injected regardless of the identity of the gross lung area in which they lodge or the degree of their concentration or dispersion within areas in which they lodge and seems not to favor associated hemodynamic factors as the agency initiating the reflex. Submitted on January 3, 1961


2019 ◽  
Vol 107 (4) ◽  
pp. e245-e246 ◽  
Author(s):  
Vera N. Merli ◽  
Sonia Dell’Oglio ◽  
Valentina Grazioli ◽  
Cristian Monterosso ◽  
Benedetta Vanini ◽  
...  

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Avni Shah ◽  
Naheed Ansari ◽  
Zaher Hamadeh

Number of patients with End Stage Renal Disease (ESRD) is growing worldwide. Hemodialysis remains the main modality of renal replacement therapy for ESRD patients. A patent hemodialysis access (arteriovenous fistula or arteriovenous graft) plays a key role in successful delivery of hemodialysis. Common vascular access issues encountered by patients and nephrologists are thrombosis and infection. The thrombosed access is declotted by various percutaneous techniques these days by multiple outpatient access centers in a timely fashion. Thrombolysis can give rise to various complications, a few of which can be life threatening. A young hemodialysis patient underwent percutaneous thrombolysis of his clotted arteriovenous fistula. Outpatient access thrombectomy was complicated immediately afterwards with cardiac arrest requiring cardiac resuscitation in the recovery room. The patient was admitted to intensive care unit after life sustaining care. Work up revealed multiple pulmonary emboli to both lung fields on CT scan of the chest. Patient was anticoagulated and discharged from the hospital. Thrombolysis of clotted hemodialysis access is associated commonly with occurrences of pulmonary embolic which are usually asymptomatic. Massive pulmonary embolization due to access thrombolysis is rare. Nephrologists and radiologists should be aware of this dangerous complication particularly in patients with preexisting cardiopulmonary disease.


2003 ◽  
Vol 127 (2) ◽  
pp. e67-e69
Author(s):  
Denis M. McCarthy ◽  
Mark Haas ◽  
Paul J. Thuluvath ◽  
Jeff F. Geschwind ◽  
Grover M. Hutchins ◽  
...  

Abstract A bovine collagen matrix is sometimes used as a delivery medium during direct intratumoral injection of a chemotherapeutic agent. The bovine collagen enhances the dose and duration of local drug delivery and limits systemic toxicity. Although this strategy is advocated as a means of easy and effective delivery of chemotherapeutic drugs, the associated risks are not well defined. We report the case of a 71-year-old man with hepatocellular carcinoma who underwent weekly intratumoral injections of cisplatin in a bovine collagen matrix. During the third injection, he suddenly and unexpectedly underwent cardiac arrest and died. An autopsy disclosed diffuse occlusion of the pulmonary microcirculation by bovine collagen. The collagen emboli were associated with an inflammatory infiltrate typical of bovine collagen–induced hypersensitivity. This case identifies a fatal complication of intratumoral chemotherapy injections using a bovine collagen matrix, which does not appear to have been previously reported. This case underscores the valuable role of the traditional autopsy examination as a means of identifying possible complications of novel oncologic strategies, which are being rapidly developed and implemented.


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