Between Genoa and Milan: Giovanni Maria Visconti and His Hagiography of Anton Giulio Brignole Sale (1666)

Giovanni Maria Visconti, member of a prominent family of the Milanese patriciate, had an important career in his order as a teacher and spiritual director, and a valuable role in the internal government of the Society, between Milan and Genoa. After the death of Anton Giulio Brignole Sale, he was charged by his superiors with the task of writing a hagiographic biography of this famous man of letters and politician (son of a Genoese duke) who, after a long cursus honorum in the public offices of his republic and during a period of political crisis of the Genoese state, decided to end his career to become a diocesan priest, and, some years later, a member of the Society of Jesus. The work was published in 1666, with the title Alcune memorie delle virtù del padre Anton Giulio Brignole (Some memoirs of the virtues of Father Anton Giulio Brignole). It is an interesting book especially because the author, while describing Brignole Sale’s life and heroic virtues, also explained his transformation from the role of Catholic statesman to the role of religious preacher.

Retinal Neurodegeneration in Different Risk Phenotypes of Diabetic Retinal Disease

Diabetic retinopathy (DR) has been considered a microvascular disease, but it has become evident that neurodegeneration also plays a key role in this complex pathology. Indeed, this complexity is reflected in its progression which occurs at different rates in different type 2 diabetic (T2D) individuals. Based on this concept, our group has identified three DR progression phenotypes that might reflect the interindividual differences: phenotype A, characterized by low microaneurysm turnover (MAT <6), phenotype B, low MAT (<6) and increased central retinal thickness (CRT); and phenotype C, with high MAT (≥6). In this study, we evaluated the progression of DR neurodegeneration, considering ganglion cell+inner plexiform layers (GCL+IPL) thinning, in 170 T2D individuals followed for a period of 5 years, to explore associations with disease progression or risk phenotypes. Ophthalmological examinations were performed at baseline, first 6 months, and annually. GCL+IPL average thickness was evaluated by optical coherence tomography (OCT). Microaneurysm turnover (MAT) was evaluated using the RetMarkerDR. ETDRS level and severity progression were assessed in seven-field color fundus photography. In the overall population there was a significant loss in GCL+IPL (−0.147 μm/year), independently of glycated hemoglobin, age, sex, and duration of diabetes. Interestingly, this progressive thinning in GCL + IPL reached higher values in phenotypes B and C (−0.249 and −0.238 μm/year, respectively), whereas phenotype A remained relatively stable. The presence of neurodegeneration in all phenotypes suggests that it is the retinal vascular response to the early neurodegenerative changes that determines the course of the retinopathy in each individual. Therefore, classification of different DR phenotypes appears to offer relevant clarification of DR disease progression and an opportunity for improved management of each T2D individual with DR, thus playing a valuable role for the implementation of personalized medicine in DR.

Unspoiled Identities of People Living Alone With Dementia: Resisting Stigma by Helping Others

Goffman (1963) described stigma as the shift from being viewed as a whole and usual person to one with a spoiled identity. People living with dementia (PLWD) often report feeling stigmatized. Many dementia stereotypes highlight losses (e.g., loss of self) and negatively position the person as a passive, dependent care recipient. Here, we present findings from a qualitative study of people living alone with dementia (N=10) in the community that challenge these stereotypes. Analysis of in-depth interviews revealed that many participants resisted the spoiled identity label through active engagement in the community such as participating in paid employment, providing care for neighbors and family members, and volunteering. Overall, findings underscore the need to rethink and challenge common perceptions of PLWD that are focused solely on care, to recognize their active and valuable role in the lives of others. How PLWD negotiate these identities should inform policies of dementia in community.

‘Technology is Everywhere, we have the Opportunity to Learn it in the Valley’: The Appropriation of a Socio-Technical Enabling Infrastructure in the Moroccan High Atlas

This paper describes the appropriation processes involved in establishing a socio-technical enabling infrastructure in a valley in the High Atlas of Morocco. We focus on the challenges of co-establishing such an intervention in a rural/mountainous region that is already undergoing a process of continuous development and profound transformation. We reflect upon the changes and unforeseen appropriation by our local partners and inhabitants in the valley of a computer club primarily used as an informal learning centre for school children. We followed an ethnographic approach and combined research perspectives from both socio-informatics and anthropology. This paper sheds light on what a successful cooperation and intervention in this kind of challenging environment can look like. It does this by taking seriously competing expectations, fragile infrastructural foundations and the socio-cultural context. Despite the challenges, the intervention managed to lead to the establishment of a socio-technical enabling infrastructure that plays a particularly valuable role in local educational endeavours and that is now moving towards supporting other members of the community. The paper thus provides insights regarding what has to be considered to create a mutually beneficial cooperation with all relevant stakeholders as well as a sustainable intervention.

Community Orchards for Food Sovereignty, Human Health, and Climate Resilience: Indigenous Roots and Contemporary Applications

Community orchards could play a valuable role as nature-based solutions to complex challenges we face today. In these unique plantings, a variety of nut- and fruit-producing trees and berry shrubs are often established together on public spaces to provide the community with healthy, fresh food. Interest in these plantings has been increasing in the United States, even more so since the COVID-19 pandemic highlighted vulnerabilities in our food systems. However, the roots of community orchards can be traced back to Indigenous foodways which have persisted for millennia. Then and now, community orchards support an array of functions, positioning them to contribute to solutions to major challenges related to food security, human health, and climate resilience. In this paper, contemporary applications are considered for Indigenous communities in the US that seek to care for their communities and the environment. A case study of the Osage Orchard project in Pawhuska, OK, USA, highlights the value of reconnecting with cultural foods and practices of Osage ancestors, to meet the needs and preferences of a contemporary Indigenous community.

Describing the indirect impact of COVID-19 on healthcare utilisation using syndromic surveillance systems

Background Since the end of January 2020, the coronavirus (COVID-19) pandemic has been responsible for a global health crisis. In England a number of non-pharmaceutical interventions have been introduced throughout the pandemic, including guidelines on healthcare attendance (for example, promoting remote consultations), increased handwashing and social distancing. These interventions are likely to have impacted the incidence of non–COVID-19 conditions as well as healthcare seeking behaviour. Syndromic Surveillance Systems offer the ability to monitor trends in healthcare usage over time. Methods This study describes the indirect impact of COVID-19 on healthcare utilisation using a range of syndromic indicators including eye conditions, mumps, fractures, herpes zoster and cardiac conditions. Data from the syndromic surveillance systems monitored by Public Health England were used to describe the number of contacts with NHS 111, general practitioner (GP) In Hours (GPIH) and Out-of-Hours (GPOOH), Ambulance and Emergency Department (ED) services over comparable periods before and during the pandemic. Results The peak pandemic period in 2020 (weeks 13–20), compared to the same period in 2019, displayed on average a 12% increase in NHS 111 calls, an 11% decrease in GPOOH consultations, and a 49% decrease in ED attendances. In the GP In Hours system, conjunctivitis consultations decreased by 64% and mumps consultations by 31%. There was a 49% reduction in attendance at EDs for fractures, and there was no longer any weekend increase in ED fracture attendances, with similar attendance patterns observed across each day of the week. There was a decrease in the number of ED attendances with diagnoses of myocardial ischaemia. Conclusion The COVID-19 pandemic drastically impacted healthcare utilisation for non-COVID-19 conditions, due to a combination of a probable decrease in incidence of certain conditions and changes in healthcare seeking behaviour. Syndromic surveillance has a valuable role in describing and understanding these trends.

Donkey Ownership Provides a Range of Income Benefits to the Livelihoods of Rural Households in Northern Ghana

Donkeys provide important resources and benefits for millions of people worldwide. However, global donkey populations are under increasing pressure from the growing demand for a traditional Chinese medicine, e’jiao, made from donkey-skin. The objective of this reflexive, qualitative thematic analysis was to examine the role of donkeys with 262 participants in northern Ghana and how donkeys contribute to livelihood outcomes, especially their use by women and children. Data was collected from four surveys, 12 in-depth interviews and 84 daily time budgets with the same participants, plus 16 focus groups, during one wet and one dry season across 2018-19. Uniquely, boys and girls between the ages of 10–16-years old were interviewed. Donkeys are highly valued by their owners as they play a valuable role in providing a pathway out of ultra-poverty. Donkeys’ contributions to livelihoods are significant and more complex than previously understood and documented in the literature. Donkey ownership confers up to six different income benefits in comparison to non-donkey owners. Female owners of donkeys reported that donkeys can contribute between 30–60% of their income. Children of both sexes can play an important role in the efficient deployment of one of these income generating activities.

Contextualizing Malaysia’s Cybersecurity Agenda

This chapter reviews Malaysia’s approach to cybersecurity. It begins by considering the country’s economic priorities, which have been and will remain the catalyst for the government’s push into cyberspace and, consequently, the development of its cybersecurity capabilities. The chapter then examines the government’s efforts to secure those economic priorities by protecting its critical national information infrastructure. It explores the country’s nation-building agenda in cyberspace, as well as the resultant tensions between keeping the Internet free and open for robust digital innovation on the one hand and preserving political stability and security on the other. The chapter also provides a brief overview of other cybersecurity trends in Malaysia, including cybercrime and hacking. Even though Malaysia played an active and valuable role in the United Nations (UN) Group of Governmental Experts (GGE) on Developments in the Field of Information and Telecommunications in the Context of International Security from 2015 to 2016, the government’s emphasis on the economic benefits of cyberspace has narrowed its focus to preserving and optimizing the technical utility of the Internet in order to facilitate the digital economy.

Agency as Rhetorical Device in the Discourse of kids Animated Learning Videos on Covid- 19 Virus

At Covid-19 pandemic, people worldwide were attacked by a dangerous and widely spread virus known as Coronavirus. Kids are not matured enough to understand why they have to stay home and follow health instructions. Animated learning videos are designed for kids for the purpose of making them aware of the virus. The objectives of the present study are: (1) Examining one of Burke’s pentad (1969) represented by ”agency,” in Covid-19 kids videos, (2) Investigating the rhetorical devices used in the selected data to inform, persuade and make kids aware of what is meant by covid-19, (3) Revealing the dominant rhetorical device. The main question that arises here is; “what are the rhetorical strategies used in the discourse of the learning videos on Covid-19”. The selected data is limited to the discourse of six kids’ videos dealing with covid-19 found on YouTube. The theories followed in the analysis are Tarigan’s theory (2013) and Burke’s pentad (1969). The results revealed that the discourse of each video reflects a dramatic situations, including the pentad items; act, scene, agent, agency, and purpose. It is also found that agency as a rhetorical device is highly used in the selected data and the most dominant device was personification. It is concluded that the use of the dramatic situations and rhetorical devices in such videos has a valuable role in making kids aware of what is meant by Covid-19 pandemic and persuaded why they have to follow the safety instructions, leaving schools and stay home.

MAP/Microtubule Affinity Regulating Kinase 4 Inhibitory Potential of Irisin: A New Therapeutic Strategy to Combat Cancer and Alzheimer’s Disease

Irisin is a clinically significant protein playing a valuable role in regulating various diseases. Irisin attenuates synaptic and memory dysfunction, highlighting its importance in Alzheimer’s disease. On the other hand, Microtubule Affinity Regulating Kinase 4 (MARK4) is associated with various cancer types, uncontrolled neuronal migrations, and disrupted microtubule dynamics. In addition, MARK4 has been explored as a potential drug target for cancer and Alzheimer’s disease therapy. Here, we studied the binding and subsequent inhibition of MARK4 by irisin. Irisin binds to MARK4 with an admirable affinity (K = 0.8 × 107 M−1), subsequently inhibiting its activity (IC50 = 2.71 µm). In vitro studies were further validated by docking and simulations. Molecular docking revealed several hydrogen bonds between irisin and MARK4, including critical residues, Lys38, Val40, and Ser134. Furthermore, the molecular dynamic simulation showed that the binding of irisin resulted in enhanced stability of MARK4. This study provides a rationale to use irisin as a therapeutic agent to treat MARK4-associated diseases.