Pulmonary Embolization of Bovine Collagen

2003 ◽  
Vol 127 (2) ◽  
pp. e67-e69
Author(s):  
Denis M. McCarthy ◽  
Mark Haas ◽  
Paul J. Thuluvath ◽  
Jeff F. Geschwind ◽  
Grover M. Hutchins ◽  
...  
Keyword(s):  
Collagen Matrix ◽  
Intratumoral Injection ◽  
Local Drug Delivery ◽  
Bovine Collagen ◽  
Effective Delivery ◽  
Autopsy Examination ◽  
Pulmonary Embolization ◽  
Pulmonary Microcirculation ◽  
Valuable Role

Abstract A bovine collagen matrix is sometimes used as a delivery medium during direct intratumoral injection of a chemotherapeutic agent. The bovine collagen enhances the dose and duration of local drug delivery and limits systemic toxicity. Although this strategy is advocated as a means of easy and effective delivery of chemotherapeutic drugs, the associated risks are not well defined. We report the case of a 71-year-old man with hepatocellular carcinoma who underwent weekly intratumoral injections of cisplatin in a bovine collagen matrix. During the third injection, he suddenly and unexpectedly underwent cardiac arrest and died. An autopsy disclosed diffuse occlusion of the pulmonary microcirculation by bovine collagen. The collagen emboli were associated with an inflammatory infiltrate typical of bovine collagen–induced hypersensitivity. This case identifies a fatal complication of intratumoral chemotherapy injections using a bovine collagen matrix, which does not appear to have been previously reported. This case underscores the valuable role of the traditional autopsy examination as a means of identifying possible complications of novel oncologic strategies, which are being rapidly developed and implemented.

Effect of a bovine collagen matrix on tendon adhesions during the repair of rat Achilles tendon

2021 ◽  
Author(s):  
M. Gürler ◽  
T. Aksan ◽  
M.B. Özturk ◽  
M. Tezcan ◽  
A.N. Toksöz Yıldırım ◽  
...  
Keyword(s):  
Achilles Tendon ◽  
Collagen Matrix ◽  
Bovine Collagen

scholarly journals ’n Prakties-teologiese ondersoek na die kerklike jaar in die prediking van die Nederduitse Gereformeerde Kerk

2005 ◽  
Vol 61 (4) ◽  
Author(s):  
G. Bothma
Keyword(s):  
Dutch Reformed ◽  
Nederduitse Gereformeerde Kerk ◽  
Christian Worship ◽  
Practical Theological ◽  
The Church ◽  
Valuable Role

A practical-theological investigation into the role of the church year in the liturgy and preaching of the Dutch Reformed ChurchThe aim of this article is to discuss the valuable role the church year can play in liturgy and preaching and the service and activities of the church. The article demonstrates that the rediscovery of the church year is one of the most remarkable aspects of the twentiethcentury reform and renewal of Christian worship. Within a context of poverty and continuing change, the church year – if valued positively and if accentuated in the preaching – could lead to the celebration of God.

scholarly journals Environmental Surveillance through Next-Generation Sequencing to Unveil the Diversity of Human Enteroviruses beyond the Reported Clinical Cases

Viruses ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 120
Author(s):  
Andrés Lizasoain ◽  
Daiana Mir ◽  
Gisella Masachessi ◽  
Adrián Farías ◽  
Nélida Rodríguez-Osorio ◽  
...  
Keyword(s):  
Next Generation Sequencing ◽  
Next Generation ◽  
Echovirus 30 ◽  
Coxsackievirus B4 ◽  
Important Region ◽  
Enterovirus A71 ◽  
Wastewater Samples ◽  
Valuable Role ◽  
Generation Sequencing

The knowledge about circulation of Human Enteroviruses (EVs) obtained through medical diagnosis in Argentina is scarce. Wastewater samples monthly collected in Córdoba, Argentina during 2011–2012, and then in 2017–2018 were retrospectively studied to assess the diversity of EVs in the community. Partial VP1 gene was amplified by PCR from wastewater concentrates, and amplicons were subject of next-generation sequencing and genetic analyses. There were 41 EVs detected, from which ~50% had not been previously reported in Argentina. Most of the characterized EVs (60%) were detected at both sampling periods, with similar values of intratype nucleotide diversity. Exceptions were enterovirus A71, coxsackievirus B4, echovirus 14, and echovirus 30, which diversified in 2017–2018. There was a predominance of types from EV-C in 2017–2018, evidencing a common circulation of these types throughout the year in the community. Interestingly, high genetic similarity was evidenced among environmental strains of echovirus 30 circulating in 2011–2012 and co-temporal isolates obtained from patients suffering aseptic meningitis in different locations of Argentina. This study provides an updated insight about EVs circulating in an important region of South America, and suggests a valuable role of wastewater-based epidemiology in predicting outbreaks before the onset of cases in the community.

scholarly journals Increasing Referral and Participation Rates to Outpatient Cardiac Rehabilitation: The Valuable Role of Healthcare Professionals in the Inpatient and Home Health Settings

Circulation ◽  
2012 ◽  
Vol 125 (10) ◽  
pp. 1321-1329 ◽  
Author(s):  
Ross Arena ◽  
Mark Williams ◽  
Daniel E. Forman ◽  
Lawrence P. Cahalin ◽  
Lola Coke ◽  
...  
Keyword(s):  
Cardiac Rehabilitation ◽  
Healthcare Professionals ◽  
Home Health ◽  
Participation Rates ◽  
Valuable Role

scholarly journals Role of collagen membrane in lateral onlay grafting with bovine hydroxyapatite incorporated with collagen matrix in dogs

2013 ◽  
Vol 43 (2) ◽  
pp. 64 ◽  
Author(s):  
Ui-Won Jung ◽  
Jung-Seok Lee ◽  
Geun Lee ◽  
In-Kyeong Lee ◽  
Ji-Wan Hwang ◽  
...  
Keyword(s):  
Collagen Matrix ◽  
Collagen Membrane ◽  
Bovine Hydroxyapatite

scholarly journals The taxonomy, biogeography and conservation of the myrmecophilous Chrysoritis butterflies (Lepidoptera: Lycaenidae) in South Africa

Koedoe ◽  
2003 ◽  
Vol 46 (2) ◽  
Author(s):  
R.F. Terblanche ◽  
H. Van Hamburg
Keyword(s):  
South Africa ◽  
National Parks ◽  
Paradigm Shift ◽  
Butterfly Species ◽  
Conservation Action ◽  
Research Fields ◽  
Species Lists ◽  
Species Groups ◽  
Valuable Role

The relevance and integration of scientific knowledge to conservation management of the locally popular and highly endemic butterfly genus Chrysoritis are investigated within the research fields of taxonomy and biogeography. The butterfly genus Chrysoritis contains at least 41 species endemic to South Africa. The taxonomy of Chrysoritis has reached a state where revisions could easily result in a plethora of names between “lumping and splitting”. In practice, the state of the taxonomy of these butterflies on species level may alter their conservation priority. The two most species rich species groups in Chrysoritis have different centres of endemism, however, a butterfly atlas becomes a necessity to reveal more about their biogeography. There is an absence of butterfly species lists in many of our National Parks and Nature Reserves. Legislation should facilitate rather than limit the valuable role of the amateur lepidopterist to add distribution records. In turn, the amateur lepidopterists should adapt and make an effort to explore unknown localities, apart from monitoring butterflies at their well-known localities. The red listing of localised butterflies in South Africa, including a number of Chrysoritis species, is in need of an urgent review in the light of the most recent IUCN categories. A species such as Chrysoritis dicksoni should be protected by law - but at its known localities. The scenario that real conservation action is only needed if the last known locality of a butterfly is threatened, should be abolished. A paradigm shift to conserve the metapopulations of the highly endemic Chrysoritis genus and not merely a few of its species as items that appear on lists, seems necessary.

Pharmacist-Initiated Management of a Suspected Case of Risperidone-Induced Neuroleptic Malignant Syndrome in an Aged-Care Resident. The Role of Residential Medication Management Reviews in Medication Safety

2018 ◽  
Vol 33 (3) ◽  
pp. 382-385 ◽  
Author(s):  
Michael Morcos ◽  
Jonathan Corns ◽  
Jodie Belinda Hillen
Keyword(s):  
Medication Safety ◽  
Psychological Symptoms ◽  
Medication Management ◽  
Aged Care ◽  
Suspected Case ◽  
Medication Reviews ◽  
Behavioral And Psychological Symptoms ◽  
Valuable Role

A 70-year-old female aged-care resident was referred by her general practitioner for a residential medication management review after nurses reported difficulties with swallowing, episodes of hyperthermia, elevated blood pressure, and tachycardia. These symptoms were accompanied by increasing confusion and drowsiness. Risperidone had recently been prescribed to treat behavioral and psychological symptoms of dementia. This case study describes the pharmacist-initiated management of the symptoms through a national medication review program. It demonstrates the valuable role collaborative medication reviews play in managing adverse drug reactions in aged-care.

scholarly journals Dual oxidase 1 limits the IFNγ-associated antitumor effect of macrophages

2020 ◽  
Vol 8 (1) ◽  
pp. e000622
Author(s):  
Lydia Meziani ◽  
Marine Gerbé de Thoré ◽  
Pauline Hamon ◽  
Sophie Bockel ◽  
Ruy Andrade Louzada ◽  
...  
Keyword(s):  
Antitumor Effect ◽  
Therapeutic Strategy ◽  
Critical Role ◽  
Tumor Development ◽  
Intratumoral Injection ◽  
Histocompatibility Complex ◽  
Dual Oxidase

BackgroundMacrophages play pivotal roles in tumor progression and the response to anticancer therapies, including radiotherapy (RT). Dual oxidase (DUOX) 1 is a transmembrane enzyme that plays a critical role in oxidant generation.MethodsSince we found DUOX1 expression in macrophages from human lung samples exposed to ionizing radiation, we aimed to assess the involvement of DUOX1 in macrophage activation and the role of these macrophages in tumor development.ResultsUsing Duox1−/− mice, we demonstrated that the lack of DUOX1 in proinflammatory macrophages improved the antitumor effect of these cells. Furthermore, intratumoral injection of Duox1−/− proinflammatory macrophages significantly enhanced the antitumor effect of RT. Mechanistically, DUOX1 deficiency increased the production of proinflammatory cytokines (IFNγ, CXCL9, CCL3 and TNFα) by activated macrophages in vitro and the expression of major histocompatibility complex class II in the membranes of macrophages. We also demonstrated that DUOX1 was involved in the phagocytotic function of macrophages in vitro and in vivo. The antitumor effect of Duox1−/− macrophages was associated with a significant increase in IFNγ production by both lymphoid and myeloid immune cells.ConclusionsOur data indicate that DUOX1 is a new target for macrophage reprogramming and suggest that DUOX1 inhibition in macrophages combined with RT is a new therapeutic strategy for the management of cancers.

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