Vitamin E improves quality of life in patients with alcoholic liver disease

2016 ◽  
Vol 6 (4) ◽  
pp. 269 ◽  
Author(s):  
Bhanu Kolasani ◽  
Prasanand Sasidharan ◽  
Divyashanthi M ◽  
Adithiya Kumar
Keyword(s):  
Quality Of Life ◽  
Liver Disease ◽  
Vitamin E ◽  
Alcoholic Liver Disease

scholarly journals Assessment of Health-Related Quality of Life in Alcoholic Liver Disease Patients

2020 ◽  
Vol 11 (SPL4) ◽  
pp. 1889-1894
Author(s):  
Setareh Dastyar Haghighi ◽  
Vandhita Nair ◽  
Vas Sonali Maria ◽  
Gopika K S ◽  
Divya Mol E C ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Liver Disease ◽  
Alcoholic Liver Disease ◽  
Case Report Form ◽  
Health Related Quality ◽  
Mild Depression ◽  
Factors Affecting ◽  
Related Quality ◽  
Health Related

Alcohol induced cirrhosis prevalence has increased worldwide of late and has added markedly to the global burden of diseases. However, research involving quality of life as treatment outcome for alcoholic liver disease is limited. The primary objective of the study was to evaluate the health related quality of life and factors affecting it in alcoholic liver disease patients. Secondary objective was to analyze mental health status and prescription pattern in alcoholic liver disease patients. Patients, eligible to participate, were briefed regarding the purpose of the study and informed consent was obtained. Self-designed case report form and validated questionnaires were used to record information on physical, mental and emotional functioning of the patient. The study included 51 patients. It was found that majority had low quality of life scores with role limitation due to physical health (5.39 ± 16.9) domain being the most affected. It was also found that the symptom fatigue caused the most hindrance to patient’s daily activities (1.31± 1.20). Most of the patients reported having mild depression (50.98%). Prescription analysis showed that diuretics (74.50%) and drugs for hepatic encephalopathy were the most commonly used drugs. The present study found that alcoholic liver disease considerably impaired health related quality of life and identified the contributing factors as presence of complication, age, severity of disease and symptoms like fatigue and abdominal pain. Hence, evaluating factors affecting quality of life and prescription patterns help identify targets for novel treatment strategies.

scholarly journals Evaluation of the effectiveness of the drug Samelix in patients with cholestasis in chronic alcoholic liver disease

2019 ◽  
pp. 52-57
Author(s):  
O. N. Minushkin ◽  
L. V. Maslovsky ◽  
M. I. Bulanova ◽  
O. F. Shaposhnikovа
Keyword(s):  
Quality Of Life ◽  
Liver Disease ◽  
Clinical Efficacy ◽  
Alcoholic Liver Disease ◽  
Biochemical Parameters ◽  
Clinical Manifestations ◽  
Efficacy And Safety ◽  
Chronic Alcoholic ◽  
The Individual

A study of the clinical efficacy and safety of the drug Samelix (ademetionine, manufacturer – JSC «Canonfarma production», Russia) in 30 patients with chronic alcoholic liver disease (steatohepatitis mild to moderate currents, cirrhosis of the liver grade a ChildPugh) with the syndrome of cholestasis. Purpose of the study: evaluate the clinical efficacy and safety of Samelix (ademetionine) in 30 patients with chronic alcoholic liver disease. Objectives of the study: evaluate the effect of the drug on biochemical parameters, evaluate the effect of the drug on the clinical manifestation of the disease based on the individual diary data during the course therapy, assess the quality of life through the SF-36 questionnaire before and after treatment; report adverse events. The results of the study showed that therapy with this drug leads to a significant positive dynamics of biochemical parameters, regression of clinical manifestations of the disease, a significant increase in the quality of life. Good and excellent results of therapy were observed in 76.7% of cases. The drug is safe and well tolerated.

scholarly journals ASSESSMENT OF CLINICAL PROFILE AND TREATMENT CHART REVIEW FOR ALCOHOLIC LIVER DISEASE (ALD) PATIENTS: A PROSPECTIVE AND OBSERVATIONAL STUDY

2018 ◽  
Vol 8 (5) ◽  
pp. 437-441
Author(s):  
Siddaruda Malleshappa Biradar ◽  
Dhanavanti Gelada ◽  
MV Mounika ◽  
P Meghana ◽  
M Bharathi ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Liver Disease ◽  
Drug Therapy ◽  
Observational Study ◽  
Alcoholic Liver Disease ◽  
Chart Review ◽  
Clinical Profile ◽  
Patient Counselling ◽  
Optimal Drug

Background/Aim: Alcohol remains one of most common cause of liver disease in India, hence the present study was undertaken to assess the clinical profile and treatment chart review of alcoholic liver disease (ALD) patients. Materials and Methods: Hospital based prospective and observational study was carried out for a period of nine months in a tertiary care hospital of south India.  All the patients of either gender diagnosed with ALD were enrolled in the study and patient consent was taken, the data related to the patients of ALD were documented in a structured patient data collection form and analyzed carefully. Results: ALD was mainly affected in male with age group of 41-50 years.Out of 130 patients 43.8% patients were suffered from Fatty Liver disease while 23.1% were suffered from Alcoholic Hepatitis and 33.1% were suffered from Cirrhosis of Liver. The secondary developments to ALD were portal hypertension (13.8%) followed by Ascities (10.8%) and Hepatitis (10%). The major risk factors involved in ALD was alcohol per se (52.3%) and, alcohol and smoking exaggerate the disease condition. The Periodic (61.5%) and regular basis (38.5%) of alcoholism for chronic period of time may land up with ALD. Polypharmacy is essential for the treatment of ALD as it inoved multiple secondary development to ALD. The patients were intervened and counselled on their individual basis for ALD consequences, and motivated for cessation of alcohol and smoking. Conclusion: The study enlightens that the early diagnosis and its beneficial outcomes that can exponentially curtail the mortality rate of ALD. Similarly the optimal drug therapy regimen and patient counseling may improve the patient’s quality of life. Keywords: Alcoholic Liver Disease; Optimal Drug Therapy; Patient Counselling; Improved Quality of Life

Quality of life after liver transplantation for alcoholic liver disease

2000 ◽  
Vol 6 (6) ◽  
pp. 762-768 ◽  
Author(s):  
Stephen P. Pereira ◽  
Louise M. Howard ◽  
Paolo Muiesan ◽  
Mohammed Rela ◽  
Nigel Heaton ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Liver Transplantation ◽  
Liver Disease ◽  
Alcoholic Liver Disease

scholarly journals Coping strategies predicting quality of life in diabetic and obese NAFLD patients

2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
J Funuyet-Salas ◽  
A Martín-Rodríguez ◽  
M A Pérez-San-Gregorio ◽  
M Romero-Gómez
Keyword(s):  
Quality Of Life ◽  
Liver Disease ◽  
Coping Strategies ◽  
Physical Component Summary ◽  
Fatty Liver Disease ◽  
Mental Component Summary ◽  
Active Coping ◽  
Self Blame ◽  
Positive Reframing

Abstract Background To date, coping strategies have not been studied in patients with nonalcoholic fatty liver disease (NAFLD), despite evidence of their relevance in chronic liver pathology, Type 2 diabetes mellitus (T2DM) and obesity (OB). We therefore analyzed which coping strategies predicted quality of life in diabetic and obese NAFLD patients. Methods Four hundred and ninety-two biopsy-proven NAFLD patients (290 men and 202 women, mean age 54.90±11.74) were evaluated using The Brief COPE, 12-Item Short-Form Health Survey (SF-12) and Chronic Liver Disease Questionnaire-Non-Alcoholic Fatty Liver Disease (CLDQ-NAFLD). A stepwise multiple linear regression analysis was performed on four groups (G1, n = 335, absence of T2DM; G2, n = 157, presence of T2DM; G3, n = 249, absence of OB; and G4, n = 243, presence of OB) to analyze which coping strategies predicted patient quality of life (physical component summary SF-12, mental component summary SF-12, and total CLDQ-NAFLD). Results In both diabetic and obese patients, active coping (T2DM, p = 0.003, β = 0.26; OB, p = 0.000, β = 0.33) and denial (T2DM, p = 0.027, β=-0.19; OB, p = 0.004, β=-0.18) predicted the physical component summary. Denial (T2DM, p = 0.000, β=-0.30; OB, p = 0.001, β=-0.19), positive reframing (T2DM, p = 0.000, β = 0.28; OB, p = 0.000, β = 0.29), self-blame (T2DM, p = 0.000, β=-0.24; OB, p = 0.000, β=-0.26) and self-distraction (T2DM, p = 0.033, β=-0.13; OB, p = 0.023, β=-0.11) predicted the mental component summary. Denial (T2DM, p = 0.000, β=-0.34; OB, p = 0.000, β=-0.31), positive reframing (T2DM, p = 0.000, β = 0.30; OB, p = 0.005, β = 0.15) and self-blame (T2DM, p = 0.000, β=-0.26; OB, p = 0.000, β=-0.28) also predicted the total CLDQ-NAFLD in both groups. Conclusions Active coping and positive reframing predicted better quality of life, while denial, self-blame and self-distraction predicted worse quality of life in diabetic and obese NAFLD patients, suggesting the inclusion of coping strategies in future multidisciplinary NAFLD treatments. Key messages Importance of coping strategies for NAFLD patients: active coping and positive reframing predicted better quality of life, while denial, self-blame and self-distraction predicted worse quality. This study shows the need to design multidisciplinary strategies for managing NAFLD and improving patient quality of life, in which intervention in coping strategies should be a major element.

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