scholarly journals A case of renal cell carcinoma in a patient with situs inversus: Operative considerations and a review of the literature

2017 ◽  
Vol 11 (5) ◽  
pp. 233 ◽  
Author(s):  
Justin Oake ◽  
Darrel Drachenberg
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Situs Inversus ◽  
Renal Cell ◽  
Left Renal Vein ◽  
Vena Cava ◽  
Mirror Image ◽  
Review Of The Literature ◽  
Tumour Thrombus ◽  
Image Reversal

Situs inversus, an uncommon mirror-image reversal of the major visceral and thoracic organs, is seldom of medical significance. However, the recognition of their unique anatomy is extremely important for those requiring surgical intervention. There are very few reported cases of renal cell carcinoma (RCC) developing in people with situs inversus. To our knowledge, this is the first reported case in Canada. A review of the literature only identified nine published cases worldwide. Here, we review and summarize pertinent information, including patient age and sex, size and location of tumour, method of surgery, and pathology. Our case, a 65-yearold male, presented with left flank pain and gross hematuria. He was diagnosed with left renal cancer as well as tumour thrombus extending into the left renal veins and inferior vena cava (IVC), clinical T3aN0M0. An abdomen and pelvis computed tomography (CT) scan showed a left-to-right reversal of his organs, a mirrorimage, and situs inversus was diagnosed. A left radical nephrectomy with left renal vein and IVC tumour thrombectomy through a left open midline incision was performed.

scholarly journals Robust response to nivolumab in patient with renal cell carcinoma inferior vena cava tumour thrombus

2019 ◽  
Vol 12 (4) ◽  
pp. e227030 ◽  
Author(s):  
Joel Berends ◽  
Eric Gourley ◽  
Dharam Kaushik
Keyword(s):  
Renal Cell Carcinoma ◽  
Inferior Vena Cava ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Inferior Vena ◽  
Vena Cava ◽  
Distant Metastases ◽  
Molecular Therapy ◽  
Tumour Thrombus ◽  
Robust Response

A 47-year-old previously healthy man presented with acute moderate flank pain. Evaluation revealed left renal cell carcinoma, with inferior vena cava tumour thrombus invasion. Patient had no significant history or risk factors to pre-dispose him to genitourinary cancers. Surgery was deemed to not be appropriate due to distant metastases, but patient received targeted molecular therapy and immunotherapy with striking regression of the thrombus.

Renal cell carcinoma and tumour thrombus in the inferior vena cava: clinical outcome of 98 consecutive patients and the prognostic value of preoperative parameters

2014 ◽  
Vol 33 (10) ◽  
pp. 1541-1552 ◽  
Author(s):  
Christian Niedworok ◽  
Bettina Dörrenhaus ◽  
Frank vom Dorp ◽  
Jarowit Adam Piotrowski ◽  
Stephan Tschirdewahn ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Clinical Outcome ◽  
Inferior Vena Cava ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Prognostic Value ◽  
Inferior Vena ◽  
Vena Cava ◽  
Tumour Thrombus

Surgical Management of Renal Cell Carcinoma (RCC) with Vena Cava Tumour Thrombus

2006 ◽  
Vol 5 (8) ◽  
pp. 610-618 ◽  
Author(s):  
Emanuele Belgrano ◽  
Carlo Trombetta ◽  
Salvatore Siracusano ◽  
Giorgio Carmignani ◽  
Giuseppe Martorana ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Surgical Management ◽  
Renal Cell ◽  
Vena Cava ◽  
Tumour Thrombus

Results of surgical treatment of inferior vena cava tumor thrombi in renal cell carcinoma

2020 ◽  
Vol 99 (4) ◽  
pp. 167-171
Keyword(s):  
Renal Cell Carcinoma ◽  
Surgical Treatment ◽  
Inferior Vena Cava ◽  
Cell Carcinoma ◽  
Kidney Cancer ◽  
Renal Cell ◽  
Inferior Vena ◽  
Vena Cava ◽  
Oncological Treatment ◽  
Tumour Thrombus

Introduction: Thrombosis of inferior vena cava (IVC) is an important complication amongst oncological patients. Tumor thrombus of IVC is characteristic for patients with renal cell carcinoma, occurring in 10−18%. The aim of the work is to analyze of surgical treatment in patients with cancer thrombosis of inferior vena cava in kidney cancer. Methods: Between 2010 and 2019 we treated 32 patients with kidney cancer complicated by thrombotic infiltration of the inferior vena cava. According to Nesbitt classification the levels of thrombotic infiltration of the inferior vena cava were: I–8 (25%), II–14 (43.8%), III–6 (18.8%), and IV–4 (12.5%). Nephrectomy with thrombectomy of the cancer thrombus in the inferior vena cava was performed in all patients. In addition to laparotomy, sternotomy was approached in 4 patients with Nesbitt IV and in 2 patients with Nesbitt III. Results: Primary suture of IVC was performed in 26 patients; angioplasty of IVC was performed in 4 patients; and resection of IVC with replacement using a polytetrafluoroethylene interposition graft was done in 2 patients. Radical surgical treatment was performed in 27 (84.3%) patients, and palliative in 5 (15.6%) patients. In the postoperative period, 1 (3.1%) patient (Nesbitt IV) died of cardiac failure during hospitalisation. Two-year survival was observed in 75% of the cases. Conclusion: Tumorous infiltration of IVC is associated with a high potential for tumour embolisation to the lungs, leading to the formation of multiple metastases and spreading of the underlying disease. Postoperative comfort is improved considerably after nephrectomy of the affected kidney and removal of the tumour thrombus, including IVC resection as appropriate, and when combined with oncological treatment, the survival rate is increased significantly, as well.

Important surgical considerations in the management of renal cell carcinoma (RCC) with inferior vena cava (IVC) tumour thrombus

2012 ◽  
Vol 110 (7) ◽  
pp. 926-939 ◽  
Author(s):  
Samuel M. Lawindy ◽  
Tony Kurian ◽  
Timothy Kim ◽  
Devanand Mangar ◽  
Paul A. Armstrong ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Inferior Vena Cava ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Inferior Vena ◽  
Vena Cava ◽  
Tumour Thrombus
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