Background:
The design and characteristics of alginate biomaterial have a significant role in wound dressing and
tissue regeneration. The ideal biomaterial for wound dressing must have biodegradable, biocompatible, non-inflammatory,
non-toxic.
Objective:
Wound dressing should promote the re-epithelization and protect the wound for further infection by creating a moist
environment. The physical and mechanical nature of the alginate biopolymer has the potential to influence the
pathophysiological mechanisms in the chronic wound actively. The application of this biomaterial provides an ampule
advantage to synthetic polymers.
Method:
The wound healing process is a critical step involved in different phases. The presence of cross-linkers, polymers
along with alginate lead to a decrease in the mechanical property of dressing. Hence the effective material choosing along with
alginate is a very critical decision. The therapeutic efficacy of the alginate dressing system (film, hydrogel, wafer, etc.)
influenced by the incorporation of different materials such as bioactive agents, nanoparticles, cross-linker, nature of the
excipients, etc.
Results:
The ion exchange occurring between dressing and exudates resulted in the formation of gel, due to the glucuronic
acid presence in alginate. This gel absorbs moisture and maintains an appropriate moist environment and actively influence
the pathophysiological mechanisms in the chronic wound.
Conclusion:
This review gives a detailed knowledge of the researchers to work with alginate and provides knowledge about
the incorporation of the appropriate material and their therapeutic efficacy in wound dressing.
BioFibGel: A Green Nanotechnology Based Wound Dressing
