scholarly journals Xanthine Oxidase Inhibition Activity and ADMET Properties of Terap (Artocarpus odoratissimus Blanco) Leaves Metabolites: Phytochemical Screening and in silico Studies

2021 ◽  
Vol 13 (5) ◽  
pp. 1150-1160
Author(s):  
Nisa Naspiah ◽  
Mohammad Rizki Fadhil Pratama ◽  
Sukardiman Sukardiman S
Keyword(s):  
Xanthine Oxidase ◽  
In Silico ◽  
Inhibition Activity ◽  
Phytochemical Screening ◽  
In Silico Studies ◽  
Oxidase Inhibition ◽  
Xanthine Oxidase Inhibition

Preparation of ferulic acid derivatives and evaluation of their xanthine oxidase inhibition activity

2007 ◽  
Vol 21 (3) ◽  
pp. 196-202 ◽  
Author(s):  
Feng Wang ◽  
Leixiang Yang ◽  
Kexin Huang ◽  
Xiaokun Li ◽  
Xiaojiang Hao ◽  
...  
Keyword(s):  
Ferulic Acid ◽  
Xanthine Oxidase ◽  
Inhibition Activity ◽  
Oxidase Inhibition ◽  
Xanthine Oxidase Inhibition

Antioxidant activity and xanthine oxidase inhibition activity of reductic acid: ascorbic acid analogue

2000 ◽  
Vol 10 (24) ◽  
pp. 2783-2785 ◽  
Author(s):  
Tadahiko Mashino ◽  
Yasushi Takigawa ◽  
Naomi Saito ◽  
Liquing Q Wong ◽  
Masataka Mochizuki
Keyword(s):  
Antioxidant Activity ◽  
Ascorbic Acid ◽  
Xanthine Oxidase ◽  
Inhibition Activity ◽  
Acid Analogue ◽  
Oxidase Inhibition ◽  
Xanthine Oxidase Inhibition

Purpurogallin is a more powerful protector of kidney cells than Trolox and allopurinol

1992 ◽  
Vol 70 (8) ◽  
pp. 684-690 ◽  
Author(s):  
Ling-Hua Zeng ◽  
Tai-Wing Wu
Keyword(s):  
Xanthine Oxidase ◽  
Phase Contrast ◽  
Potent Inhibitor ◽  
Rat Kidney ◽  
Peroxyl Radicals ◽  
Kidney Cells ◽  
Tubular Epithelial Cells ◽  
Electron Microscopic ◽  
Oxidase Inhibition ◽  
Xanthine Oxidase Inhibition

Phase contrast and electron microscopic experiments demonstrated that oxyradicals generated with xanthine oxidase and hypoxanthine markedly damage rat kidney mesangial and porcine tubular epithelial cells. Purpurogallin, a phenol found in oak nutgalls, prolongs survival of the xanthine oxidase exposed renal cells three- to nine-fold longer than those without purpurogallin present. At levels equimolar to purpurogallin, either Trolox or allopurinol is less effective in delaying cell necrosis. Purpurogallin scavenges not only xanthine oxidase generated oxyradicals, but also non-enzymatically produced peroxyl radicals, more actively than equimolar levels of Trolox or allopurinol. Purpurogallin inhibits xanthine oxidase with severalfold higher potency than allopurinol and its more active metabolite oxypurinol. Therefore, purpurogallin is a stronger antioxidant than Trolox and a more potent inhibitor of xanthine oxidase than allopurinol as well as oxypurinol.Key words: purpurogallin, kidney cells, oxyradical damage, xanthine oxidase inhibition, antioxidant.

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