scholarly journals Effects of Captopril on the Peripheral Hemodynamics, Platelet Function, Plasma Prostaglandins and Other Blood Parameters in Essential Hypertension

1986 ◽  
Vol 14 (3) ◽  
pp. 653-659 ◽  
Author(s):  
Yuzo NAGAKAWA ◽  
Yoko ONUKI ◽  
Hajime ORIMO ◽  
Michiyoshi HARASAWA
Keyword(s):  
Essential Hypertension ◽  
Platelet Function ◽  
Blood Parameters ◽  
Peripheral Hemodynamics

The Effect of Short-Term Celiprolol Therapy on Platelet Function in Essential Hypertension

Cardiology ◽  
1993 ◽  
Vol 82 (6) ◽  
pp. 399-404 ◽  
Author(s):  
Anna Okrucká ◽  
Jozef Pecháň ◽  
Ivan Balažovjech
Keyword(s):  
Essential Hypertension ◽  
Platelet Function ◽  
Short Term

scholarly journals Plasma Adrenaline: Relations to Blood Pressure, Blood Platelet Function and Blood Lipids in Essential Hypertension

1988 ◽  
Vol 63 ◽  
pp. 35-37
Author(s):  
Sverre E. Kjeldsen ◽  
Knut Lande ◽  
Knut Gjesdal ◽  
Paul Leren ◽  
Ivar K. Eide
Keyword(s):  
Blood Pressure ◽  
Essential Hypertension ◽  
Platelet Function ◽  
Blood Lipids ◽  
Blood Platelet ◽  
Plasma Adrenaline

scholarly journals COVID-19 induces a hyperactive phenotype in circulating platelets

2020 ◽  
Author(s):  
Shane P Comer ◽  
Sarah Cullivan ◽  
Paulina B Szklanna ◽  
Luisa Weiss ◽  
Steven Cullen ◽  
...  
Keyword(s):  
Intensive Care ◽  
Platelet Function ◽  
Clinical Laboratory ◽  
Platelet Reactivity ◽  
Severe Disease ◽  
Blood Parameters ◽  
Full Blood Count ◽  
Specific Marker ◽  
Platelet Activity ◽  
Thrombotic Risk

Background Coronavirus disease 2019 (COVID-19), caused by novel coronavirus SARS-CoV-2, has to date affected over 13.3 million globally. Although high rates of venous thromboembolism and evidence of COVID-19-induced endothelial dysfunction have been reported, the precise aetiology of the increased thrombotic risk associated with COVID-19 infection remains to be fully elucidated. Objectives Here, we assessed clinical platelet parameters and circulating platelet activity in patients with severe and non-severe COVID-19. Methods An assessment of clinical blood parameters in patients with severe COVID-19 disease (requiring intensive care), patients with non-severe disease (not requiring intensive care), general medical in-patients without COVID-19 and healthy donors was undertaken. Platelet function and activity were also assessed by secretion and specific marker analysis. Results We show that routine clinical blood parameters including increased MPV and decreased platelet:neutrophil ratio are associated with disease severity in COVID-19 upon hospitalisation and intensive care unit admission. Strikingly, agonist-induced ADP release was dramatically higher in COVID-19 patients compared with non-COVID-19 hospitalized patients and circulating levels of PF4, sP-selectin and TPO were also significantly elevated in COVID-19. Conclusion Distinct differences exist in routine full blood count and other clinical laboratory parameters between patients with severe and non-severe COVID-19. Moreover, we have determined that COVID-19 patients possess hyperactive circulating platelets. These data suggest that abnormal platelet reactivity may contribute to hypercoagulability in COVID-19. Further investigation of platelet function in COVID-19 may provide additional insights into the aetiology of thrombotic risk in this disease and may contribute to the optimisation of thrombosis prevention and treatment strategies.

Effects of lisinopril and hydrochlorothiazide on platelet function and blood rheology in essential hypertension: a randomly allocated double-blind study

1993 ◽  
Vol 11 (5) ◽  
pp. 559-564 ◽  
Author(s):  
Faiez Zannad ◽  
Laure Bray-Desboscs ◽  
Raghida El Ghawi ◽  
Mireille Donner ◽  
Emmanuel Thibout ◽  
...  
Keyword(s):  
Essential Hypertension ◽  
Platelet Function ◽  
Blood Rheology ◽  
Blind Study ◽  
Double Blind Study ◽  
Double Blind

Increased β-Thromboglobulin in Essential Hypertension: Interactions between Arterial Plasma Adrenaline, Platelet Function and Blood Lipids

2009 ◽  
Vol 213 (5) ◽  
pp. 369-373 ◽  
Author(s):  
Sverre Erik Kjeldsen ◽  
Knut Gjesdal ◽  
Ivar Eide ◽  
Ingvar Aakesson ◽  
Ruth Amundsen ◽  
...  
Keyword(s):  
Essential Hypertension ◽  
Platelet Function ◽  
Blood Lipids ◽  
Plasma Adrenaline ◽  
Arterial Plasma

Hypercholesterolemia Modulates the Effects of Nitrendipine on Blood Pressure and Platelet Function in Essential Hypertension

1991 ◽  
Vol 18 ◽  
pp. S46-S51 ◽  
Author(s):  
M. M. Mazeaud ◽  
K. H. Le Quan Sang ◽  
C. Astarie ◽  
J. Levenson ◽  
A. Simon ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Essential Hypertension ◽  
Platelet Function
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