Increased β-Thromboglobulin in Essential Hypertension: Interactions between Arterial Plasma Adrenaline, Platelet Function and Blood Lipids

2009 ◽  
Vol 213 (5) ◽  
pp. 369-373 ◽  
Author(s):  
Sverre Erik Kjeldsen ◽  
Knut Gjesdal ◽  
Ivar Eide ◽  
Ingvar Aakesson ◽  
Ruth Amundsen ◽  
...  
Keyword(s):  
Essential Hypertension ◽  
Platelet Function ◽  
Blood Lipids ◽  
Plasma Adrenaline ◽  
Arterial Plasma

The Effect of Short-Term Celiprolol Therapy on Platelet Function in Essential Hypertension

Cardiology ◽  
1993 ◽  
Vol 82 (6) ◽  
pp. 399-404 ◽  
Author(s):  
Anna Okrucká ◽  
Jozef Pecháň ◽  
Ivan Balažovjech
Keyword(s):  
Essential Hypertension ◽  
Platelet Function ◽  
Short Term

Effects of lisinopril and hydrochlorothiazide on platelet function and blood rheology in essential hypertension: a randomly allocated double-blind study

1993 ◽  
Vol 11 (5) ◽  
pp. 559-564 ◽  
Author(s):  
Faiez Zannad ◽  
Laure Bray-Desboscs ◽  
Raghida El Ghawi ◽  
Mireille Donner ◽  
Emmanuel Thibout ◽  
...  
Keyword(s):  
Essential Hypertension ◽  
Platelet Function ◽  
Blood Rheology ◽  
Blind Study ◽  
Double Blind Study ◽  
Double Blind

scholarly journals Association of Polymorphisms of Genes Involved in Lipid Metabolism with Blood Pressure and Lipid Values in Mexican Hypertensive Individuals

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Blanca Estela Ríos-González ◽  
Bertha Ibarra-Cortés ◽  
Guadalupe Ramírez-López ◽  
José Sánchez-Corona ◽  
María Teresa Magaña-Torres
Keyword(s):  
Blood Pressure ◽  
Essential Hypertension ◽  
Lipid Metabolism ◽  
Total Cholesterol ◽  
Blood Lipids ◽  
Dominant Model ◽  
Lipid Levels ◽  
Pcr Rflp ◽  
Clinical Relationship ◽  
Lipid Metabolism Genes

Hypertension and dyslipidemia exhibit an important clinical relationship because an increase in blood lipids yields an increase in blood pressure (BP). We analyzed the associations of seven polymorphisms of genes involved in lipid metabolism (APOA5rs3135506,APOBrs1042031,FABP2rs1799883,LDLRrs5925,LIPCrs1800588,LPLrs328, andMTTPrs1800591) with blood pressure and lipid values in Mexican hypertensive (HT) patients. A total of 160 HT patients and 160 normotensive individuals were included. Genotyping was performed through PCR-RFLP, PCR-AIRS, and sequencing. The results showed significant associations in the HT group and HT subgroups classified as normolipemic and hyperlipemic. The allelesFABP2p.55T,LIPC−514T, andMTTP−493T were associated with elevated systolic BP. Five alleles were associated with lipids.LPLp.474X andFABP2p.55T were associated with decreased total cholesterol and LDL-C, respectively;APOA5p.19W with increased HDL-C;APOA5p.19W andFABP2p.55T with increased triglycerides; andAPOBp.4181K andLDLRc.1959T with decreased triglycerides. TheAPOBp.E4181K polymorphism increases the risk for HT (OR = 1.85, 95% CI: 1.17–2.93;P=0.001) under the dominant model. These findings indicate that polymorphisms of lipid metabolism genes modify systolic BP and lipid levels and may be important in the development of essential hypertension and dyslipidemia in Mexican HT patients.

scholarly journals Arterial plasma norepinephrine correlates to blood pressure in middle-aged men with sustained essential hypertension

1989 ◽  
Vol 118 (4) ◽  
pp. 775-781 ◽  
Author(s):  
Sverre E. Kjeldsen ◽  
Nicholas J. Schork ◽  
Paul Leren ◽  
Ivar K. Eide
Keyword(s):  
Blood Pressure ◽  
Essential Hypertension ◽  
Plasma Norepinephrine ◽  
Middle Aged ◽  
Arterial Plasma

Effects of Adrenaline Infusion on Platelet Number, Volume and Release Reaction

1985 ◽  
Vol 54 (02) ◽  
pp. 450-453 ◽  
Author(s):  
K Lande ◽  
K Gjesdal ◽  
E Fønstelien ◽  
S E Kjeldsen ◽  
I Eide
Keyword(s):  
Femoral Vein ◽  
Blood Platelet ◽  
Right Heart Catheterization ◽  
Heart Catheterization ◽  
Platelet Volume ◽  
Plasma Adrenaline ◽  
Platelet Number ◽  
Adrenaline Infusion ◽  
Arterial Plasma ◽  
Physiological Values

SummaryAt the end of a diagnostic right heart catheterization ten patients received an intravenous infusion of l-adrenaline which gradually increased the arterial plasma adrenaline concentration from resting physiological values to high values as seen during myocardial infarction, pheochromocytoma and hypoglycemia. Blood was sampled from the brachial artery, femoral vein and hepatic vein. During the adrenaline infusion venous beta-thromboglobulin concentrations increased 23% from 61 ± 5 to 80 ± 7 μg/l (mean ± SE), arterial platelet counts 20% from 212 ± 17 to 253 ± 25 × 109/l and arterial platelet volume 4% from 7.25 ± 0.20 to 7.56 ± 0.21 femtoliter. All changes were significant at the 5% level. Thus, acute increments of arterial plasma adrenaline significantly stimulated the blood platelet parameters studied.

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