scholarly journals Plasma Adrenaline: Relations to Blood Pressure, Blood Platelet Function and Blood Lipids in Essential Hypertension

1988 ◽  
Vol 63 ◽  
pp. 35-37
Author(s):  
Sverre E. Kjeldsen ◽  
Knut Lande ◽  
Knut Gjesdal ◽  
Paul Leren ◽  
Ivar K. Eide
Keyword(s):  
Blood Pressure ◽  
Essential Hypertension ◽  
Platelet Function ◽  
Blood Lipids ◽  
Blood Platelet ◽  
Plasma Adrenaline

Increased β-Thromboglobulin in Essential Hypertension: Interactions between Arterial Plasma Adrenaline, Platelet Function and Blood Lipids

2009 ◽  
Vol 213 (5) ◽  
pp. 369-373 ◽  
Author(s):  
Sverre Erik Kjeldsen ◽  
Knut Gjesdal ◽  
Ivar Eide ◽  
Ingvar Aakesson ◽  
Ruth Amundsen ◽  
...  
Keyword(s):  
Essential Hypertension ◽  
Platelet Function ◽  
Blood Lipids ◽  
Plasma Adrenaline ◽  
Arterial Plasma

scholarly journals Association of Polymorphisms of Genes Involved in Lipid Metabolism with Blood Pressure and Lipid Values in Mexican Hypertensive Individuals

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Blanca Estela Ríos-González ◽  
Bertha Ibarra-Cortés ◽  
Guadalupe Ramírez-López ◽  
José Sánchez-Corona ◽  
María Teresa Magaña-Torres
Keyword(s):  
Blood Pressure ◽  
Essential Hypertension ◽  
Lipid Metabolism ◽  
Total Cholesterol ◽  
Blood Lipids ◽  
Dominant Model ◽  
Lipid Levels ◽  
Pcr Rflp ◽  
Clinical Relationship ◽  
Lipid Metabolism Genes

Hypertension and dyslipidemia exhibit an important clinical relationship because an increase in blood lipids yields an increase in blood pressure (BP). We analyzed the associations of seven polymorphisms of genes involved in lipid metabolism (APOA5rs3135506,APOBrs1042031,FABP2rs1799883,LDLRrs5925,LIPCrs1800588,LPLrs328, andMTTPrs1800591) with blood pressure and lipid values in Mexican hypertensive (HT) patients. A total of 160 HT patients and 160 normotensive individuals were included. Genotyping was performed through PCR-RFLP, PCR-AIRS, and sequencing. The results showed significant associations in the HT group and HT subgroups classified as normolipemic and hyperlipemic. The allelesFABP2p.55T,LIPC−514T, andMTTP−493T were associated with elevated systolic BP. Five alleles were associated with lipids.LPLp.474X andFABP2p.55T were associated with decreased total cholesterol and LDL-C, respectively;APOA5p.19W with increased HDL-C;APOA5p.19W andFABP2p.55T with increased triglycerides; andAPOBp.4181K andLDLRc.1959T with decreased triglycerides. TheAPOBp.E4181K polymorphism increases the risk for HT (OR = 1.85, 95% CI: 1.17–2.93;P=0.001) under the dominant model. These findings indicate that polymorphisms of lipid metabolism genes modify systolic BP and lipid levels and may be important in the development of essential hypertension and dyslipidemia in Mexican HT patients.

Elevated Plasma Adrenaline Reflects Sympathetic Overactivity and Enhanced α-Adrenoceptor-Mediated Vasoconstriction in Essential Hypertension

1981 ◽  
Vol 61 (s7) ◽  
pp. 161s-164s ◽  
Author(s):  
P. Bolli ◽  
F. W. Amann ◽  
L. Hulthén ◽  
W. Kiowski ◽  
F. R. Bühler
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Blood Flow ◽  
Essential Hypertension ◽  
Forearm Blood Flow ◽  
Cold Pressor Test ◽  
Cold Pressor ◽  
Plasma Adrenaline ◽  
Pressor Test ◽  
Normotensive Subjects

1. Stressful sympathetic stimulation (cold pressor test) was applied to 18 patients with essential hypertension and 15 normotensive subjects. Intra-arterial blood pressure, heart rate, plasma adrenaline and noradrenaline concentrations as well as forearm blood flow were measured before and during the cold pressor test; tests were repeated after regional postsynaptic α1-adrenoceptor blockade with prazosin. 2. Under basal conditions mean blood pressure (P < 0.001), heart rate (P < 0.01), forearm blood flow (P < 0.001) as well as adrenaline concentration (P < 0.01), but not noradrenaline, was higher in patients with essential hypertension. 3. During the cold pressor test, mean blood pressure, heart rate, plasma adrenaline and noradrenaline concentrations increased and forearm flow decreased (all P < 0.001). 4. Stress-stimulated plasma adrenaline was higher in essential hypertensive patients than in normotensive subjects (P < 0.01). In the former the stress-induced increase in plasma adrenaline correlated with the increase in mean blood pressure (r = 0.514; P < 0.05). 5. Prazosin increased forearm blood flow more in essential hypertension (P < 0.001). This increase correlated with the resting plasma adrenaline in the hypertensive (r = 0.710; P < 0.001), but not in normotensive, subjects. 6. When the cold pressor test was repeated during postsynaptic α1-adrenoceptor blockade forearm blood flow did not decrease; instead it increased further in both groups (P < 0.05). 7. Thus in essential hypertension elevated plasma adrenaline concentration reflects sympathetic overactivity as also expressed by enhanced α-adrenoceptor-mediated vasoconstriction.

Hypercholesterolemia Modulates the Effects of Nitrendipine on Blood Pressure and Platelet Function in Essential Hypertension

1991 ◽  
Vol 18 ◽  
pp. S46-S51 ◽  
Author(s):  
M. M. Mazeaud ◽  
K. H. Le Quan Sang ◽  
C. Astarie ◽  
J. Levenson ◽  
A. Simon ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Essential Hypertension ◽  
Platelet Function

Hypercholesterolemia Modulates the Effects of Nitrendipine on Blood Pressure and Platelet Function in Essential Hypertension

1991 ◽  
Vol 18 ◽  
pp. S46-S51
Author(s):  
M. M. Mazeaud ◽  
K. H. Le Quan Sang ◽  
C. Astarie ◽  
J. Levenson ◽  
A. Simon ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Essential Hypertension ◽  
Platelet Function

Does Increased Platelet Release Normalize During Anti-Hypertensive Treatment?

1987 ◽  
Vol 58 (03) ◽  
pp. 834-838
Author(s):  
Knut Lande ◽  
Sverre Erik Kjeldsen ◽  
Ivar Eide ◽  
Paul Leren ◽  
Knut Gjesdal
Keyword(s):  
Platelet Function ◽  
Adrenergic Receptor ◽  
Blood Platelet ◽  
Placebo Treatment ◽  
Sampling Procedure ◽  
Β Blocker ◽  
Platelet Release ◽  
Hypertensive Drug ◽  
Second Period ◽  
Release Product

SummaryBlood platelet function was evaluated in 10 men, all 50 years old, with untreated, mild hypertension. Each patient was examined four times: At the beginning of the study, after 5 weeks on placebo treatment, after the following 5 weeks on propranolol 160 mg daily, and finally after a second period of 5 weeks on placebo. At baseline the plasma level of the platelet release product (β-thromboglobulin (BTG) was 41.6 (30.5-57.0) μg/l (median and 95% confidence interval). During the first placebo period BTG was normalized to 21.0 (14.1-25.9) μg/l. While systolic blood pressure and heart rate fell during β-adrenergic receptor blockade, BTG remained unchanged throughout the rest of the observation periods. Platelet size increased significantly during treatment with β-blocker. The present study indicates that the normalization of elevated platelet function which previously has been reported to occur during anti-hypertensive drug therapy, may be explained by patient adaptation to the blood sampling procedure.

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