Celiac disease in patients with type-1 diabetes mellitus screened by tissue transglutaminase antibodies in southern Kerala, India

10.5580/10cc ◽  
2009 ◽  
Vol 8 (2) ◽  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Celiac Disease ◽  
Type 1 Diabetes Mellitus ◽  
Tissue Transglutaminase ◽  
Tissue Transglutaminase Antibodies

scholarly journals The Positivity of Anti-TPO and Anti-tTGA in Children with Type 1 Diabetes Mellitus in Albania

2022 ◽  
Vol 12 (1) ◽  
pp. 157-160
Author(s):  
Margarita Kurti
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Celiac Disease ◽  
Type 1 Diabetes Mellitus ◽  
Autoimmune Thyroid Disease ◽  
Tissue Transglutaminase ◽  
Control Group ◽  
Thyroid Peroxidase ◽  
Autoimmune Thyroid

Background: Type 1 diabetes mellitus (T1 DM) is the most common type of diabetes in children. T1DM patients are also at higher risk of other comorbid autoimmune diseases, including autoimmune thyroid disease (AITD), celiac disease (CD). The thyroid-specific immune damage of AITD is strongly associated with elevated serum thyroid peroxidase (TPO). Tissue transglutaminase antibody (tTGA) is a specific antibody and a serological marker of CD. This study aimed to evaluate the positivity of anti - TPO and anti - tTGA in children with T1DM after they were diagnosed. Materials and Methods: This study was conducted from January 2019 to October 2020, included 105 children with T1DM. 44 children matching in aged (1 - 14 years) and gender were taken as control with other diagnoses (16 with viral infection, 24 with short stature, 4 with genetic disorders). The antibodies were checked up for the first time after they were diagnosed. Anti - TPO and anti - tTGA were carried out by ELISA. Results: 55.2% of T1DM children were girls. The anti-TPO was positive in 30.5% of T1DM children compared to 4.5% of children in control group. The anti-tTGA was positive in 7.6% of T1DM children compared to 2.3% of children in control group. Risk of Hashimoto's hypothyroidism was more in children older than 10 years old. 21.9% of children 11 - 14 years old were anti - TPO positive, but it was 16.2%, more common in girls. While, anti - tTGA was positive in 3.85% of children 1 - 5 years old with no difference between boys and girls. Conclusion The most frequent autoimmune disease resulted Hashimoto's hypothyroidism. Girls with T1DM have a higher predisposition to Hashimoto's Hypothyroidism in the 11-14 age group compared to boys. Children with T1DM were found to have a lower predisposition to CD. Children with T1DM have a higher predisposition to develop CD at the age of 1 - 5 years. In conclusion we can say that antibodies to other autoimmune diseases must be performed together with diagnostic examinations for T1DM. Key words: Type 1 diabetes mellitus, Autoimmune Thyroid Disease, Celiac Disease, Thyroid Peroxidase, Tissue Transglutaminase Antibody.

Increased prevalence of disordered eating in the dual diagnosis of type 1 diabetes mellitus and celiac disease

2019 ◽  
Author(s):  
Tokatly Latzer I ◽  
Rachmiel M ◽  
Zuckerman Levin N ◽  
Mazor-Aronovitch K ◽  
Landau Z ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Celiac Disease ◽  
Type 1 Diabetes Mellitus ◽  
Disordered Eating ◽  
Dual Diagnosis

The prevalence, immune profile, and clinical characteristics of children with celiac disease and type 1 diabetes mellitus in the state of Qatar

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Basma Haris ◽  
Ahmed Abdellatief ◽  
Houda Afyouni ◽  
Tasneem Abdel-Karim ◽  
Shayma Mohammed ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Celiac Disease ◽  
Type 1 Diabetes Mellitus ◽  
Clinical Characteristics ◽  
Family History Of Diabetes ◽  
Positive Type ◽  
Immune Profile ◽  
Insulin Autoantibody

Abstract Objectives Children with antibody positive type 1 diabetes mellitus (type 1 diabetes) are at an increased risk of developing celiac disease (CD) which suggests a common autoimmune basis with both high-risk human lymphocyte antigen (HLA) and non-HLA factors playing a role in the pathophysiology. We aim to describe the prevalence, immune profile, and clinical characteristics of children with CD who have type 1 diabetes mellitus in Qatar. Methods All children (aged 0–18 years) attending a regional diabetes clinic with antibody positive type 1 diabetes were screened for CD. Measurement of tissue transglutaminase IgA and IgG as well as anti-endomysial antibody, was done, clinical details about the birth history, family history of diabetes and CD, age of onset, and ethnicity were collected. Results Out of the 1,325 children with antibody positive type 1 diabetes, 54 were identified to have CD on screening and then confirmed on small bowel biopsy. The prevalence of CD in the type 1 diabetes childhood population in Qatar is 4.07%. CD and type 1 diabetes were more prevalent in the Qatari children (n=32) as compared to non-Qatari (n=22) and occurred mostly in the age group 6–10 years. The most common type 1 diabetes antibodies in children with CD were glutamic acid decarboxylase and insulin autoantibody. Twelve subjects were asymptomatic for CD symptoms and picked up only on screening. Conclusions The prevalence of CD in children with type 1 diabetes in Qatar is comparable to reports from around the world. Many children were asymptomatic and thus routine screening is recommended.

Type 1 Diabetes Mellitus, Celiac Disease and NASH-Related Cirrhosis in a 3-Year-Old Boy with Acquired Generalized Lipodystrophy

2011 ◽  
pp. P3-746-P3-746
Author(s):  
Monica Grover ◽  
Andrea Erika Balazs ◽  
Carlos A Bacino ◽  
Christian Patrick Schaaf ◽  
Saul J Karpen ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Celiac Disease ◽  
Type 1 Diabetes Mellitus

Increased prevalence of disordered eating in the dual diagnosis of type 1 diabetes mellitus and celiac disease

2018 ◽  
Vol 19 (4) ◽  
pp. 749-755 ◽  
Author(s):  
Itay Tokatly Latzer ◽  
Marianna Rachmiel ◽  
Nehama Zuckerman Levin ◽  
Kineret Mazor-Aronovitch ◽  
Zohar Landau ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Celiac Disease ◽  
Type 1 Diabetes Mellitus ◽  
Disordered Eating ◽  
Dual Diagnosis

AACE2021-A-1074: Occurrence of Celiac Disease and Socio-Demographic Parameters in Type-1 Diabetes Mellitus

2021 ◽  
Vol 27 (12) ◽  
pp. S38
Author(s):  
Paras Imran ◽  
Saeeda Fouzia Qasim ◽  
Saba Latif ◽  
Mohammad Yahya ◽  
Saima Athar Shaikh
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Celiac Disease ◽  
Type 1 Diabetes Mellitus ◽  
Demographic Parameters

scholarly journals Prevalence of Celiac Disease in Omani Children with Type 1 Diabetes Mellitus: A Cross Sectional Study

2013 ◽  
Vol 28 (4) ◽  
pp. 260-263 ◽  
Author(s):  
Siham Al-Sinani ◽  
Sharef Waadallah Sharef ◽  
Saif Al-Yaarubi ◽  
Ibrahim Al-Zakwani ◽  
Khalid Al-Naamani ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Celiac Disease ◽  
Type 1 Diabetes Mellitus ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional

scholarly journals Interplay between Type 1 Diabetes Mellitus and Celiac Disease: Implications in Treatment

2018 ◽  
Vol 36 (6) ◽  
pp. 399-408 ◽  
Author(s):  
Navchetan Kaur ◽  
Sanjay K. Bhadada ◽  
Ranjana W. Minz ◽  
Devi Dayal ◽  
Rakesh Kochhar
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Celiac Disease ◽  
Type 1 Diabetes Mellitus ◽  
Prevalence Rate ◽  
Vascular Complications ◽  
Complex Situation ◽  
Disease Etiology ◽  
Organ Specific

Background: A complex interplay between genetic and environmental factors contributes to disease etiology of most of the autoimmune disorders. Type 1 diabetes mellitus (T1DM) and celiac disease (CD) are polygenic autoimmune diseases that have high propensity to coexist due to shared etiological factors like genetics and clinico-pathological overlaps. Summary: The mean prevalence rate for coexistence of these diseases is 8%, and this value is a gross underestimation as reported from biopsy-proven symptomatic cases. The prevalence rate will rise when studies will excavate bottom layers of the “celiac iceberg” to detect potential and silent celiac cases. The concomitant presence of both these disorders is a complex situation immunologically as well as clinically. There is an accentuated breakdown of tolerance and proinflammatory cytokine storm that leads to the progression of organ-specific autoimmunity to systemic. No immunomodulating drugs are advocated as exogenous insulin supplementation and gluten exclusion are recommended for T1DM and CD respectively. Nevertheless, these pose certain challenges to both the clinicians and the patients, as gluten free diet (GFD) has been described to have an impact on glycemic control, bone health, and vascular complications. Also intermittent gluten intake by these patients due to non-compliance with GFD also stimulates the autoreactive immune cells that result in an augmented immune response. Key Messages: Large public health studies are needed to estimate the prevalence of all forms of CD in T1DM patients. Strict global guidelines need to be formulated for the disease management and prognosis, and there is also a need for an extensive research on each front to thoroughly understand the co-occurrence of these diseases.

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