scholarly journals Long-Term Changes in Neurocognition and Behavior Following Treatment of Sleep Disordered Breathing in School-Aged Children

SLEEP ◽  
2014 ◽  
Vol 37 (1) ◽  
pp. 77-84 ◽  
Author(s):  
Sarah N. Biggs ◽  
Anna Vlahandonis ◽  
Vicki Anderson ◽  
Robert Bourke ◽  
Gillian M. Nixon ◽  
...  
2014 ◽  
Vol 15 (1) ◽  
pp. 76-82 ◽  
Author(s):  
Anna Vlahandonis ◽  
Stephanie R. Yiallourou ◽  
Scott A. Sands ◽  
Gillian M. Nixon ◽  
Margot J. Davey ◽  
...  

2014 ◽  
Vol 15 (1) ◽  
pp. 83-90 ◽  
Author(s):  
Anna Vlahandonis ◽  
Stephanie R. Yiallourou ◽  
Scott A. Sands ◽  
Gillian M. Nixon ◽  
Margot J. Davey ◽  
...  

2020 ◽  
Vol 9 (6) ◽  
pp. 1739
Author(s):  
Francesca Mallamaci ◽  
Rocco Tripepi ◽  
Graziella D’Arrigo ◽  
Gaetana Porto ◽  
Maria Carmela Versace ◽  
...  

Sleep disordered breathing (SDB), as defined by the Apnea Hypopnea Index (AHI), is a highly prevalent disturbance in end stage kidney disease. SDB improves early on after renal transplantation but long-term changes in AHI in these patients have not been studied. We studied the long-term changes in AHI in a series of 221 renal transplant patients (mean age: 47 ± 12 years; 70% males) over a median follow up of 35 months. Data analysis was made by the generalized estimating equations method (GEE). On longitudinal observation, the median AHI rose from 1.8 (Interquartile range: 0.6–5.0) to 2.9 (IQR: 1.0–6.6) and to 3.6 (IQR: 1.7–10.4) at the second and third visit, respectively (p = 0.009 by the GEE model and the proportion of patients with moderate to severe SDB rose from 8% to 20%. Longitudinal changes in minimum oxygen saturation (minSaO2) mirrored those in the AHI. In adjusted analyses, repeated measurements of BMI (p < 0.009) emerged as the strongest independent longitudinal correlate of AHI and MinSaO2. The AHI worsens over time in renal transplant patients and longitudinal changes of this biomarker are directly related to simultaneous changes in BMI. Overweight/obesity, a potentially modifiable risk factor, is an important factor underlying the risk of SDB in this population.


Author(s):  
Juliana Alves Sousa Caixeta ◽  
Jessica Caixeta Silva Sampaio ◽  
Vanessa Vaz Costa ◽  
Isadora Milhomem Bruno da Silveira ◽  
Carolina Ribeiro Fernandes de Oliveira ◽  
...  

Abstract Introduction Adenotonsillectomy is the first-line treatment for obstructive sleep apnea secondary to adenotonsillar hypertrophy in children. The physical benefits of this surgery are well known as well as its impact on the quality of life (QoL), mainly according to short-term evaluations. However, the long-term effects of this surgery are still unclear. Objective To evaluate the long-term impact of adenotonsillectomy on the QoL of children with sleep-disordered breathing (SDB). Method This was a prospective non-controlled study. Children between 3 and 13 years of age with symptoms of SDB for whom adenotonsillectomy had been indicated were included. Children with comorbities were excluded. Quality of life was evaluated using the obstructive sleep apnea questionnaire (OSA-18), which was completed prior to, 10 days, 6 months, 12 months and, at least, 18 months after the procedure. For statistical analysis, p-values lower than 0.05 were defined as statistically significant. Results A total of 31 patients were enrolled in the study. The average age was 5.2 years, and 16 patients were male. The OSA-18 scores improved after the procedure in all domains, and this result was maintained until the last evaluation, done 22 ± 3 months after the procedure. Improvement in each domain was not superior to achieved in other domains. No correlation was found between tonsil or adenoid size and OSA-18 scores. Conclusion This is the largest prospective study that evaluated the long-term effects of the surgery on the QoL of children with SDB using the OSA-18. Our results show adenotonsillectomy has a positive impact in children's QoL.


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