scholarly journals [123I]-Ioflupane SPECT in combination with MIBG myocardial scintigraphy in Parkinson’s disease: a case series study

2016 ◽  
Vol 56 (6) ◽  
pp. 400-406 ◽  
Author(s):  
Akane Yamada ◽  
Takenobu Murakami ◽  
Yongjin Kang ◽  
Yoichiro Iikuni ◽  
Akeshi Morimatsu ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Case Series ◽  
Myocardial Scintigraphy ◽  
Case Series Study ◽  
Series Study

scholarly journals Impact of Footwear and Foot Deformities in patients with Parkinson's disease: A Case-Series Study

2021 ◽  
Vol 18 (2) ◽  
pp. 372-377
Author(s):  
Eloy Trillo Novo ◽  
Daniel López López ◽  
Carmen de Labra Pinedo ◽  
Marta Elena Losa Iglesias ◽  
Ricardo Becerro de Bengoa Vallejo ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Case Series ◽  
Foot Deformities ◽  
Case Series Study ◽  
Series Study

scholarly journals Transplantation of Human Neural Progenitor Cells (NPC) into Putamina of Parkinsonian Patients: A Case Series Study, Safety and Efficacy Four Years after Surgery

2018 ◽  
Vol 28 (3) ◽  
pp. 269-285 ◽  
Author(s):  
I. Madrazo ◽  
O. Kopyov ◽  
M. A. Ávila-Rodríguez ◽  
F. Ostrosky ◽  
H. Carrasco ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Adverse Effects ◽  
Progenitor Cells ◽  
Neural Progenitor Cells ◽  
Case Series ◽  
Neural Progenitor ◽  
Case Series Study ◽  
Human Neural Progenitor Cells ◽  
Series Study

Individuals with Parkinson’s disease (PD) suffer from motor and mental disturbances due to degeneration of dopaminergic and non-dopaminergic neuronal systems. Although they provide temporary symptom relief, current treatments fail to control motor and non-motor alterations or to arrest disease progression. Aiming to explore safety and possible motor and neuropsychological benefits of a novel strategy to improve the PD condition, a case series study was designed for brain grafting of human neural progenitor cells (NPCs) to a group of eight patients with moderate PD. A NPC line, expressing Oct-4 and Sox-2, was manufactured and characterized. Using stereotactic surgery, NPC suspensions were bilaterally injected into patients’ dorsal putamina. Cyclosporine A was given for 10 days prior to surgery and continued for 1 month thereafter. Neurological, neuropsychological, and brain imaging evaluations were performed pre-operatively, 1, 2, and 4 years post-surgery. Seven of eight patients have completed 4-year follow-up. The procedure proved to be safe, with no immune responses against the transplant, and no adverse effects. One year after cell grafting, all but one of the seven patients completing the study showed various degrees of motor improvement, and five of them showed better response to medication. PET imaging showed a trend toward enhanced midbrain dopaminergic activity. By their 4-year evaluation, improvements somewhat decreased but remained better than at baseline. Neuropsychological changes were minor, if at all. The intervention appears to be safe. At 4 years post-transplantation we report that undifferentiated NPCs can be delivered safely by stereotaxis to both putamina of patients with PD without causing adverse effects. In 6/7 patients in OFF condition improvement in UPDRS III was observed. PET functional scans suggest enhanced putaminal dopaminergic neurotransmission that could correlate with improved motor function, and better response to L-DOPA. Patients’ neuropsychological scores were unaffected by grafting. Trial Registration: Fetal derived stem cells for Parkinson’s disease https://doi.org/10.1186/ISRCTN39104513Reg#ISRCTN39104513

Neurophysiological evidence of motor imagery training in Parkinson’s disease: a case series study

2021 ◽  
pp. 1-10
Author(s):  
Kathryn J. M. Lambert ◽  
Anthony Singhal ◽  
Ada W. S. Leung
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Motor Learning ◽  
Motor Imagery ◽  
Case Series ◽  
Mu Rhythm ◽  
Mu Suppression ◽  
Case Series Study ◽  
Series Study ◽  
Training Protocol

Abstract Background: Motor imagery (MI) has become an increasingly popular rehabilitation tool for individuals with motor impairments. However, it has been proposed that individuals with Parkinson’s Disease (PKD) may not benefit from MI due to impairments in motor learning. Objective: This case series study investigated the effects of a 4-week MI training protocol on MI ability in three male individuals with PKD, with an emphasis on examining changes in brain responses. Methods: Training was completed primarily at home, via audio recordings, and emphasized the imagination of functional tasks. MI ability was assessed pre and post-training using subjective and objective imagery questionnaires, alongside an electroencephalographic (EEG) recording of a functional MI task. EEG analysis focused on the mu rhythm, as it has been proposed that suppression in the mu rhythm may reflect MI success and motor learning. Previous research has indicated that mu suppression is impaired in individuals with PKD, and may contribute to the disease’s associated deficits in motor learning. Results: Following training, all three participants improved in MI accuracy, but reported no notable improvements in MI vividness. Greater suppression in the mu rhythm was also exhibited by all three participants post-training. Conclusion: These results suggest the participants learned from the training protocol and that individuals with PKD are responsive to MI training. Further research on a larger scale is needed to verify the findings and determine if this learning translates to improvements in motor function.

Evaluating Vitality and Periodontal Sensitivity of Teeth Adjacent to the Site of Open Sinus Lift Surgery before and after Treatment: A Case Series Study

2020 ◽  
Vol 30 (2) ◽  
pp. 77-81
Author(s):  
Amir Moeintaghavi ◽  
Negar Azami ◽  
Mohammad Sadegh Zohrevand ◽  
Farid Shiezadeh ◽  
Hamid Jafarzadeh ◽  
...  
Keyword(s):  
Case Series ◽  
Sinus Lift ◽  
Case Series Study ◽  
Before And After ◽  
Series Study

Perfil microbiológico en los pacientes con diagnóstico de sinusitis nosocomial hospitalizados en la Unidad de Cuidados Intensivos del Hospital de San José durante el período de Febrero de 2013 a Marzo de 2015. Microbiological profile in patients diagnosed with nosocomial sinusitis hospitalized in the Intensive Care Unit of the Hospital of San Jose during the period February 2013 to March 2015.

2018 ◽  
Vol 45 (4) ◽  
pp. 261-266
Author(s):  
Jorge Luis Alfredo Herrera Ariza ◽  
Mario Alejandro Villabón ◽  
Ángela Carolina Rojas Ruiz ◽  
Iván Fernando Moncada
Keyword(s):  
Disease Control ◽  
Maxillary Sinus ◽  
Case Series ◽  
San Jose ◽  
Study Materials ◽  
Case Series Study ◽  
Nosocomial Sinusitis ◽  
Centers For Disease Control ◽  
Microbial Agents ◽  
Series Study

Objetivo: Determinar los agentes microbianos más frecuentes en pacientes de UCI con diagnóstico de sinusitis nosocomial en el Hospital de San José, período de dos años. Diseño: Estudio observacional tipo serie de casos. Materiales y métodos: Se incluyeron pacientes mayores de 18 años con una estancia hospitalaria mayor a 48 horas, que desarrollaron sinusitis nosocomial de acuerdo a los criterios de los Centers for Disease Control (CDC). Uso de dos técnicas: punción y lavado de seno maxilar. Resultados: 19 pacientes que cumplen los criterios de sinusitis nosocomial. Edad promedio 55 años, predominio sexo masculino. El 94.7% tuvo sonda orogástrica, 89.5% intubación orotraqueal y 89.5% ventilación mecánica. Hubo aislamiento polimicrobiano de gram positivos, gram negativos, anaerobios y hongos. La mortalidad en UCI fue 32%. Conclusiones: Se presenta una adecuada sensibilidad al tratamiento con vancomicina y piperacilina tazobactam en esta patología. El rendimiento diagnóstico es igual al realizar lavado y punción del seno maxilar.Objetive: To determine the microbial agents on UCI patients who have beendiagnosed with nosocomial sinusitis at the San Jose Hospital, (Bogota, Colombia) in a two-year period. Design: Case series study. Materials and methods: Patients who were older than 18-year olds, with a hospitalization longer than 48 hours who developed nosocomial sinusitis, according to the criteria established by the Centers for Disease Control (CDC) were included. Two techniques were employed for data collection: puncture and maxillary sinus wash. Results: 19 patients fulfill the criteria requirements for nosocomial sinusitis. Average age was 55 years old. Population mostly was composed by male individuals. 94.7% had a gastric tube intervention; 89.5% had tracheal intubation 89.5% mechanical ventilation. Polymicrobial isolation with gram positive, gram negative, anaerobic and fungi were identified. Mortality in critical care unites was 32%. Conclusions: An adequate sensitivity to treatment with vancomycin and piperacillin tazobactam was evidenced in this pathology.To perform a washing or maxillary sinus puncture had the same efficiency fordiagnosing this disease.

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