Drug‐induced liver injury caused by herbal and dietary supplements: where to next?

2021 ◽  
Author(s):  
Elliot Freeman ◽  
Stuart K Roberts
Keyword(s):  
Liver Injury ◽  
Dietary Supplements ◽  
Drug Induced ◽  
Drug Induced Liver Injury

scholarly journals Drug-induced Liver Injury Due to a Horse Chestnut Dietary Supplement

2021 ◽  
Author(s):  
Diogo Costa Santos ◽  
Graça Lérias ◽  
Isabel Madruga
Keyword(s):  
Liver Injury ◽  
Dietary Supplements ◽  
Venous Insufficiency ◽  
Acute Liver Injury ◽  
Western World ◽  
Horse Chestnut ◽  
Drug Induced ◽  
Common Cause ◽  
Drug Induced Liver Injury ◽  
Clinically Significant

Drug-induced liver injury (DILI) is the most common cause of acute liver failure in the Western world. In recent years, natural herbal and dietary supplements have become widely available to the general public and have increased in popularity. Reports of idiosyncratic liver injury caused by such supplements have also increased over the last decade. Horse chestnut is a herb used in dietary supplements primarily for complications of venous insufficiency. Clinically significant acute liver injury has been very rarely associated with its use. We present the case of a 70-year-old man with idiosyncratic horse chestnut-induced liver injury.

Monocyte-Derived Hepatocyte-Like Cell Test: A Novel Tool for in vitro Identification of Drug-Induced Liver Injury in Patients with Herbal or Dietary Supplements

Digestion ◽  
2020 ◽  
pp. 1-4
Author(s):  
Sabine Weber ◽  
Grace L.H. Wong ◽  
Vincent W.S. Wong ◽  
Andreas Benesic ◽  
Henry L.Y. Chan ◽  
...  
Keyword(s):  
Liver Injury ◽  
Dietary Supplements ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Cell Test

Drug-induced Liver Injury Secondary to Herbal and Dietary Supplements

2020 ◽  
Vol 24 (1) ◽  
pp. 141-155 ◽  
Author(s):  
Elizabeth Zheng ◽  
Naemat Sandhu ◽  
Victor Navarro
Keyword(s):  
Liver Injury ◽  
Dietary Supplements ◽  
Drug Induced ◽  
Drug Induced Liver Injury

scholarly journals Drug induced liver damage in a universitary hospital

2019 ◽  
Vol 18 (2) ◽  
pp. 201
Author(s):  
Mariana Porto Magalhaes ◽  
Raymundo Paraná ◽  
Genário Oliveira Santos Junior ◽  
Caio Gomes dos Santos Araújo ◽  
Vinicius Santos Nunes ◽  
...  
Keyword(s):  
Liver Injury ◽  
Dietary Supplements ◽  
International Organizations ◽  
Wide Spectrum ◽  
University Hospital ◽  
Medical Sciences ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Central Nervous System Drugs ◽  
Injury Causes

<strong>Background:</strong> Drug Induced Liver Injury (DILI) is responsible for wide spectrum of liver injury. Clinically, these events are presented in various forms and for reaching a different diagnosis other injury causes must be excluded. <strong>Aim:</strong> Identify and characterize cases of hepatotoxicity induced by drugs, herbal and dietary supplements in University Hospital in Brazil. <strong>Material and Methods: </strong>Observational and retrospective study. Was collected in records of University Hospital, between August 2009 at August 2014. The causality of the drug reactions suspected were evaluated Council for International Organizations of Medical Sciences (CIOMS). <strong>Results:</strong> We selected 30 suspected cases, 50% was female and average was 39 years. The therapeutic classes most common was: anti-infectives; antineoplastic agents; central nervous system drugs, anabolic steroid and herbal and dietary supplements (HDS). Cholestatic or mixed injury was observed in 73% these cases; 60% were highly probable, according to CIOMS.  <strong>Conclusion:</strong> DILI is caused by a wide variety of drugs, dietary supplements and dietary supplements. Anti-infectives and chemotherapy were responsible for much of the response

scholarly journals Liver injury from herbals and dietary supplements in the U.S. Drug-Induced Liver Injury Network

Hepatology ◽  
2014 ◽  
Vol 60 (4) ◽  
pp. 1399-1408 ◽  
Author(s):  
Victor J. Navarro ◽  
Huiman Barnhart ◽  
Herbert L. Bonkovsky ◽  
Timothy Davern ◽  
Robert J. Fontana ◽  
...  
Keyword(s):  
Liver Injury ◽  
Dietary Supplements ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
The U.S

Leberschaden unter oraler Antikoagulation, Statin- und ACE-Hemmertherapie

Praxis ◽  
2010 ◽  
Vol 99 (21) ◽  
pp. 1259-1265 ◽  
Author(s):  
Bruggisser ◽  
Terraciano ◽  
Rätz Bravo ◽  
Haschke
Keyword(s):  
Liver Injury ◽  
Wird Eine ◽  
Drug Induced ◽  
Drug Induced Liver Injury

Ein 71-jähriger Patient stellt sich mit Epistaxis und ikterischen Skleren auf der Notfallstation vor. Der Patient steht unter einer Therapie mit Phenprocoumon, Atorvastatin und Perindopril. Anamnestisch besteht ein langjähriger Alkoholabusus. Laborchemisch werden massiv erhöhte Leberwerte (ALAT, Bilirubin) gesehen. Der INR ist unter oraler Antikoagulation und bei akuter Leberinsuffizienz >12. Die weiterführenden Abklärungen schliessen eine Virushepatitis und eine Autoimmunhepatitis aus. Nachdem eine Leberbiopsie durchgeführt werden kann, wird eine medikamentös-toxische Hepatitis, ausgelöst durch die Komedikation von Atorvastatin, Phenprocoumon und Perindopril bei durch Alkohol bereits vorgeschädigter Leber diagnostiziert. Epidemiologie, Pathophysiologie und Klink der medikamentös induzierten Leberschäden (drug induced liver injury, DILI), speziell von Coumarinen, Statinen und ACE-Hemmern werden im Anschluss an den Fallbericht diskutiert.

Drug-induced liver injury network (DILIN)

Hepatology ◽  
2004 ◽  
Vol 40 (4) ◽  
pp. 773-773 ◽  
Author(s):  
Jay H. Hoofnagle
Keyword(s):  
Liver Injury ◽  
Drug Induced ◽  
Drug Induced Liver Injury
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