scholarly journals Drug induced liver damage in a universitary hospital

2019 ◽  
Vol 18 (2) ◽  
pp. 201
Author(s):  
Mariana Porto Magalhaes ◽  
Raymundo Paraná ◽  
Genário Oliveira Santos Junior ◽  
Caio Gomes dos Santos Araújo ◽  
Vinicius Santos Nunes ◽  
...  
Keyword(s):  
Liver Injury ◽  
Dietary Supplements ◽  
International Organizations ◽  
Wide Spectrum ◽  
University Hospital ◽  
Medical Sciences ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Central Nervous System Drugs ◽  
Injury Causes

<strong>Background:</strong> Drug Induced Liver Injury (DILI) is responsible for wide spectrum of liver injury. Clinically, these events are presented in various forms and for reaching a different diagnosis other injury causes must be excluded. <strong>Aim:</strong> Identify and characterize cases of hepatotoxicity induced by drugs, herbal and dietary supplements in University Hospital in Brazil. <strong>Material and Methods: </strong>Observational and retrospective study. Was collected in records of University Hospital, between August 2009 at August 2014. The causality of the drug reactions suspected were evaluated Council for International Organizations of Medical Sciences (CIOMS). <strong>Results:</strong> We selected 30 suspected cases, 50% was female and average was 39 years. The therapeutic classes most common was: anti-infectives; antineoplastic agents; central nervous system drugs, anabolic steroid and herbal and dietary supplements (HDS). Cholestatic or mixed injury was observed in 73% these cases; 60% were highly probable, according to CIOMS.  <strong>Conclusion:</strong> DILI is caused by a wide variety of drugs, dietary supplements and dietary supplements. Anti-infectives and chemotherapy were responsible for much of the response

scholarly journals Characterisation of Drug-Induced Liver Injury in Patients with COVID-19 Detected by a Proactive Pharmacovigilance Program from Laboratory Signals

2021 ◽  
Vol 10 (19) ◽  
pp. 4432
Author(s):  
Ana Delgado ◽  
Stefan Stewart ◽  
Mikel Urroz ◽  
Amelia Rodríguez ◽  
Alberto M. Borobia ◽  
...  
Keyword(s):  
Liver Injury ◽  
Wide Spectrum ◽  
Clinical Manifestations ◽  
Lymphocyte Transformation ◽  
University Hospital ◽  
Small Subset ◽  
Causality Analysis ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Defined Daily Doses

Coronavirus disease 2019 (COVID-19) has a wide spectrum of clinical manifestations. An elevation of liver damage markers has been observed in numerous cases, which could be related to the empirical use of potentially hepatotoxic drugs. The aim of this study was to describe the clinical and analytical characteristics and perform a causality analysis from laboratory signals available of drug-induced liver injury (DILI) detected by a proactive pharmacovigilance program in patients hospitalised for COVID-19 at La Paz University Hospital in Madrid (Spain) from 1 March 2020 to 31 December 2020. The updated Roussel Uclaf Causality Assessment Method (RUCAM) was employed to assess DILI causality. A lymphocyte transformation test (LTT) was performed on 10 patients. Ultimately, 160 patients were included. The incidence of DILI (alanine aminotransferase >5, upper limit of normal) was 4.9%; of these, 60% had previous COVID-19 hepatitis, the stay was 8.1 days longer and 98.1% were being treated with more than 5 drugs. The most frequent mechanism was hepatocellular (57.5%), with mild severity (87.5%) and subsequent recovery (88.1%). The most commonly associated drugs were hydroxychloroquine, azithromycin, tocilizumab and ceftriaxone. The highest incidence rate of DILI per 10,000 defined daily doses (DDD) was with remdesivir (992.7/10,000 DDD). Some 80% of the LTTs performed were positive, with a RUCAM score of ≥4. The presence of DILI after COVID-19 was associated with longer hospital stays. An immune mechanism has been demonstrated in a small subset of DILI cases.

scholarly journals Epidemiology of drug-induced liver injury in a University Hospital from Colombia: Updated RUCAM being used for prospective causality assessment

2019 ◽  
Vol 18 (3) ◽  
pp. 501-507 ◽  
Author(s):  
Alejandra Cano-Paniagua ◽  
Pedro Amariles ◽  
Nancy Angulo ◽  
Margarita Restrepo-Garay
Keyword(s):  
Liver Injury ◽  
Causality Assessment ◽  
University Hospital ◽  
Drug Induced ◽  
Drug Induced Liver Injury

scholarly journals Drug-induced Liver Injury Due to a Horse Chestnut Dietary Supplement

2021 ◽  
Author(s):  
Diogo Costa Santos ◽  
Graça Lérias ◽  
Isabel Madruga
Keyword(s):  
Liver Injury ◽  
Dietary Supplements ◽  
Venous Insufficiency ◽  
Acute Liver Injury ◽  
Western World ◽  
Horse Chestnut ◽  
Drug Induced ◽  
Common Cause ◽  
Drug Induced Liver Injury ◽  
Clinically Significant

Drug-induced liver injury (DILI) is the most common cause of acute liver failure in the Western world. In recent years, natural herbal and dietary supplements have become widely available to the general public and have increased in popularity. Reports of idiosyncratic liver injury caused by such supplements have also increased over the last decade. Horse chestnut is a herb used in dietary supplements primarily for complications of venous insufficiency. Clinically significant acute liver injury has been very rarely associated with its use. We present the case of a 70-year-old man with idiosyncratic horse chestnut-induced liver injury.

Drug-induced liver injury in a Swedish University hospital out-patient hepatology clinic

2006 ◽  
Vol 24 (8) ◽  
pp. 1187-1195 ◽  
Author(s):  
M. B. DE VALLE ◽  
V. AV KLINTEBERG ◽  
N. ALEM ◽  
R. OLSSON ◽  
E. BJÖRNSSON
Keyword(s):  
Liver Injury ◽  
University Hospital ◽  
Drug Induced ◽  
Drug Induced Liver Injury

1144 SINGLE CENTER EXPERIENCE OF 313 PATIENTS WITH DRUG INDUCED LIVER INJURY: CAUSES, OUTCOME, PROGNOSIS AND RISK FACTORS FOR MORTALITY

2010 ◽  
Vol 52 ◽  
pp. S442
Author(s):  
H. Devarbhavi ◽  
R. Dierkhsing ◽  
W. Kremers ◽  
M. Sandeep ◽  
D. Karanth ◽  
...  
Keyword(s):  
Risk Factors ◽  
Liver Injury ◽  
Single Center ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Single Center Experience ◽  
Injury Causes

Monocyte-Derived Hepatocyte-Like Cell Test: A Novel Tool for in vitro Identification of Drug-Induced Liver Injury in Patients with Herbal or Dietary Supplements

Digestion ◽  
2020 ◽  
pp. 1-4
Author(s):  
Sabine Weber ◽  
Grace L.H. Wong ◽  
Vincent W.S. Wong ◽  
Andreas Benesic ◽  
Henry L.Y. Chan ◽  
...  
Keyword(s):  
Liver Injury ◽  
Dietary Supplements ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Cell Test
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