scholarly journals Changes in the Atrial Substrate Alters the Spatiotemporal Organization and Characteristics of Atrial Fibrillation

10.5772/27150 ◽  
2012 ◽  
Author(s):  
Thomas H.
Keyword(s):  
Atrial Fibrillation ◽  
Spatiotemporal Organization

Effect of Electrical and Structural Remodeling on Spatiotemporal Organization in Acute and Persistent Atrial Fibrillation

2002 ◽  
Vol 13 (10) ◽  
pp. 1027-1034 ◽  
Author(s):  
JOSEPH G. AKAR ◽  
THOMAS H. EVERETT ◽  
LAI-CHOW KOK ◽  
J. RANDALL MOORMAN ◽  
DAVID E. HAINES
Keyword(s):  
Atrial Fibrillation ◽  
Persistent Atrial Fibrillation ◽  
Spatiotemporal Organization ◽  
Structural Remodeling

scholarly journals Spatiotemporal Organization of the Left Atrial Substrate After Circumferential Pulmonary Vein Isolation of Atrial Fibrillation

2009 ◽  
Vol 2 (3) ◽  
pp. 233-241 ◽  
Author(s):  
Yenn-Jiang Lin ◽  
Ching-Tai Tai ◽  
Tsair Kao ◽  
Shih-Lin Chang ◽  
Li-Wei Lo ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Pulmonary Vein ◽  
Pulmonary Vein Isolation ◽  
Left Atrial ◽  
Spatiotemporal Organization ◽  
Circumferential Pulmonary Vein Isolation

Left atrial dilatation resulting from chronic mitral regurgitation decreases spatiotemporal organization of atrial fibrillation in left atrium

2004 ◽  
Vol 286 (6) ◽  
pp. H2452-H2460 ◽  
Author(s):  
Thomas H. Everett ◽  
Sander Verheule ◽  
Emily E. Wilson ◽  
Scott Foreman ◽  
Jeffrey E. Olgin
Keyword(s):  
Atrial Fibrillation ◽  
Mitral Regurgitation ◽  
Correlation Coefficients ◽  
Dominant Frequency ◽  
Frequency Domain Analysis ◽  
Atrial Pacing ◽  
Spatiotemporal Organization ◽  
Photodiode Array ◽  
The Right ◽  
And Control

Atrial conduction properties have been shown to differ among animal atrial fibrillation (AF) models of rapid atrial pacing (RAP), chronic mitral regurgitation (MR), and control. We hypothesized that these conduction differences would continue with the onset of AF, which would affect AF spatiotemporal organization, resulting in model-specific characteristics of AF. With frequency domain analysis of electrograms acquired from high-density optical mapping, AF from the right (RA) and left (LA) atrium in animals with RAP and MR were compared with control animals. At follow-up, the hearts were excised and perfused, and optical action potentials were recorded from a 2 × 2-cm area each of the RA and LA free wall with a 16 × 16 photodiode array. AF was induced with extra stimuli, several 2.4-s AF episodes were recorded in each dog, and a fast Fourier transform was calculated. The dominant frequency (DF) was determined, and the organization (organization index, OI) was calculated as the ratio of the area under the dominant peak and its harmonics to the total area of the spectrum. All possible pairs of electrograms for each episode were cross-correlated. LA AF in the chronic MR model showed an increase in the highest DF, the number of DF domains, and in frequency gradient compared with AF in control or RAP models. In addition, there was a decrease in OI and in the correlation coefficients in the LA of the MR model. These results suggest that the AF substrate in the MR model may be different from that of control or RAP models.

Spatiotemporal Organization and Fractionation in Patients with Valvular and Non-valvular Atrial Fibrillation

2009 ◽  
Vol 18 ◽  
pp. S137-S138
Author(s):  
B. John ◽  
C.X. Wong ◽  
M.K. Stiles ◽  
A.G. Brooks ◽  
P. Sciscio ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Spatiotemporal Organization

Effects of atrial fibrillation substrate and spatiotemporal organization on atrial defibrillation thresholds

Heart Rhythm ◽  
2007 ◽  
Vol 4 (8) ◽  
pp. 1048-1056 ◽  
Author(s):  
Thomas H. Everett ◽  
Emily E. Wilson ◽  
Jeffrey E. Olgin
Keyword(s):  
Atrial Fibrillation ◽  
Spatiotemporal Organization ◽  
Atrial Defibrillation

Spatiotemporal organization during ablation of persistent atrial fibrillation

Heart Rhythm ◽  
2015 ◽  
Vol 12 (9) ◽  
pp. 1937-1944 ◽  
Author(s):  
Shahriar Iravanian ◽  
Jonathan J. Langberg
Keyword(s):  
Atrial Fibrillation ◽  
Persistent Atrial Fibrillation ◽  
Spatiotemporal Organization

Role of atrial substrate and spatiotemporal organization in atrial fibrillation

Heart Rhythm ◽  
2009 ◽  
Vol 6 (8) ◽  
pp. S1-S7 ◽  
Author(s):  
Albert M. Kim ◽  
Jeffrey E. Olgin ◽  
Thomas H. Everett
Keyword(s):  
Atrial Fibrillation ◽  
Spatiotemporal Organization

scholarly journals Structural atrial remodeling alters the substrate and spatiotemporal organization of atrial fibrillation: a comparison in canine models of structural and electrical atrial remodeling

2006 ◽  
Vol 291 (6) ◽  
pp. H2911-H2923 ◽  
Author(s):  
Thomas H. Everett ◽  
Emily E. Wilson ◽  
Sander Verheule ◽  
Jose M. Guerra ◽  
Scott Foreman ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
High Frequency ◽  
Dominant Frequency ◽  
Electrical Remodeling ◽  
Atrial Remodeling ◽  
Atrial Pacing ◽  
Spatiotemporal Organization ◽  
Structural Remodeling ◽  
Temporal Variance ◽  
Control Right

Several animal models of atrial fibrillation (AF) have been developed that demonstrate either atrial structural remodeling or atrial electrical remodeling, but the characteristics and spatiotemporal organization of the AF between the models have not been compared. Thirty-nine dogs were divided into five groups: rapid atrial pacing (RAP), chronic mitral regurgitation (MR), congestive heart failure (CHF), methylcholine (Meth), and control. Right and left atria (RA and LA, respectively) were simultaneously mapped during episodes of AF in each animal using high-density (240 electrodes) epicardial arrays. Multiple 30-s AF epochs were recorded in each dog. Fast Fourier transform was calculated every 1 s over a sliding 2-s window, and dominant frequency (DF) was determined. Stable, discrete, high-frequency areas were seen in none of the RAP or control dogs, four of nine MR dogs, four of six CHF dogs, and seven of nine Meth dogs in either the RA or LA or both. Average DFs in the Meth model were significantly greater than in all other models in both LA and RA except LA DFs in the RAP model. The RAP model was the only one with a consistent LA-to-RA DF gradient (9.5 ± 0.2 vs. 8.3 ± 0.3 Hz, P < 0.00005). The Meth model had a higher spatial and temporal variance of DFs and lower measured organization levels compared with the other AF models, and it was the only model to show a linear relationship between the highest DF and dispersion ( R2 = 0.86). These data indicate that structural remodeling of atria (models known to have predominantly altered conduction) leads to an AF characterized by a stable high-frequency area, whereas electrical remodeling of atria (models known to have predominantly shortened refractoriness without significant conduction abnormalities) leads to an AF characterized by multiple high-frequency areas and multiple wavelets.

scholarly journals Evaluation of spatiotemporal organization of persistent atrial fibrillation with time- and frequency-domain measures in humans

EP Europace ◽  
2009 ◽  
Vol 11 (3) ◽  
pp. 316-323 ◽  
Author(s):  
R. F. Berntsen ◽  
A. Cheng ◽  
H. Calkins ◽  
R. D. Berger
Keyword(s):  
Atrial Fibrillation ◽  
Frequency Domain ◽  
Persistent Atrial Fibrillation ◽  
Spatiotemporal Organization

scholarly journals Measures of spatiotemporal organization differentiate persistent from long-standing atrial fibrillation

EP Europace ◽  
2012 ◽  
Vol 14 (8) ◽  
pp. 1125-1131 ◽  
Author(s):  
L. Uldry ◽  
J. Van Zaen ◽  
Y. Prudat ◽  
L. Kappenberger ◽  
J.-M. Vesin
Keyword(s):  
Atrial Fibrillation ◽  
Spatiotemporal Organization
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