Epithelioid Cell: A New Opinion on Its Nature, Parentage, Histogenesis, Cytomorphogenesis, Morphofunctional Potency, Role in Pathogenesis and Morphogenesis of Tuberculous Process

Perivascular epithelioid cell tumor (PEComa) is a rare mesenchymal neoplasm characterized by expression of both mela-nocytic and smooth muscle markers. Only 10 primary malignant lung PEComas have been reported up to date. We report a 59-year-old male who presented with a lung neoplasm, found during the routine X-ray examination. Preoperative CT-scan revealed the 3,5-cm-sized mass, located at the border of the upper, middle and lower lobes of the right lung. Patient underwent a thoracotomy, resection of the upper, middle and lower lobes of the right lung accompanied with mediastinal lymphadenectomy. After surgery, chylothorax was revealed. Conservative treatment was unsuccessful, so we performed laparoscopic clipping of the thoracic lymph duct. Patient was dismissed from hospital on the 10-th day after the second operation in good condition. In this report, we intend to increase the limited knowledge relating to natural history and optimal treatment of such a rare condition as a primary malignant lung PEComa.

Bladder perivascular epithelioid cell neoplasm: The importance of immunohistochemistry in the diagnosis of an unusual neoplasm

SAGE Open Medical Case Reports ◽

10.1177/2050313x211000868 ◽

2021 ◽

Vol 9 ◽

pp. 2050313X2110008

Author(s):

Solange De Noon ◽

Benjamin Ayres ◽

Uday Patel ◽

Rami Issa ◽

Colan Maxwell Ho-Yen

Keyword(s):

Differential Diagnosis ◽

Epithelioid Cell ◽

Review Of The Literature ◽

Histological Features ◽

Perivascular Epithelioid Cell Neoplasms ◽

Perivascular Epithelioid Cell ◽

Organ Systems ◽

Cell Neoplasm ◽

Key Features ◽

Mesenchymal Tumours

Perivascular epithelioid cell neoplasms represent a group of uncommon mesenchymal tumours with as yet undiscovered benign counterpart. Although perivascular epithelioid cell neoplasms have been described arising in most organ systems as well as in soft tissue and bone, only a small number of perivascular epithelioid cell neoplasms have been reported in the bladder. To date, there is no agreed system for predicting the behaviour of these tumours. We describe a case of a perivascular epithelioid cell neoplasm of the bladder arising in a 57-year-old male and initially diagnosed on biopsy and present a review of the literature focussing on the pathological differential diagnosis and the importance of key histological features in conjunction with a broad immunohistochemical panel. This case report highlights the key features of bladder perivascular epithelioid cell neoplasms that distinguishes these rare neoplasms from other bladder lesions.

Hepatocellular carcinoma with regional lymphadenopathy caused by sarcoid-like reaction: a case report

Surgical Case Reports ◽

10.1186/s40792-021-01146-2 ◽

2021 ◽

Vol 7 (1) ◽

Author(s):

Tomoko Mizota ◽

Masato Suzuoki ◽

Saya Kaku ◽

Kenichi Mizunuma ◽

Kazuto Ohtaka ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Lymph Node ◽

Lymph Nodes ◽

Granulomatous Inflammation ◽

Giant Cells ◽

Epithelioid Cell ◽

Imaging Modalities ◽

Hepatoduodenal Ligament ◽

Regional Lymph Nodes ◽

Multiple Imaging

Abstract Background Sarcoid-like reaction (SLR) is a histological pattern of granulomatous inflammation that is clinically differentiated from sarcoidosis. Since SLR is known to occur in several neoplasias and occasionally causes lymphadenopathy and mimics metastatic malignancy, it needs to be considered whether lymphadenopathy is due to metastasis or SLR for the choice of cancer treatment. Few cases of hepatocellular carcinoma (HCC) with SLR have been reported. Here, a case of HCC with lymphadenopathy diagnosed as SLR without metastasis is presented. Case presentation A 69-year-old woman was admitted to our hospital because of upper abdominal pain. She tested positive for hepatitis C virus ribonucleic acid. Imaging modalities showed an 81 × 65-mm-sized tumor with multiple nodules in segment 3 and a 17 × 12-mm-sized tumor in segment 5 with a common HCC enhancement pattern. In addition, a lymph node in the hepatoduodenal ligament was enlarged at 13 mm in size, suggesting the metastasis of HCC. Hepatectomy of the lateral segment and segment 5 and lymph node dissection in the hepatoduodenal ligament were performed. Both tumors in segments 3 and 5 were pathologically diagnosed as HCC without vessel invasion. The tumors contained necrotic cells and epithelioid cell granulomas with multinucleated giant cells, which is typically observed in sarcoidosis. The dissected lymph nodes also contained epithelioid cell granulomas, as well as giant cells with asteroid bodies. There was no malignancy in the lymph nodes. The pathological findings suggested the coexistence of malignancy and sarcoidosis. However, since the patient did not show any typical findings of pulmonary or cardiac sarcoidosis, the case was diagnosed as HCC with SLR in the primary lesion and regional lymph nodes. Conclusions SLR needs to be considered in the differential diagnosis when a cancer patient develops lymphadenopathy. However, lymphadenopathy due to SLR is indistinguishable from that due to metastasis even when using multiple imaging modalities. Pathological examinations may be helpful for the diagnosis.

The neutrophil chemoattractant produced by the rat kidney epithelioid cell line NRK-52E is a protein related to the KC/gro protein

Journal of Biological Chemistry ◽

10.1016/s0021-9258(19)47149-4 ◽

1989 ◽

Vol 264 (33) ◽

pp. 19559-19563

Author(s):

K Watanabe ◽

K Konishi ◽

M Fujioka ◽

S Kinoshita ◽

H Nakagawa

Keyword(s):

Cell Line ◽

Rat Kidney ◽

Epithelioid Cell