scholarly journals Diagnosis of Prostatic Intraepithelial Neoplasia in Luminal Cells Using Raman Spectroscopy

10.5772/32684 ◽  
2012 ◽  
Author(s):  
Suneetha Devpura ◽  
Jagdish Thakur ◽  
Seema Sethi ◽  
Vaman M. ◽  
Fazlul Sarkar ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Intraepithelial Neoplasia ◽  
Prostatic Intraepithelial Neoplasia ◽  
Luminal Cells

Detection of benign epithelia, prostatic intraepithelial neoplasia, and cancer regions in radical prostatectomy tissues using Raman spectroscopy

2010 ◽  
Vol 53 (2) ◽  
pp. 227-232 ◽  
Author(s):  
Suneetha Devpura ◽  
Jagdish S. Thakur ◽  
Fazlul H. Sarkar ◽  
Wael A. Sakr ◽  
Vaman M. Naik ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Radical Prostatectomy ◽  
Intraepithelial Neoplasia ◽  
Prostatic Intraepithelial Neoplasia

523: Risk of Prostate Cancer on Re-Biopsy Following a Diagnosis of High-Grade Prostatic Intraepithelial Neoplasia (HGPIN) is Related to the Number of Cores Sampled

2005 ◽  
Vol 173 (4S) ◽  
pp. 142-143 ◽  
Author(s):  
Mehsati Herawi ◽  
Christina Cavallo ◽  
Hillel Kahane ◽  
Jonathan I. Epstein
Keyword(s):  
Prostate Cancer ◽  
Intraepithelial Neoplasia ◽  
Prostatic Intraepithelial Neoplasia ◽  
High Grade

1714: Comparison of Contrast Enhanced Color Doppler Targeted Versus Extended 10 Core Repeat Biopsy Strategy in Patients with Previous Prostatic Intraepithelial Neoplasia (HGPIN)

2005 ◽  
Vol 173 (4S) ◽  
pp. 465-465
Author(s):  
Christian Wiunig ◽  
Josef Pointner ◽  
Stefan Obwexer ◽  
Ralph Meyer-Venter ◽  
Michael Aigner ◽  
...  
Keyword(s):  
Color Doppler ◽  
Intraepithelial Neoplasia ◽  
Prostatic Intraepithelial Neoplasia ◽  
Repeat Biopsy ◽  
Contrast Enhanced

scholarly journals Glyoxalase 1 Expression as a Novel Diagnostic Marker of High-Grade Prostatic Intraepithelial Neoplasia in Prostate Cancer

Cancers ◽  
2021 ◽  
Vol 13 (14) ◽  
pp. 3608
Author(s):  
Liliana Rounds ◽  
Ray B. Nagle ◽  
Andrea Muranyi ◽  
Jana Jandova ◽  
Scott Gill ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Diagnostic Marker ◽  
Precancerous Lesion ◽  
Immunohistochemical Analysis ◽  
Intraepithelial Neoplasia ◽  
Prostatic Intraepithelial Neoplasia ◽  
Glycolytic Flux ◽  
Gleason Grade ◽  
High Grade ◽  
Glyoxalase 1

Glyoxalase 1 (GLO1) is an enzyme involved in the detoxification of methylglyoxal (MG), a reactive oncometabolite formed in the context of energy metabolism as a result of high glycolytic flux. Prior clinical evidence has documented GLO1 upregulation in various tumor types including prostate cancer (PCa). However, GLO1 expression has not been explored in the context of PCa progression with a focus on high-grade prostatic intraepithelial neoplasia (HGPIN), a frequent precursor to invasive cancer. Here, we have evaluated GLO1 expression by immunohistochemistry in archival tumor samples from 187 PCa patients (stage 2 and 3). Immunohistochemical analysis revealed GLO1 upregulation during tumor progression, observable in HGPIN and PCa versus normal prostatic tissue. GLO1 upregulation was identified as a novel hallmark of HGPIN lesions, displaying the highest staining intensity in all clinical patient specimens. GLO1 expression correlated with intermediate–high risk Gleason grade but not with patient age, biochemical recurrence, or pathological stage. Our data identify upregulated GLO1 expression as a molecular hallmark of HGPIN lesions detectable by immunohistochemical analysis. Since current pathological assessment of HGPIN status solely depends on morphological features, GLO1 may serve as a novel diagnostic marker that identifies this precancerous lesion.

Natural history of widespread high grade prostatic intraepithelial neoplasia and atypical small acinar proliferation: should we rebiopsy them all?

2021 ◽  
pp. 1-6
Author(s):  
Marco Oderda ◽  
Matteo Rosazza ◽  
Marco Agnello ◽  
Maurizio Barale ◽  
Giorgio Calleris ◽  
...  
Keyword(s):  
Natural History ◽  
Intraepithelial Neoplasia ◽  
Prostatic Intraepithelial Neoplasia ◽  
High Grade ◽  
Atypical Small Acinar Proliferation ◽  
History Of

Foamy Gland High-Grade Prostatic Intraepithelial Neoplasia

2000 ◽  
Vol 24 (1) ◽  
pp. 140 ◽  
Author(s):  
David M. Berman ◽  
Jiming Yang ◽  
Jonathan I. Epstein
Keyword(s):  
Intraepithelial Neoplasia ◽  
Prostatic Intraepithelial Neoplasia ◽  
High Grade

High-Grade Prostatic Intraepithelial Neoplasia in Patients with Prostate Cancer: MR and MR Spectroscopic Imaging Features—Initial Experience

Radiology ◽  
2007 ◽  
Vol 242 (2) ◽  
pp. 483-489 ◽  
Author(s):  
Jeffrey J. Hom ◽  
Fergus V. Coakley ◽  
Jeffry P. Simko ◽  
Ying Lu ◽  
Aliya Qayyum ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Spectroscopic Imaging ◽  
Intraepithelial Neoplasia ◽  
Prostatic Intraepithelial Neoplasia ◽  
Imaging Features ◽  
High Grade ◽  
Initial Experience ◽  
Mr Spectroscopic Imaging

Clinicopathological analysis of intraductal proliferative lesions of prostate: intraductal carcinoma of prostate, high-grade prostatic intraepithelial neoplasia, and atypical cribriform lesion

2014 ◽  
Vol 45 (8) ◽  
pp. 1572-1581 ◽  
Author(s):  
Kosuke Miyai ◽  
Mukul K. Divatia ◽  
Steven S. Shen ◽  
Brian J. Miles ◽  
Alberto G. Ayala ◽  
...  
Keyword(s):  
Intraepithelial Neoplasia ◽  
Prostatic Intraepithelial Neoplasia ◽  
Intraductal Carcinoma ◽  
High Grade ◽  
Clinicopathological Analysis
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