scholarly journals Fasudil (a Rho Kinase Inhibitor) Specifically Increases Cerebral Blood Flow in Area of Vasospasm After Subarachnoid Hemorrhage

10.5772/34012 ◽  
2012 ◽  
Author(s):  
Masato Shibuya ◽  
Kenko Meda ◽  
Akira Ike
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Subarachnoid Hemorrhage ◽  
Kinase Inhibitor ◽  
Rho Kinase ◽  
Rho Kinase Inhibitor

Pleiotropic Effects of the Rho-kinase Inhibitor Fasudil After Subarachnoid Hemorrhage: A Review of Preclinical and Clinical Studies

2014 ◽  
Vol 12 (5) ◽  
pp. 758-765 ◽  
Author(s):  
Shin-ichi Satoh ◽  
Ichiro Ikegaki ◽  
Koh Kawasaki ◽  
Toshio Asano ◽  
Masato Shibuya
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Clinical Studies ◽  
Kinase Inhibitor ◽  
Rho Kinase ◽  
Pleiotropic Effects ◽  
Rho Kinase Inhibitor ◽  
Preclinical And Clinical Studies

Effects of ripasudil, a rho kinase inhibitor, on blood flow in the optic nerve head of normal rats

2018 ◽  
Vol 257 (2) ◽  
pp. 303-311 ◽  
Author(s):  
Yasushi Wada ◽  
Tomomi Higashide ◽  
Atsushi Nagata ◽  
Kazuhisa Sugiyama
Keyword(s):  
Blood Flow ◽  
Optic Nerve ◽  
Optic Nerve Head ◽  
Kinase Inhibitor ◽  
Rho Kinase ◽  
Rho Kinase Inhibitor

scholarly journals Antivasospastic Effects of Hydroxyfasudil, a Rho-Kinase Inhibitor, After Subarachnoid Hemorrhage

2012 ◽  
Vol 118 (1) ◽  
pp. 92-98 ◽  
Author(s):  
Shin-ichi Satoh ◽  
Masakazu Takayasu ◽  
Koh Kawasaki ◽  
Ichiro Ikegaki ◽  
Asako Hitomi ◽  
...  
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Kinase Inhibitor ◽  
Rho Kinase ◽  
Rho Kinase Inhibitor

Rho kinase regulates renal blood flow by modulating eNOS activity in ischemia-reperfusion of the rat kidney

2006 ◽  
Vol 291 (3) ◽  
pp. F606-F611 ◽  
Author(s):  
Amanda M. G. Versteilen ◽  
Iolente J. M. Korstjens ◽  
René J. P. Musters ◽  
A. B. Johan Groeneveld ◽  
Pieter Sipkema
Keyword(s):  
Nitric Oxide ◽  
Blood Flow ◽  
Renal Blood Flow ◽  
Kinase Inhibitor ◽  
Ex Vivo ◽  
Rat Kidney ◽  
Ischemia Reperfusion ◽  
Rho Kinase ◽  
Rho Kinase Inhibitor

Renal ischemia-reperfusion (I/R) results in vascular dysfunction characterized by a reduced endothelium-dependent vasodilatation and subsequently impaired blood flow. In this study, we investigated the role of Rho kinase in endothelial nitric oxide synthase (eNOS)-mediated regulation of renal blood flow and vasomotor tone in renal I/R. Male Wistar rats were subjected to 60-min bilateral clamping of the renal arteries or sham procedure. One hour before the clamping, the Rho kinase inhibitor Y27632 (1 mg/kg) was intravenously infused. After I/R, renal blood flow was measured using fluorescent microspheres. I/R resulted in a 62% decrease in renal blood flow. In contrast, the blood flow decrease in the group treated with the Rho kinase inhibitor (YI/R) was prevented. Endothelium-dependent vasodilatation of renal arcuate arteries to ACh was measured ex vivo in a pressure myograph. These experiments demonstrated that the in vivo treatment with the Rho kinase inhibitor prevented the decrease in the nitric oxide (NO)-mediated vasodilator response. In addition, after I/R renal interlobar arteries showed a decrease in phosphorylated eNOS and vasodilator-stimulated phosphoprotein, a marker for bioactive NO, which was attenuated by in vivo Rho kinase inhibition. These findings indicate that in vivo inhibition of Rho kinase in renal I/R preserves renal blood flow by improving eNOS function.

1444: Functional Effect of the Novel Rho-Kinase Inhibitor H-1152 in the Erectile Machinery

2004 ◽  
Vol 171 (4S) ◽  
pp. 380-380
Author(s):  
Cleber E. Teixeira ◽  
R. Clinton Webb
Keyword(s):  
Kinase Inhibitor ◽  
Rho Kinase ◽  
The Novel ◽  
Functional Effect ◽  
Rho Kinase Inhibitor

Cerebral blood flow changes in acute subarachnoid hemorrhage

10.2741/2783 ◽  
2008 ◽  
Vol 13 (13) ◽  
pp. 1594 ◽  
Author(s):  
Gerrit Alexander Schubert
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Subarachnoid Hemorrhage ◽  
Acute Subarachnoid Hemorrhage ◽  
Flow Changes

A Rho kinase inhibitor (Fasudil) suppresses TGF-β mediated autophagy in urethra fibroblasts to attenuate traumatic urethral stricture (TUS) through re-activating Akt/mTOR pathway: An in vitro study

Life Sciences ◽  
2021 ◽  
Vol 267 ◽  
pp. 118960
Author(s):  
Huan Feng ◽  
Xiaobing Huang ◽  
Weihua Fu ◽  
Xingyou Dong ◽  
Fengxia Yang ◽  
...  
Keyword(s):  
Urethral Stricture ◽  
Kinase Inhibitor ◽  
Rho Kinase ◽  
In Vitro Study ◽  
Mtor Pathway ◽  
Vitro Study ◽  
Rho Kinase Inhibitor
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