scholarly journals Dual Role of TLR3 in Inflammation and Cancer Cell Apoptosis

10.5772/54772 ◽  
2013 ◽  
Author(s):  
Yann Estornes ◽  
Olivier Micheau ◽  
Toufic Renno ◽  
Serge Lebecque
Keyword(s):  
Cancer Cell ◽  
Cell Apoptosis ◽  
Dual Role ◽  
Cancer Cell Apoptosis

Role of Nuclear Factor-KB in Colon Cancer Cell Apoptosis Mediated by Aminopyropheophorbide Photosensitization

1999 ◽  
Vol 70 (4) ◽  
pp. 540-548 ◽  
Author(s):  
Jean-Yves Matroule ◽  
Anne-Cecile Hellin ◽  
Patrice Morliere ◽  
A.-S. Fabiano ◽  
Rend Santus ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cell ◽  
Cell Apoptosis ◽  
Colon Cancer Cell ◽  
Nuclear Factor ◽  
Cancer Cell Apoptosis ◽  
Nuclear Factor Kb

scholarly journals Histone Methyltransferase WHSC1 Inhibits Colorectal Cancer Cell Apoptosis via Targeting Anti-apoptotic BCL2

2020 ◽  
Author(s):  
Yu Wang ◽  
Xin Tang ◽  
Mei Guo ◽  
Gang Sun ◽  
Kun Zhou ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cell ◽  
Cell Apoptosis ◽  
Xenograft Model ◽  
Histone Methyltransferase ◽  
Cancer Cell Apoptosis ◽  
Mechanistic Investigation

Abstract Background: WHSC1 is a histone methyltransferase that facilitates histone H3 lysine 36 dimethylation (H3K36me2), which is a permissive mark associated with active transcription. Colorectal cancer (CRC) is the 4th deadliest and 3rd most frequent cancer globally. However, the role of WHSC1 in CRC progression remains unknown. Methods: qRT-PCR, immunoblotting assays (WB), and immunohistochemistry (IHC) staining was performed to investigate WHSC1 expression levels in CRC tissues and normal tissues. CCK-8 assays, colony formation assays, and flow cytometry were also used to assess the effect of WHSC1 depletion in CRC cell proliferation, apoptosis and oxaliplatin sensitivity in vitro. A cell line-derived xenograft model in nude mice was performed to determine the role of WHSC1 in CRC cell apoptosis in vivo. Results: WHSC1 as well as H3K36me2 were highly expressed in clinical CRC tissues compared with in normal counterparts. High WHSC1 expression was correlated with poorer prognosis in CRC patients. Knockdown of WHSC1 significantly promoted CRC cell apoptosis and inhibited tumour growth in vivo. Further mechanistic investigation revealed that WHSC1 directly binds to the promoter region of BCL2 gene and regulate its H3K36 dimethylation level, so BCL2 expression is markedly decreased after WHSC1 depletion. Conclusions: Our findings demonstrated that knockdown of WHSC1 promoted colon cancer cell apoptosis and suppressed CRC tumorigenesis through targeting BCL2 transcription, suggesting WHSC1 activity may be a potential therapeutic target for the treatment of CRC.

A thiosemicarbazone derivative induces triple negative breast cancer cell apoptosis: possible role of miRNA-125a-5p and miRNA-181a-5p

2019 ◽  
Vol 41 (12) ◽  
pp. 1431-1443 ◽  
Author(s):  
Rania El Majzoub ◽  
Mohammad Fayyad-kazan ◽  
Assaad Nasr El Dine ◽  
Rawan Makki ◽  
Eva Hamade ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Triple Negative Breast Cancer ◽  
Cell Apoptosis ◽  
Triple Negative ◽  
Cancer Cell Apoptosis

Role of Nuclear Factor-κB in Colon Cancer Cell Apoptosis Mediated by Aminopyropheophorbide Photosensitization

1999 ◽  
Vol 70 (4) ◽  
pp. 540 ◽  
Author(s):  
Jean-Yves Matroule ◽  
Anne-Cécile Hellin ◽  
Patrice Morlière ◽  
A.-S. Fabiano ◽  
René Santus ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cell ◽  
Cell Apoptosis ◽  
Nuclear Factor Κb ◽  
Colon Cancer Cell ◽  
Nuclear Factor ◽  
Cancer Cell Apoptosis

scholarly journals Histone Methyltransferase WHSC1 Inhibits Colorectal Cancer Cell Apoptosis via Targeting Anti-apoptotic BCL2

2020 ◽  
Author(s):  
Yu Wang ◽  
Xin Tang ◽  
Mei Guo ◽  
Gang Sun ◽  
Kun Zhou ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cell ◽  
Cell Apoptosis ◽  
Xenograft Model ◽  
Histone Methyltransferase ◽  
Cancer Cell Apoptosis ◽  
Mechanistic Investigation

Abstract Background: WHSC1 is a histone methyltransferase that facilitates histone H3 lysine 36 dimethylation (H3K36me2), which is a permissive mark associated with active transcription. Colorectal cancer (CRC) is the 4th deadliest and 3rd most frequent cancer globally. However, the role of WHSC1 in CRC progression remains unknown.Methods: qRT-PCR, immunoblotting assays (WB), and immunohistochemistry (IHC) staining was performed to investigate WHSC1 expression levels in CRC tissues and normal tissues. CCK-8 assays, colony formation assays, and flow cytometry were also used to assess the effect of WHSC1 depletion in CRC cell proliferation, apoptosis and oxaliplatin sensitivity in vitro. A cell line-derived xenograft model in nude mice was performed to determine the role of WHSC1 in CRC cell apoptosis in vivo.Results: WHSC1 as well as H3K36me2 were highly expressed in clinical CRC tissues compared with in normal counterparts. High WHSC1 expression was correlated with poorer prognosis in CRC patients. Knockdown of WHSC1 significantly promoted CRC cell apoptosis and inhibited tumour growth in vivo. Further mechanistic investigation revealed that WHSC1 directly binds to the promoter region of BCL2 gene and regulate its H3K36 dimethylation level, so BCL2 expression is markedly decreased after WHSC1 depletion.Conclusions: Our findings demonstrated that knockdown of WHSC1 promoted colon cancer cell apoptosis and suppressed CRC tumorigenesis through targeting BCL2 transcription, suggesting WHSC1 activity may be a potential therapeutic target for the treatment of CRC.

Abstract 251: Role of ß-catenin in prostate cancer cell apoptosis

2012 ◽  
Author(s):  
Ramesh P. Thylur ◽  
Nithyananda Thorenoor ◽  
Velusamy Rangasamy ◽  
Ajay Rana ◽  
Basabi Rana
Keyword(s):  
Prostate Cancer ◽  
Cancer Cell ◽  
Cell Apoptosis ◽  
Prostate Cancer Cell ◽  
Cancer Cell Apoptosis

scholarly journals Histone methyltransferase WHSC1 inhibits colorectal cancer cell apoptosis via targeting anti-apoptotic BCL2

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Yu Wang ◽  
Liming Zhu ◽  
Mei Guo ◽  
Gang Sun ◽  
Kun Zhou ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cell ◽  
Cell Apoptosis ◽  
B Cell Lymphoma ◽  
Histone Methyltransferase ◽  
Chemotherapeutic Agents ◽  
Cancer Cell Apoptosis ◽  
Active Transcription

AbstractWHSC1 is a histone methyltransferase that facilitates histone H3 lysine 36 dimethylation (H3K36me2), which is a permissive mark associated with active transcription. In this study, we revealed how WHSC1 regulates tumorigenesis and chemosensitivity of colorectal cancer (CRC). Our data showed that WHSC1 as well as H3K36me2 were highly expressed in clinical CRC samples, and high WHSC1 expression is associated with poorer prognosis in CRC patients. WHSC1 reduction promoted colon cancer cell apoptosis both in vivo and in vitro. We found that B cell lymphoma-2 (BCL2) expression, an anti-apoptotic protein, is markedly decreased in after WHSC1 depletion. Mechanistic characterization indicated that WHSC1 directly binds to the promoter region of BCL2 gene and regulate its H3K36 dimethylation level. What’s more, our study indicated that WHSC1 depletion promotes chemosensitivity in CRC cells. Together, our results suggested that WHSC1 and H3K36me2 modification might be optimal therapeutic targets to disrupt CRC progression and WHSC1-targeted therapy might potentially overcome the resistance of chemotherapeutic agents.

Saccharomyces cerevisiae may serve as a probiotic in colorectal cancer by promoting cancer cell apoptosis

2020 ◽  
Vol 21 (10) ◽  
pp. 571-582
Author(s):  
Jia Qi Li ◽  
Jia Lu Li ◽  
Yuan Hong Xie ◽  
Yao Wang ◽  
Xiao Nan Shen ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Saccharomyces Cerevisiae ◽  
Cancer Cell ◽  
Cell Apoptosis ◽  
Cancer Cell Apoptosis
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