scholarly journals Renin-Angiotensin System and Renal Allograft Long-Term Outcome: A Review

Author(s):  
Rosa M. Viero ◽  
Luis Gustavo Modelli de Andrade

2005 ◽  
Vol 37 (9) ◽  
pp. 3716-3717 ◽  
Author(s):  
A. Rodríguez-Moreno ◽  
A.I. Sánchez-Fructuoso ◽  
N. Ridao-Cano ◽  
N. Calvo ◽  
J. Conesa ◽  
...  




2018 ◽  
Vol 2018 ◽  
pp. 1-5 ◽  
Author(s):  
Haiyan Xu ◽  
Xiaozhou He ◽  
Renfang Xu

Antibody-mediated rejection (ABMR) of renal allograft lacks typical phenotypes and clinical manifestations, always resulting in delayed diagnosis and treatment. It has been considered to be an elemental factor influencing the improvement of the long-term outcome of renal allograft. The B cell activating factor (BAFF) signal plays a fundamental function in the process of antibody-mediated immune response. Data from recipients and the nonhuman primate ABMR model suggest that the BAFF signal participates in the ABMR of renal allograft, while there are objections. The challenges in the diagnosis of ABMR, different study population, and details of research may explain the discrepancy. Large quantities of dynamic, credible data of BAFF ligands and their association with renal allograft pathological characteristics would constitute a direct proof of the role of BAFF in the progression of renal allograft ABMR.



Diabetes ◽  
2021 ◽  
Vol 70 (Supplement 1) ◽  
pp. 1071-P
Author(s):  
MAI SHI ◽  
AIMIN YANG ◽  
ERIC S.H. LAU ◽  
HONGJIANG WU ◽  
BAOQI FAN ◽  
...  


1990 ◽  
Vol 259 (2) ◽  
pp. H543-H553
Author(s):  
R. D. Randall ◽  
B. G. Zimmerman

Rabbits were bilaterally nephrectomized for 24 h or received an angiotensin-converting enzyme (ACE) inhibitor chronically (5 days) before an acute experiment. Conductance responses to sympathetic nerve stimulation (SNS) (0.25, 0.75, and 2.25 Hz) and norepinephrine (NE) administration (0.2, 0.6, and 1.8 micrograms ia) were determined from simultaneous blood pressure and iliac blood flow measurements. Conductance responses to SNS were significantly reduced in nephrectomized (44, 26, and 20%) and chronic ACE inhibition (39, 31, and 24%) groups compared with normal controls, whereas conductance responses to NE were unchanged. Continuous infusion of angiotensin II (ANG II) for 24 h restored the depressed responses to SNS in nephrectomized and chronic ACE inhibition groups compared with normal controls but did not change conductance responses to NE. Acute ACE inhibition did not affect the conductance responses to SNS or NE compared with controls. Vascular tissue ACE activity was inhibited to a similar degree (50%) in both acute and chronic ACE inhibition groups compared with normal rabbits. Sodium depletion increased the conductance responses to SNS (30 and 24% at 0.25 and 0.75 Hz, respectively), but responses to NE were not affected. Chronic ACE inhibition significantly attenuated the conductance responses to SNS and slightly decreased responses to NE in sodium-depleted rabbits. Thus, in the anesthetized rabbit, the renin-angiotensin system potentiates the effect of SNS, presumably by ANG II acting at a prejunctional site, and this effect of ANG II appears to be long term in nature. Therefore, the renin-angiotensin system exerts a physiological role in the control of blood pressure in addition to the ability of this system to support arterial pressure in pathophysiological states.



1994 ◽  
Vol 7 (4) ◽  
pp. 278-283 ◽  
Author(s):  
P.A. Rowe ◽  
K.S. Fan ◽  
S.G. Macpherson ◽  
J.A. Bradley ◽  
R.S.C. Rodger ◽  
...  


2013 ◽  
Vol 15 (10) ◽  
pp. 1194-1202 ◽  
Author(s):  
Chao-Hsiun Tang ◽  
Tso-Hsiao Chen ◽  
Chia-Chen Wang ◽  
Chuang-Ye Hong ◽  
Kuan-Chih Huang ◽  
...  


1986 ◽  
Vol 4 (4) ◽  
pp. 387-397 ◽  
Author(s):  
John E. Hall ◽  
H Leland Mizelle ◽  
Lori L. Woods




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