scholarly journals Immune Regulatory Network in Cervical Cancer Development: The Expanding Role of Innate Immunity Mechanisms

2018 ◽  
Author(s):  
Olga Kurmyshkina ◽  
Pavel Kovchur ◽  
Ludmila Schegoleva ◽  
Tatyana Volkova
Keyword(s):  
Cervical Cancer ◽  
Innate Immunity ◽  
Regulatory Network ◽  
Cancer Development ◽  
Cervical Cancer Development

scholarly journals Role of inflammasome genetics in susceptibility to HPV infection and cervical cancer development

2016 ◽  
Vol 88 (9) ◽  
pp. 1646-1651 ◽  
Author(s):  
A. Pontillo ◽  
P. Bricher ◽  
V.N.C. Leal ◽  
S. Lima ◽  
P.R.E. Souza ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Hpv Infection ◽  
Cancer Development ◽  
Cervical Cancer Development

scholarly journals Identification of a novel circ_0018289/miR-183-5p/TMED5 regulatory network in cervical cancer development

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Heng Zou ◽  
Huijia Chen ◽  
Shuaibin Liu ◽  
Xiaoling Gan
Keyword(s):  
Cervical Cancer ◽  
Cell Proliferation ◽  
Tumor Growth ◽  
Cell Apoptosis ◽  
Regulatory Network ◽  
Molecular Basis ◽  
Tube Formation ◽  
Cancer Development ◽  
Cervical Carcinogenesis ◽  
Cervical Cancer Development

Abstract Background Circular RNAs (circRNAs) are increasingly implicated in regulating human carcinogenesis. Previous work showed the oncogenic activity of circ_0018289 in cervical cancer. However, the molecular basis underlying the modulation of circ_0018289 in cervical carcinogenesis is still not fully understood. Methods The levels of circ_0018289, microRNA (miR)-183-5p, and transmembrane p24 trafficking protein 5 (TMED5) were measured by quantitative real-time polymerase chain reaction (qRT-PCR) or western blot assay. Ribonuclease (RNase) R and subcellular localization assays were used to characterize circ_0018289. Cell proliferation was detected by the Cell Counting Kit-8 (CCK-8) and 5-ethynyl-2′-deoxyuridine (Edu) assays. Cell apoptosis and tube formation were assessed by flow cytometry and tube formation assays, respectively. A dual-luciferase reporter assay was performed to confirm the direct relationship between miR-183-5p and circ_0018289 or TMED5. The role of circ_0018289 in tumor growth was gauged by mouse xenograft experiments. Results Circ_0018289 was overexpressed in cervical cancer tissues and cells. Circ_0018289 silencing impeded cell proliferation, enhanced cell apoptosis, and suppressed angiogenesis in vitro, as well as diminished tumor growth in vivo. Mechanistically, circ_0018289 targeted and regulated miR-183-5p by binding to miR-183-5p, and circ_0018289 regulated cervical cancer development and angiogenesis partially through miR-183-5p. Moreover, TMED5 was directly targeted and inhibited by miR-183-5p through the perfect complementary sites in TMED5 3′UTR, and TMED5 knockdown phenocopied miR-183-5p overexpression in suppressing cervical cancer development and angiogenesis. Furthermore, circ_0018289 induced TMED5 expression by competitively binding to shared miR-183-5p. Conclusion Our observations identified the circ_0018289/miR-183-5p/TMED5 regulatory network as a novel molecular basis underlying the modulation of cervical carcinogenesis.

Role of ganglioside biosynthesis genetic polymorphism in cervical cancer development

2019 ◽  
Vol 40 (8) ◽  
pp. 1127-1132
Author(s):  
Damir Danolic ◽  
Marija Heffer ◽  
Jasenka Wagner ◽  
Ivana Skrlec ◽  
Ilija Alvir ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Genetic Polymorphism ◽  
Cancer Development ◽  
Ganglioside Biosynthesis ◽  
Cervical Cancer Development

scholarly journals Role of ganglioside GM1 expression in T lymphocytes membranes in cervical cancer development

2019 ◽  
Author(s):  
Danolic Damir ◽  
Marija Heffer ◽  
Jasenka Wagner ◽  
Ivana Skrlec ◽  
Ilija Alvir ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
T Lymphocytes ◽  
Cancer Development ◽  
Ganglioside Gm1 ◽  
Cervical Cancer Development

The role of environmental and genetic host factors in cervical cancer development among women from Rio de Janeiro, Brazil

2008 ◽  
Vol 6 (9) ◽  
pp. 205
Author(s):  
I.F. Silva ◽  
R.J. Koifman ◽  
C.Q.S. Souza ◽  
O.F.A. Neto ◽  
S. Koifman
Keyword(s):  
Cervical Cancer ◽  
Rio De Janeiro ◽  
Host Factors ◽  
Cancer Development ◽  
Cervical Cancer Development

EP280 Role of ganglioside GM1 expression in T lymphocytes membranes in cervical cancer development

2019 ◽  
Author(s):  
D Danolic ◽  
M Heffer ◽  
J Wagner ◽  
I Skrlec ◽  
I Alvir ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
T Lymphocytes ◽  
Cancer Development ◽  
Ganglioside Gm1 ◽  
Cervical Cancer Development

scholarly journals A Systematic Review of MicroRNAs Involved in Cervical Cancer Progression

Cells ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 668
Author(s):  
Rhafaela Lima Causin ◽  
Ana Julia Aguiar de Freitas ◽  
Cassio Murilo Trovo Hidalgo Filho ◽  
Ricardo dos Reis ◽  
Rui Manuel Reis ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cervical Cancer ◽  
Cancer Progression ◽  
Cancer Development ◽  
Tissue Samples ◽  
Regulatory Pathways ◽  
Gynecology And Obstetrics ◽  
Cervical Cancer Development ◽  
Proliferative Signaling

To obtain a better understanding on the role of microRNAs in the progression of cervical cancer, a systematic review was performed to analyze cervical cancer microRNA studies. We provide an overview of the studies investigating microRNA expression in relation to cervical cancer (CC) progression, highlighting their common outcomes and target gene interactions according to the regulatory pathways. To achieve this, we systematically searched through PubMed MEDLINE, EMBASE, and Google Scholar for all articles between April 2010 and April 2020, in accordance with the PICO acronym (participants, interventions, comparisons, outcomes). From 27 published reports, totaling 1721 cases and 1361 noncancerous control tissue samples, 26 differentially expressed microRNAs (DEmiRNAs) were identified in different International Federation of Gynecology and Obstetrics (FIGO) stages of cervical cancer development. It was identified that some of the dysregulated microRNAs were associated with specific stages of cervical cancer development. The results indicated that DEmiRNAs in different stages of cervical cancer were functionally involved in several key hallmarks of cancer, such as evading growth suppressors, enabling replicative immortality, activation of invasion and metastasis, resisting cell death, and sustained proliferative signaling. These dysregulated microRNAs could play an important role in cervical cancer’s development. Some of the stage-specific microRNAs can also be used as biomarkers for cancer classification and monitoring the progression of cervical cancer.

scholarly journals Oncogenic role of Tc17 cells in cervical cancer development

2020 ◽  
Vol 8 (1) ◽  
pp. 11-19 ◽  
Author(s):  
Zun-Sheng Zhang ◽  
Ying Gu ◽  
Bing-Gang Liu ◽  
Hong Tang ◽  
Yu Hua ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Development ◽  
Tc17 Cells ◽  
Cervical Cancer Development
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