scholarly journals Cerebral Vascular Tone Regulation: Integration and Impact of Disease

Author(s):  
Brayden Halvorson ◽  
Jefferson Frisbee
2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Hironobu Tanigami ◽  
Takayuki Okamoto ◽  
Yuichi Yasue ◽  
Motomu Shimaoka

In the neurovascular units of the central nervous system, astrocytes form extensive networks that physically and functionally connect the neuronal synapses and the cerebral vascular vessels. This astrocytic network is thought to be critically important for coupling neuronal signaling activity and energy demand with cerebral vascular tone and blood flow. To establish and maintain this elaborate network, astrocytes must precisely calibrate their perisynaptic and perivascular processes in order to sense and regulate neuronal and vascular activities, respectively. Integrins, a prominent family of cell-adhesion molecules that support astrocytic migration in the brain during developmental and normal adult stages, have been implicated in regulating the integrity of the blood brain barrier and the tripartite synapse to facilitate the formation of a functionally integrated neurovascular unit. This paper describes the significant roles that integrins and connexins play not only in regulating astrocyte migration during the developmental and adult stages of the neurovascular unit, but also in general health and in such diseases as hepatic encephalopathy.


2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Alessandro De Cassai ◽  
Sabrina Calandra ◽  
Davide Iori ◽  
Ersilia Lico ◽  
Giulio Andreatta ◽  
...  

1998 ◽  
Vol 18 (10) ◽  
pp. 1047-1063 ◽  
Author(s):  
Frank M. Faraci ◽  
Christopher G. Sobey

1995 ◽  
Vol 284 (3) ◽  
pp. 335-336
Author(s):  
Hiroyasu Hirose ◽  
Katsuhisa Ide ◽  
Tomio Sasaki ◽  
Risa Takahashi ◽  
Masahiko Kobayashi ◽  
...  

1995 ◽  
Vol 277 (1) ◽  
pp. 77-87 ◽  
Author(s):  
Hiroyasu Hirose ◽  
Katsuhisa Ide ◽  
Tomio Sasaki ◽  
Risa Takahashi ◽  
Masahiko Kobayashi ◽  
...  

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