Brain-Derived Neurotrophic Factor and Stem Cell-Based Technologies in Huntington’s Disease Therapy

Mapping Intimacies ◽

10.5772/intechopen.91226 ◽

2020 ◽

Author(s):

Irina Kerkis ◽

Joyce Macedo da Silva ◽

Cristiane Valverde Wenceslau ◽

Nicole Caroline Mambelli-Lisboa ◽

Eduardo Osorio Frare

Keyword(s):

Stem Cell ◽

Huntington's Disease ◽

Huntington’S Disease ◽

Neurotrophic Factor ◽

Brain Derived Neurotrophic Factor ◽

Disease Therapy

Download Full-text

Faculty Opinions recommendation of Expression profiling of Huntington's disease models suggests that brain-derived neurotrophic factor depletion plays a major role in striatal degeneration.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1092788.547713 ◽

2007 ◽

Author(s):

Allan Tobin

Keyword(s):

Huntington's Disease ◽

Huntington’S Disease ◽

Neurotrophic Factor ◽

Expression Profiling ◽

Brain Derived Neurotrophic Factor ◽

Disease Models ◽

Striatal Degeneration

Download Full-text

Blood level of brain-derived neurotrophic factor mRNA is progressively reduced in rodent models of Huntington's disease: Restoration by the neuroprotective compound CEP-1347

Molecular and Cellular Neuroscience ◽

10.1016/j.mcn.2008.04.012 ◽

2008 ◽

Vol 39 (1) ◽

pp. 1-7 ◽

Cited By ~ 39

Author(s):

Paola Conforti ◽

Catarina Ramos ◽

Barbara L. Apostol ◽

Danielle A. Simmons ◽

Huu Phuc Nguyen ◽

...

Keyword(s):

Huntington's Disease ◽

Huntington’S Disease ◽

Blood Level ◽

Neurotrophic Factor ◽

Brain Derived Neurotrophic Factor ◽

Rodent Models

Download Full-text

Differential Regulation of the Expression of Nerve Growth Factor, Brain-Derived Neurotrophic Factor, and Neurotrophin-3 after Excitotoxicity in a Rat Model of Huntington's Disease

Neurobiology of Disease ◽

10.1006/nbdi.1998.0211 ◽

1998 ◽

Vol 5 (5) ◽

pp. 357-364 ◽

Cited By ~ 32

Author(s):

Josep M. Canals ◽

Sònia Marco ◽

Núria Checa ◽

Alice Michels ◽

Esther Pérez-Navarro ◽

...

Keyword(s):

Nerve Growth Factor ◽

Growth Factor ◽

Huntington's Disease ◽

Huntington’S Disease ◽

Rat Model ◽

Neurotrophic Factor ◽

Brain Derived Neurotrophic Factor ◽

Differential Regulation ◽

Nerve Growth ◽

Neurotrophin 3

Download Full-text

Evaluation of Biochemical and Epigenetic Measures of Peripheral Brain-Derived Neurotrophic Factor (BDNF) as a Biomarker in Huntington’s Disease Patients

Frontiers in Molecular Neuroscience ◽

10.3389/fnmol.2019.00335 ◽

2020 ◽

Vol 12 ◽

Cited By ~ 5

Author(s):

Ashley Gutierrez ◽

Jody Corey-Bloom ◽

Elizabeth A. Thomas ◽

Paula Desplats

Keyword(s):

Huntington's Disease ◽

Huntington’S Disease ◽

Neurotrophic Factor ◽

Brain Derived Neurotrophic Factor

Download Full-text

Brain-Derived Neurotrophic Factor in Patients with Huntington's Disease

PLoS ONE ◽

10.1371/journal.pone.0022966 ◽

2011 ◽

Vol 6 (8) ◽

pp. e22966 ◽

Cited By ~ 73

Author(s):

Chiara Zuccato ◽

Manuela Marullo ◽

Barbara Vitali ◽

Alessia Tarditi ◽

Caterina Mariotti ◽

...

Keyword(s):

Huntington's Disease ◽

Huntington’S Disease ◽

Neurotrophic Factor ◽

Brain Derived Neurotrophic Factor

Download Full-text

Brain-Derived Neurotrophic Factor Regulates the Onset and Severity of Motor Dysfunction Associated with Enkephalinergic Neuronal Degeneration in Huntington's Disease

Journal of Neuroscience ◽

10.1523/jneurosci.1197-04.2004 ◽

2004 ◽

Vol 24 (35) ◽

pp. 7727-7739 ◽

Cited By ~ 224

Author(s):

J. M. Canals

Keyword(s):

Huntington's Disease ◽

Huntington’S Disease ◽

Neurotrophic Factor ◽

Neuronal Degeneration ◽

Brain Derived Neurotrophic Factor ◽

Motor Dysfunction

Download Full-text

Low brain-derived neurotrophic factor (BDNF) levels in serum of Huntington's disease patients

American Journal of Medical Genetics Part B Neuropsychiatric Genetics ◽

10.1002/ajmg.b.30501 ◽

2007 ◽

Vol 144B (4) ◽

pp. 574-577 ◽

Cited By ~ 94

Author(s):

A. Ciammola ◽

J. Sassone ◽

M. Cannella ◽

S. Calza ◽

B. Poletti ◽

...

Keyword(s):

Huntington's Disease ◽

Huntington’S Disease ◽

Neurotrophic Factor ◽

Brain Derived Neurotrophic Factor

Download Full-text

Neuroprotective mechanisms of brain-derived neurotrophic factor against 3-nitropropionic acid toxicity: therapeutic implications for Huntington's disease

Annals of the New York Academy of Sciences ◽

10.1111/j.1749-6632.2010.05628.x ◽

2010 ◽

Vol 1201 (1) ◽

pp. 8-12 ◽

Cited By ~ 22

Author(s):

Chia-Lin Wu ◽

Chi-Shin Hwang ◽

Shang-Der Chen ◽

Jiu-Haw Yin ◽

Ding-I Yang

Keyword(s):

Huntington's Disease ◽

Huntington’S Disease ◽

Neurotrophic Factor ◽

Brain Derived Neurotrophic Factor ◽

Therapeutic Implications ◽

Nitropropionic Acid ◽

Acid Toxicity ◽

3 Nitropropionic Acid

Download Full-text

Faculty Opinions recommendation of Brain-derived neurotrophic factor modulates dopaminergic deficits in a transgenic mouse model of Huntington's disease.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1016221.323235 ◽

2005 ◽

Author(s):

Allan Tobin

Keyword(s):

Mouse Model ◽

Huntington's Disease ◽

Huntington’S Disease ◽

Transgenic Mouse ◽

Neurotrophic Factor ◽

Brain Derived Neurotrophic Factor ◽

Transgenic Mouse Model

Download Full-text

Human Mesenchymal Stem Cells Genetically Engineered to Overexpress Brain-derived Neurotrophic Factor Improve Outcomes in Huntington's Disease Mouse Models

Molecular Therapy ◽

10.1038/mt.2016.12 ◽

2016 ◽

Vol 24 (5) ◽

pp. 965-977 ◽

Cited By ~ 78

Author(s):

Kari Pollock ◽

Heather Dahlenburg ◽

Haley Nelson ◽

Kyle D Fink ◽

Whitney Cary ◽

...

Keyword(s):

Stem Cells ◽

Mesenchymal Stem Cells ◽

Huntington's Disease ◽

Huntington’S Disease ◽

Mouse Models ◽

Neurotrophic Factor ◽

Human Mesenchymal Stem Cells ◽

Brain Derived Neurotrophic Factor ◽

Genetically Engineered

Download Full-text