scholarly journals Is Digital Breast Tomosynthesis Superior to Digital Mammography? A Preclinical Evaluation of Tumor Histopathological Markers Using Digital Breast Tomosynthesis

2021 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Aysegul Altunkeser ◽  
Zeynep Fatma Arslan ◽  
Mehmet Ali Eryilmaz ◽  
Muslu Kazım Korez ◽  
Zeynep Bayramoğlu
Keyword(s):  
Breast Cancer ◽  
Triple Negative ◽  
Mass Density ◽  
Digital Breast Tomosynthesis ◽  
Molecular Classification ◽  
Architectural Distortion ◽  
Ki 67 ◽  
Breast Tomosynthesis ◽  
Skin Changes ◽  
The Relationship

Background: Digital mammography (DM) and digital breast tomosynthesis (DBT) are important radiological modalities, which increase the survival of breast cancer patients. Breast cancer is a morphologically heterogeneous disease with various histopathological parameters and multiple receptors in its biological profile. Objectives: This study aimed to analyze the morphological features of invasive breast cancer on DM and DBT, to investigate the contribution of DBT to DM, to examine the association of DBT findings with pathological molecular subtypes, Bloom-Richardson grade, and Ki-67 index, and to determine the effect of breast parenchyma density on the relationship between DBT findings and hormone receptors. Patients and Methods: A total of 36 patients with malignant lesions were evaluated in this study. According to the American College of Radiology (ACR) classification, the lesion features were divided into subgroups based on DM and DBT, and the findings were compared. The relationships between DBT findings and the hormone receptor status, molecular classification, and Bloom-Richardson grade were also investigated, and the effect of density on these relationships was assessed. Results: The mean age of the patients (n = 36) was 53 years. Based on the comparison of DM and DBT findings, spiculated margins, mass density, architectural distortion, and microcalcifications were significantly more frequent in DBT. Lesions with indistinct margins on DM were observed as mass lesions with spiculated margins on DBT (P < 0.001). Regarding the relationship between DBT findings and hormone receptor status and Ki-67 proliferation index, in PR-positive patients, an irregular tumor shape was more common (89.7%). In PR-negative patients, skin changes and nipple retraction were more frequently seen (P = 0.03 for skin changes, and P = 0.049 for nipple retraction). Regarding the association between Bloom-Richardson grade and DBT findings, tumors with a higher grade were more likely to be associated with a high tumor density (P = 0.032). Also, considering the relationship between molecular classification and DBT findings, skin changes and nipple retraction were significantly more frequent in triple-negative masses compared to other subtypes (P = 0.011 for skin changes and P = 0.016 for nipple retraction). Conclusions: DBT is superior to DM, as it reveals the lesion margins, density, and architectural distortion more accurately. The majority of PR-positive tumors were irregular, while most PR-negative cases were round. The mass density also increased as the tumor grade increased. Skin change and nipple retraction were frequently seen in triple-negative tumors compared to other subtypes. Therefore, DBT is a promising diagnostic tool for showing molecular subtypes in dense breasts.

scholarly journals The Adjunctive Digital Breast Tomosynthesis in Diagnosis of Breast Cancer

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Tsung-Lung Yang ◽  
Huei-Lung Liang ◽  
Chen-Pin Chou ◽  
Jer-Shyung Huang ◽  
Huay-Ben Pan
Keyword(s):  
Breast Cancer ◽  
Diagnostic Performance ◽  
Digital Breast Tomosynthesis ◽  
Subjective Assessment ◽  
Architectural Distortion ◽  
Breast Cancers ◽  
Chi Square ◽  
Breast Tomosynthesis ◽  
Chi Square Test ◽  
Mass Lesions

Purpose. To compare the diagnostic performance of digital breast tomosynthesis (DBT) and digital mammography (DM) for breast cancers.Materials and Methods. Fifty-seven female patients with pathologically proved breast cancer were enrolled. Three readers gave a subjective assessment superiority of the index lesions (mass, focal asymmetry, architectural distortion, or calcifications) and a forced BIRADS score, based on DM reading alone and with additional DBT information. The relevance between BIRADS category and index lesions of breast cancer was compared by chi-square test.Result. A total of 59 breast cancers were reviewed, including 17 (28.8%) mass lesions, 12 (20.3%) focal asymmetry/density, 6 (10.2%) architecture distortion, 23 (39.0%) calcifications, and 1 (1.7%) intracystic tumor. Combo DBT was perceived to be more informative in 58.8% mass lesions, 83.3% density, 94.4% architecture distortion, and only 11.6% calcifications. As to the forced BIRADS score, 84.4% BIRADS 0 on DM was upgraded to BIRADS 4 or 5 on DBT, whereas only 27.3% BIRADS 4A on DM was upgraded on DBT, as BIRADS 4A lesions were mostly calcifications. A significantPvalue (<0.001) between the BIRADS category and index lesions was noted.Conclusion. Adjunctive DBT gives exquisite information for mass lesion, focal asymmetry, and/or architecture distortion to improve the diagnostic performance in mammography.

scholarly journals Breast cancer Ki-67 expression prediction by digital breast tomosynthesis radiomics features

2019 ◽  
Vol 3 (1) ◽  
Author(s):  
Alberto Stefano Tagliafico ◽  
Bianca Bignotti ◽  
Federica Rossi ◽  
Joao Matos ◽  
Massimo Calabrese ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Digital Breast Tomosynthesis ◽  
Ki 67 ◽  
Breast Tomosynthesis

The role of Ki-67 in molecular breast cancer classification.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. 583-583
Author(s):  
George Stathopoulos ◽  
Nikolaos Malamos ◽  
Christos Markopoulos ◽  
Athanasios Polychronis ◽  
Sotirios Rigatos ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Triple Negative ◽  
Progesterone Receptors ◽  
Molecular Classification ◽  
Breast Cancer Patients ◽  
Luminal A ◽  
Ki 67 ◽  
Luminal B ◽  
Her 2

583 Background: The Ki-67 antigen was identified the involvement in early steps of polymerase I-dependent ribosomal RNA synthesis. Although it seems that the protein has an important function in cell division, its exact role is still obscure and there is little published work on its overall function. The aim of the present study is to evaluate the contribution of Ki-67 level in respect of tumor recurrence in molecular classified groups of breast cancer patients. Methods: Breast cancer tumor samples were examined for histological confirmation and for estrogen and progesterone receptors, c-erb-B2 expression, proliferation with Grade and Ki-67. Ki-67 was divided in percentage levels, up to 20 and higher than 20%. Immunohistochemistry and Fluorescence in situ hybridization is described for the results of ER, PR, c-erb-B2, Ki-67 biomarkers. Formaldehyde – fixed breast samples were paraffin wax embedded and processed for paraffin sections. The primary antibodies used were: The monoclinal antibody ID5 (M7047, Dakocytomation, Carpinteria, CA) for the detection of ER, the monoclonal anti-PR antibody 636 was used. For the detection of Ki-67 we used monoclonal mouse anti-human Ki-67 MIB-1. The patients molecular classification was Luminal A, Luminal B, Her-2 subtype and basal cell (triple negative). Results: 847 breast cancer patients were recruited. 291 were group as Luminal A, 228 as Luminal B, 221 Her-2 subtype and 107 triple negative. Follow-up was from 3 years to 15 years since diagnosis. It was found that in Luminal A patients, none had Ki-67 higher than 20% and the recurrence was in 10.65%. In Luminal B, the Ki-67 was higher than 20% in 61% of the patients and recurrence 23.68%. In Her-2 subtype >20% Ki-67 was 78.94%, recurrence 17.19%. In triple negative > 20% Ki-67 was in 68.75% and recurrence in 29.90% of the patients. Conclusions: The data presented here indicate that Ki-67 level may be considered as one of valuable biomarkers in breast cancer patients process and recurrence.

DETECTION OF BREAST CANCERS REPRESENTED AS ARCHITECTURAL DISTORTION: A COMPARISON OF FULL-FIELD DIGITAL MAMMOGRAPHY AND DIGITAL BREAST TOMOSYNTHESIS

2021 ◽  
Vol 74 (7) ◽  
pp. 1674-1679
Author(s):  
Tetiana M. Babkina ◽  
Andrii V. Gurando ◽  
Tetiana M. Kozarenko ◽  
Viacheslav R. Gurando ◽  
Vadim V. Telniy ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Digital Mammography ◽  
Digital Breast Tomosynthesis ◽  
Architectural Distortion ◽  
Breast Cancers ◽  
Breast Tomosynthesis ◽  
Full Field ◽  
Full Field Digital Mammography ◽  
Ductal Hyperplasia ◽  
History Of

The aim: The aim of our study was to determine if digital breast tomosynthesis improves breast cancer detection associated with architectural distortion in comparison with full-field digital mammography in the absence of appropriate history of trauma or surgery. Materials and methods: The overall rate of breast cancer involvement for the 34 patients with architectural distortion was 15 cases (44,1%) (invasive breast cancers, n=12 (36,4%); ductal cancer in situ, n= 3 (8,8%)) other findings associated with architectural distortion were high-risk lesions and benign findings (radial scar, n=5 (14,7%); sclerosing adenosis, n=9 (26,5%); typical lobular hyperplasia, n=3 (8,8%); typical ductal hyperplasia, n=2 cases (5,9%)). Results: Overall of 17/34 (50.0%) architectural distortions were identified at digital breast tomosynthesis that were missed at full-field digital mammography what was statistically significant difference ([95% CI, 2.56–7.45]; p=0.00001). Analysis of the results showed that sensitivity of full-field digital mammography for digital breast tomosynthesis detected breast cancers associated with architectural distortion was 53.3% [95% CI, 26.59% to 78.73%] and specificity was 52.63% [95% CI, 28.86% to 75.55%]. Conclusions: Our study suggests that digital breast tomosynthesis detects more breast cancers represented as architectural distortion which are occult on full-field digital mammography. Presence of microcalcifications within architectural distortion, in the absence of appropriate history of trauma or surgery, has a high likelihood of malignancy and obligatorily requires biopsy.

scholarly journals HUBUNGAN EKSPRESI Ki-67 DENGAN KARAKTERISTIK HISTOPATOLOGIK PADA KANKER PAYUDARA TRIPEL NEGATIF

2015 ◽  
Vol 38 (3) ◽  
pp. 165
Author(s):  
Aswiyanti Asri ◽  
Pamelia Mayorita ◽  
Daan Khambri
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Lymphovascular Invasion ◽  
Triple Negative ◽  
Response To Therapy ◽  
Chi Square ◽  
Ki 67 ◽  
Histopathological Grade ◽  
Chi Square Test ◽  
The Relationship

AbstrakKanker payudara triple negative mempunyai prognosis paling buruk. Ki-67, derajat diferensiasi dan invasi limfovaskular (LVI) adalah parameter prognostik patomolekuler, dimana Ki-67 juga dipakai sebagai prediktor respon terapi. Penelitian ini bertujuan untuk mengetahui hubungan derajat diferensiasi dan LVI dengan ekspresi Ki-67 pada kanker payudara tripel negatif. Sembilan belas kasus kanker payudara tripel negatif dikumpulkan dan direview ulang derajat diferensiasi dan LVI. Hasil pemeriksaan Ki-67 dikelompokkan dimana ≤10 % sampai 29 % ekspresi rendah-sedang; dan >30% ekspresi tinggi. Hubungan antara ekspresi Ki-67 dengan derajat diferensiasi dan invasi limfovaskular dianalisis menggunakan Chi Square. Dari 19 kasus kanker payudara tripel negatif, 52,6 % kasus mempunyai derajat diferensiasi tinggi dan sisanya derajat diferensiasi rendah. Invasi limfovaskular ditemukan positif pada 68,4% kasus. Ekspresi Ki-67 yang tinggi hanya ditemukan pada 1 kasus. Uji statistik antara ekspresi Ki-67 dengan derajat diferensiasi maupun dengan invasi limfovaskular tidak ditemukan hubungan yang bermakna. Tidak ditemukan korelasi antara ekspresi Ki-67 dengan derajat diferensiasi dan invasi limfovaskular pada kanker payudara tripel negatif.AbstractTriple negative breast cancer is one of the breast cancer with poorest prognosis. Ki- 67, grade and lymphovascular invasion are the prognostic pathomolecular parameter, and also used as a predictor of response to therapy. The objective of this study was to identify the relationship between Ki-67 expression with grade and lymphovascular invasion in triple negative breast cancer. We found 19 cases of triple negative breast cancer,and performed slide review for grade and lymphovascular invasion. The results of Ki-67 expression were classifiy as low – intermediate (< 10 % - 29%) and high (> 30%). We use Chi Square test to assest the relationship between variables. Of 19 triple negative breast cancer cases, 52,6 % of cases were found to have high histopathological grade. Positive lymphovascular invasion was seen in 68,4% cases. Only one case was found with high expression of Ki-67. There were no correlation between Ki-67 expression with histopathological grade and lymphovascular invasion on triple negative breast cancer. There were no significant relationship between Ki-67 expression with grade and lymphovascular invasion on triple negative breast cancer.

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