Nasal Natural Killer Lymphoma Associated With Epstein-Barr Virus in a Patient Infected With Human Immunodeficiency Virus

2001 ◽  
Vol 125 (5) ◽  
pp. 660-662 ◽  
Author(s):  
Danielle Canioni ◽  
Bertrand Arnulf ◽  
Marianne Asso-Bonnet ◽  
Martine Raphael ◽  
Nicole Brousse
Keyword(s):  
Human Immunodeficiency Virus ◽  
Natural Killer ◽  
Epstein Barr Virus ◽  
Denaturing Gradient Gel Electrophoresis ◽  
Nk Cell ◽  
Cell Lymphoma ◽  
Barr Virus ◽  
First Case ◽  
Immunodeficiency Virus ◽  
Epstein Barr

Abstract Nasal natural killer (NK) lymphoma associated with Epstein-Barr virus (EBV) is a rare lymphoma that has not yet been reported in patients with human immunodeficiency virus (HIV). This report describes the first case, to our knowledge, of nasal NK cell lymphoma in an HIV-positive patient. A 50-year-old African man presented with an obstructive nasopharyngeal tumor, leading to the diagnosis of HIV infection. Nasal biopsy specimens showed NK cell lymphoma, confirmed on nasal tissues by morphologic, immunohistochemical, and polymerase chain reaction studies using a denaturing gradient gel electrophoresis technique that showed no T-cell receptor γ rearrangement. The EBV was detected by in situ hybridization. The patient received chemotherapy but died from infection. To our knowledge, this is the first reported case of nasal NK cell lymphoma associated with EBV in an HIV patient. Involvement of EBV in HIV non–B-cell lymphomas may represent a further manifestation of opportunistic EBV infection arising in these patients.

scholarly journals The First Case of Concomitant Mycobacterium genavense lymphadenitis and EBV-positive lymphoproliferative disorder

2020 ◽  
Vol 12 (1) ◽  
pp. e2020035
Author(s):  
Yusuke Ito ◽  
Kensuke Takaoka ◽  
Kazuhiro Toyama ◽  
Yoshitaka Wakabayashi ◽  
Aya Shinozaki-Ushiku ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Lymph Node ◽  
Lymphoproliferative Disorder ◽  
Epstein Barr Virus ◽  
Type Iii ◽  
Barr Virus ◽  
First Case ◽  
Immunodeficiency Virus ◽  
Mycobacterium Genavense ◽  
Epstein Barr

This is the first case of concurrent Mycobacterium genavense lymphadenitis and Epstein-Barr virus (EBV)-positive lymphoproliferative disorder (LPD) in the same lymph node with no immunocompromised history. M. genavense infection is a rare opportunistic infection mainly for human immunodeficiency virus (HIV)-infected patients. Although no immunodeficiency was detected in our patient, our case indicates that the immunodeficiency in the background of EBV latency type III and the immunosuppression by malignant lymphoma itself might induce the M. genavense lymphadenitis. This case highly alerts clinicians the immunosuppressive state of EBV-positive LPD with latency type III even if any serological immunodeficient factors are not detected.

NK/T-Cell Lymphoma Associated with Epstein-Barr Virus in a Patient Infected with Human Immunodeficiency Virus: An Autopsy Case

2004 ◽  
Vol 79 (5) ◽  
pp. 480-483 ◽  
Author(s):  
Sang Cheul Oh ◽  
Chul Won Choi ◽  
Byung Soo Kim ◽  
Sang Won Shin ◽  
Yeul Hong Kim ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
T Cell ◽  
Epstein Barr Virus ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Autopsy Case ◽  
Barr Virus ◽  
Immunodeficiency Virus ◽  
Nk T Cell ◽  
Epstein Barr

scholarly journals Epstein-Barr virus-related oral T-cell lymphoma associated with human immunodeficiency virus immunosuppression

Blood ◽  
1993 ◽  
Vol 81 (12) ◽  
pp. 3350-3356 ◽  
Author(s):  
JA Thomas ◽  
F Cotter ◽  
AM Hanby ◽  
LQ Long ◽  
PR Morgan ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
T Cell ◽  
Epstein Barr Virus ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Barr Virus ◽  
Ebv Infection ◽  
Hairy Leukoplakia ◽  
Immunodeficiency Virus ◽  
Epstein Barr

Epstein-Barr virus (EBV) is generally held to infect B cells and epithelial cells, although there are now reports of EBV infection in normal T cells and neoplastic T-cell diseases. In patients with human immunodeficiency virus (HIV) infection, EBV is associated with the benign epithelial lesion, hairy leukoplakia, and has been reported in up to 80% of acquired immunodeficiency syndrome (AIDS)-related B-cell lymphoma. This study shows the presence of EBV in malignant oral T-cell lymphoma in three AIDS patients, two of whom had concurrent manifestation of hairy leukoplakia. The T-cell lineage of the tumor cells was determined by positive immunophenotyping for T-cell markers and lack of B-cell or nonhematopoietic (cytokeratin) determinants. All tumors contained monoclonal T-cell populations shown by polymerase chain reaction, which showed amplification of T-cell receptor gamma chain DNA without evidence of Ig heavy chain gene rearrangement. Furthermore, these lesions showed the presence of EBV DNA and expression of EBV latent gene products in the tumor cells. EBV involvement in AIDS-related T-cell lymphoma has not been widely reported and may represent a further manifestation of opportunistic EBV infection arising in the HIV-immunocompromised host.

scholarly journals Epstein-Barr virus-related oral T-cell lymphoma associated with human immunodeficiency virus immunosuppression

Blood ◽  
1993 ◽  
Vol 81 (12) ◽  
pp. 3350-3356 ◽  
Author(s):  
JA Thomas ◽  
F Cotter ◽  
AM Hanby ◽  
LQ Long ◽  
PR Morgan ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
T Cell ◽  
Epstein Barr Virus ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Barr Virus ◽  
Ebv Infection ◽  
Hairy Leukoplakia ◽  
Immunodeficiency Virus ◽  
Epstein Barr

Abstract Epstein-Barr virus (EBV) is generally held to infect B cells and epithelial cells, although there are now reports of EBV infection in normal T cells and neoplastic T-cell diseases. In patients with human immunodeficiency virus (HIV) infection, EBV is associated with the benign epithelial lesion, hairy leukoplakia, and has been reported in up to 80% of acquired immunodeficiency syndrome (AIDS)-related B-cell lymphoma. This study shows the presence of EBV in malignant oral T-cell lymphoma in three AIDS patients, two of whom had concurrent manifestation of hairy leukoplakia. The T-cell lineage of the tumor cells was determined by positive immunophenotyping for T-cell markers and lack of B-cell or nonhematopoietic (cytokeratin) determinants. All tumors contained monoclonal T-cell populations shown by polymerase chain reaction, which showed amplification of T-cell receptor gamma chain DNA without evidence of Ig heavy chain gene rearrangement. Furthermore, these lesions showed the presence of EBV DNA and expression of EBV latent gene products in the tumor cells. EBV involvement in AIDS-related T-cell lymphoma has not been widely reported and may represent a further manifestation of opportunistic EBV infection arising in the HIV-immunocompromised host.

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