Large Cell Neuroendocrine Carcinoma of the Ampulla of Vater

2003 ◽  
Vol 127 (2) ◽  
pp. 221-223 ◽  
Author(s):  
Alberto Cavazza ◽  
Marco Gallo ◽  
Roberto Valcavi ◽  
Loredana De Marco ◽  
Giorgio Gardini
Keyword(s):  
Mitotic Index ◽  
Neuroendocrine Carcinoma ◽  
Poor Prognosis ◽  
Neuron Specific Enolase ◽  
Large Cell ◽  
Ampulla Of Vater ◽  
Large Cell Neuroendocrine Carcinoma ◽  
Neoplastic Cells

Abstract We report a large cell neuroendocrine carcinoma arising in the ampulla of Vater. The patient, a 74-year-old woman, presented with a 3-cm ulcerated mass located in the ampullary region. She died of disease 8 months after surgery. Microscopically, the tumor was extensively necrotic. It was composed of islands and trabeculae irregularly infiltrating the muscular wall of the duodenum. Neoplastic cells were large and had a high mitotic index. Immunohistochemically, they expressed cytokeratin, chromogranin, synaptophysin, and neuron-specific enolase. Large cell neuroendocrine carcinoma is very rare in the ampulla of Vater, and it shares with its more common pulmonary counterpart the same morphology and probably the same poor prognosis.

scholarly journals Primary Large-Cell Neuroendocrine Carcinoma of the Breast Occurring in a Pre-Menopausal Woman

Breast Care ◽  
2015 ◽  
Vol 10 (4) ◽  
pp. 281-283 ◽  
Author(s):  
Noriko Yoshimura ◽  
Tatsunari Sasada ◽  
Shuji Yonehara
Keyword(s):  
Lymph Node ◽  
Neuroendocrine Carcinoma ◽  
English Literature ◽  
Neuron Specific Enolase ◽  
Large Cell ◽  
Lymph Node Biopsy ◽  
Large Cell Neuroendocrine Carcinoma ◽  
Menopausal Woman ◽  
Axillary Lymph ◽  
Carcinoma Of The Breast

Background: Primary large-cell neuroendocrine carcinoma of the breast (LCNEC-breast) in pre-menopausal women is extremely rare. Case report: A 34-year-old woman presented with a mass in the left breast that was diagnosed as neuroendocrine carcinoma by needle biopsy. Computed tomography revealed no lymph node swelling or distant organ metastasis. Left mastectomy and sentinel lymph node biopsy were performed and metastasis to the axial lymph node was detected. Left axillary lymph node dissection was performed and histopathological and immunohistochemical examination revealed that the tumor was an LCNEC-breast, which was 6.0 cm in size and positive for the neuroendocrine markers (neuron-specific enolase, chromogranin A, and synaptophysin). The tumor cells were hormone-receptor positive and HER2 negative. The patient refused any adjuvant hormonal therapy, chemotherapy or radiotherapy. She has been followed up for 4 years without medication, and no recurrence has been noted. Conclusion: We present a case of LCNEC-breast in a 34-year-old woman. Our case represents the youngest woman with LCNEC-breast reported in the English literature.

scholarly journals Advanced Composite of Large Cell Neuroendocrine Carcinoma and Squamous Cell Carcinoma: A Case Report of Uterine Cervical Cancer in a Virgin Woman

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
Ryusuke Murakami ◽  
Iemasa Kou ◽  
Kenjiro Date ◽  
Hirofumi Nakayama
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Tumor Cells ◽  
Neuroendocrine Carcinoma ◽  
Squamous Cell ◽  
Uterine Cervix ◽  
Neuron Specific Enolase ◽  
Large Cell ◽  
Large Cell Neuroendocrine Carcinoma ◽  
Hpv Test

Large cell neuroendocrine carcinoma (LCNEC) of the uterine cervix is very rare and aggressive. The prognosis is very poor despite multimodal treatment. We report a virgin woman with FIGO stage 4b LCNEC of uterine cervix coexisting with squamous cell carcinoma. An early thirties virgin woman presented with 2-month history of abdominal pain. A chest X-ray showed multiple lung metastatic tumors. A vaginal smear showed malignant cells, and a biopsy specimen had features of LCNEC. The tumor showed trabecular patterns. Tumor cells possessed a moderate amount of cytoplasm, prominent nucleoli, and large nuclei. The tumor cells are stained positive for synaptophysin, chromogranin A, and neuron specific enolase (NSE). The invasive tumor cells in connection with cervical squamous epithelium were focally positive for 34bE12. We made a diagnosis of composite LCNEC and nonkeratinizing squamous cell carcinoma. High-risk HPV test was negative with hybridized captured method 2.

scholarly journals Large Cell Neuroendocrine Carcinoma of the Ampulla of Vater—Report of a Case—

2018 ◽  
Vol 79 (5) ◽  
pp. 1007-1015
Author(s):  
Shingo SEO ◽  
Akira NAKASHIMA ◽  
Hidenori MUKAIDA ◽  
Mayumi KANEKO ◽  
Naoki HIRABAYASHI
Keyword(s):  
Neuroendocrine Carcinoma ◽  
Large Cell ◽  
Ampulla Of Vater ◽  
Large Cell Neuroendocrine Carcinoma

scholarly journals Long lasting octreotide LAR therapy in large cell neuroendocrine carcinoma (LCNEC) of the lung

2015 ◽  
Vol 4 (1S) ◽  
pp. 15-18
Author(s):  
Alfredo Butera
Keyword(s):  
Neuroendocrine Carcinoma ◽  
Poor Prognosis ◽  
Large Cell ◽  
Mechanisms Of Action ◽  
Large Cell Neuroendocrine Carcinoma ◽  
Optimal Dosage ◽  
Biological Behaviour ◽  
Octreotide Lar ◽  
Individual Tumour

In this article we report a case of a patient with large cell neuroendocrine carcinoma (LCNEC) of the lung. Patients with LCNEC usually have poor prognosis and the benefit of adjuvant chemotherapy for these patients has not been fully established. This case suggests that octreotide LAR, a somatostatine analogue (SSA), can be useful in the treatment of neuroendocrine carcinoma also as maintenance therapy in association with chemotherapy. Further studies, regarding individual tumour biological behaviour and SSAs optimal dosage, could be useful to optimise treatment and to add new insights into the mechanisms of action and the role of SSAs in the therapy of NETs.

Poor prognosis of ovarian cancer with large cell neuroendocrine carcinoma: Case report and review of published works

2013 ◽  
Vol 40 (3) ◽  
pp. 869-872 ◽  
Author(s):  
Kayo Asada ◽  
Kei Kawana ◽  
Shinichi Teshima ◽  
Ako Saito ◽  
Masakiyo Kawabata ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Case Report ◽  
Neuroendocrine Carcinoma ◽  
Poor Prognosis ◽  
Large Cell ◽  
Large Cell Neuroendocrine Carcinoma
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