scholarly journals Review of the pathophysiology, diagnosis, and therapy of vulvar leiomyoma, a rare gynecological tumor

2017 ◽  
Vol 46 (2) ◽  
pp. 663-674 ◽  
Author(s):  
Chao Sun ◽  
Junkai Zou ◽  
Qing Wang ◽  
Qi Wang ◽  
Lu Han ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Smooth Muscle ◽  
English Language ◽  
External Genitalia ◽  
Surgical Excision ◽  
Smooth Muscle Tumor ◽  
Final Diagnosis ◽  
Diagnosis And Therapy ◽  
Long Term Follow Up ◽  
Muscle Tumor

The objective of this article is to discuss the pathophysiology, diagnosis, differential diagnosis, and therapy of vulvar leiomyoma. We performed a review of all English-language reports of vulvar leiomyoma published in PubMed from 1978 to 2015 using the following search terms: “vulval leiomyoma,” “vulvar leiomyoma,” “vulval smooth muscle tumor,” and “external genitalia smooth muscle tumor.” Vulvar leiomyomas, which are rare benign monoclonal tumors, most commonly occur in the fourth and fifth decades of life. The genetics of vulvar leiomyoma remain undefined. Three principal histological patterns have been identified: spindled, epithelioid, and myxoid. Imaging tests such as ultrasound, endoscopic ultrasound, and magnetic resonance imaging are used in diagnosis. Surgical excision is the only curative treatment for vulvar leiomyomas. Establishment of a full differential diagnosis list and correct final diagnosis before surgery are essential for optimal clinical management. Although recurrence of vulvar leiomyoma is extremely rare, long-term follow-up of all cases is advisable.

scholarly journals Multiple Oral Leiomyomas in an Infant: A Rare Case

2012 ◽  
Vol 2012 ◽  
pp. 1-3 ◽  
Author(s):  
Efraín Alvarez ◽  
María P. Laberry ◽  
Carlos M. Ardila
Keyword(s):  
Smooth Muscle ◽  
Gastrointestinal Tract ◽  
Oral Cavity ◽  
Rare Case ◽  
Surgical Excision ◽  
Smooth Muscle Tumor ◽  
Review Of The Literature ◽  
Histological Studies ◽  
Floor Of The Mouth ◽  
Muscle Tumor

Oral leiomyoma is a benign smooth muscle tumor that occurs most frequently in the uterine myometrium, gastrointestinal tract, and skin. Incidence in the oral cavity is considered uncommon. Most cases are reported in adults, with very few cases described in children. A rare case of multiple leiomyomas localized on the tongue, cheek, and floor of the mouth of an 8-month-old baby is reported. The diagnosis of leiomyoma in the oral cavity is mainly determined by histological studies; however, immunohistochemical tests are recommended in order to differentiate from other tumors. Surgical excision of the lesion appears to be the best treatment option. A review of the literature did not reveal any previously reported case of multiple oral leiomyomas.

scholarly journals Colon Leiomyoma Diagnosed and Treated with Endoscopy

2020 ◽  
Vol 95 (5) ◽  
pp. 336-339
Author(s):  
Ha Young Oh
Keyword(s):  
Differential Diagnosis ◽  
Smooth Muscle ◽  
Small Intestine ◽  
Digestive Tract ◽  
Endoscopic Mucosal Resection ◽  
Smooth Muscle Tumor ◽  
Endoscopic Examination ◽  
Colon Polyps ◽  
Subepithelial Tumors ◽  
Muscle Tumor

Leiomyoma is a benign smooth muscle tumor that may occur throughout the entire digestive tract. It occurs more frequently in the stomach and the small intestine, but is rarely seen in the large intestine. Here, we report two cases of colon leiomyoma mimicking the appearance of colon polyps that were found incidentally. They were simultaneously diagnosed and treated by endoscopic mucosal resection. Careful and thorough endoscopic examination is required for differential diagnosis of polyps that may actually be subepithelial tumors.

Smooth Muscle Tumor of the Pleura

2000 ◽  
Vol 124 (11) ◽  
pp. 1688-1692 ◽  
Author(s):  
Daniela M. Proca ◽  
Patrick Ross ◽  
Jerry Pratt ◽  
Wendy L. Frankel
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Tumor ◽  
Pectoral Muscle ◽  
Parietal Pleura ◽  
Smooth Muscle Tumors ◽  
Long Term Follow Up ◽  
Pleural Neoplasm ◽  
Muscle Tumor

Abstract Smooth muscle tumors of the serosal membranes are extremely rare and have received little attention in the literature. To the best of our knowledge, only 1 published series of 5 pleural smooth muscle neoplasms has been published to date. We describe a primary pleural neoplasm with smooth muscle differentiation documented by light microscopy, immunohistochemistry, and electron microscopy. This tumor originated in the parietal pleura in a 32-year-old white man and was diagnosed incidentally by chest radiography; the diagnosis was confirmed by magnetic resonance imaging and biopsy. Four years later, the tumor was noted to have increased in size and disseminated into the chest wall as a separate circumscribed mass located in the pectoral muscle. Both masses were resected and diagnosed as smooth muscle tumors. We conclude that smooth muscle tumor of the pleura is a well-defined entity with a low, but definite malignant potential; therefore, we recommend complete resection and long-term follow-up for all patients.

Solitary fibroleiomyomatous hamartoma of the lung in a patient without a pre-existing smooth-muscle tumor

2001 ◽  
Vol 51 (8) ◽  
pp. 661-665 ◽  
Author(s):  
Hiroshi Itoh ◽  
Masayuki Yanagi ◽  
Tetsuro Setoyama ◽  
Kazusada Shirao ◽  
Shigehisa Yanagi ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Tumor ◽  
Muscle Tumor

Gastrointestinal Stromal Tumor Presenting as a Recurrent Vaginal Mass

2004 ◽  
Vol 128 (12) ◽  
pp. 1442-1444 ◽  
Author(s):  
Katherine M. Ceballos ◽  
Julie-Ann Francis ◽  
John L. Mazurka
Keyword(s):  
Differential Diagnosis ◽  
Smooth Muscle ◽  
Gastrointestinal Stromal Tumor ◽  
Interstitial Cell ◽  
Smooth Muscle Tumor ◽  
Stromal Tumor ◽  
Mesenchymal Neoplasms ◽  
Smooth Muscle Neoplasm ◽  
Rectal Involvement ◽  
Vaginal Smooth Muscle

Abstract Gastrointestinal stromal tumors are CD117 (c-Kit)–positive mesenchymal neoplasms with histologic and ultrastructural features of the interstitial cell of Cajal. While tumors outside of the gastrointestinal tract have been described, to our knowledge the case we present is the first such case in the vagina. We describe a 75-year-old woman with a recurrent vaginal gastrointestinal stromal tumor without apparent rectal involvement. This tumor was characterized by short intersecting fascicles of spindled cells, focal necrosis, and 12 to 15 mitoses per 50 high-power fields. Immunohistochemistry revealed diffuse cytoplasmic positivity for CD117 (c-Kit), CD34, vimentin, and h-caldesmon. Tumor cells were negative for S100, desmin, actin, and CAM 5.2. The differential diagnosis in this case included a vaginal smooth muscle tumor. While histologically similar to a smooth muscle neoplasm, the immunohistochemical profile ruled out smooth muscle differentiation. Gastrointestinal stromal tumor should be considered in the differential diagnosis of vaginal mesenchymal neoplasms.

scholarly journals Multifocal EBV-Associated and CMV-Correlated Post-Transplant Smooth Muscle Tumor: A Case After Liver Transplantation

2021 ◽  
Author(s):  
Mohammad Hossein Anbardar ◽  
Neda Soleimani ◽  
Dornaz Safavi ◽  
Ahad Eshraghian ◽  
Abbas Ayoub
Keyword(s):  
Liver Transplantation ◽  
Smooth Muscle ◽  
Spindle Cell ◽  
Smooth Muscle Tumor ◽  
Cmv Infection ◽  
Post Transplant ◽  
Smooth Muscle Tumors ◽  
Microscopic Evaluation ◽  
Paraffin Block ◽  
Muscle Tumor

Abstract IntroductionImmunodeficient patients, including the recipients of solid organs, exhibit an increase in the incidence of neoplasms. Post-transplant smooth muscle tumor (PTSMT) is a distinct and infrequent entity of these groups of neoplasms. Epstein–Barr virus (EBV) is considered to be involved in the etiology of this neoplasm.Case reportA 28-year-old man who underwent liver transplantation presented with abdominal pain and diarrhea for several months. He had a history of resistant systemic cytomegalovirus (CMV) infection after transplantation. On physical examination, he had mild abdominal tenderness. Spiral chest and abdominopelvic CT scan with contrast showed a liver lesion with ring enhancement; furthermore, it showed a solid lesion in the spleen and multiple small lesions in lower lobes of both lungs. Colonoscopy revealed multiple small raised polypoid lesions throughout the rectum and colon. Microscopic evaluation of colon mucosa biopsy using IHC study was in favor of spindle cell neoplasm with high proliferative index. He underwent a right hemicolectomy. A microscopic study showed spindle cell proliferation with mild atypia and a mild increase in mitotic rate without any necrosis, with features of smooth muscle tumor. Trucut biopsy of liver mass was also in favor of smooth muscle tumor. According to transplantation history and considering the possibility of EBV-associated smooth muscle tumor, EBV encoded RNA (EBER) chromogenic in-situ hybridization (CISH) study on paraffin block of colon lesions was requested, which demonstrated EBV RNA in tumor cell nuclei and immunoblasts of the adjacent lymph node, suggesting EBV-associated smooth muscle tumor. In addition, PCR for CMV was requested on paraffin block of the colon lesions, which also showed a positive result. PCR for EBV and CMV viremia were negative. The dosage of immunosuppressive agents was reduced, and currently, he is being followed, with slow expansion in the size of the lesions.Conclusion Although the incidence of post-transplant smooth muscle tumors (PTSMTs) is low, it should be remained in the differential diagnosis in post-transplantation patients, especially dealing with multifocal tumors. As strong stimulant for smooth muscle tumors, close follow-up and screening for EBV and CMV infection and early treatment at the time of diagnosis are recommended to avoid these virus-induced tumors.

Sign in / Sign up

Export Citation Format

Share Document