In this chapter, substantive Mooreanism, according to which one does know that one is not a brain in a vat, is explained, and two main varieties of it are distinguished. Contextualist Mooreanism, (a) on which it is only claimed that one knows that one is not a brain in a vat according to ordinary standards for knowledge, and (b) on which one seeks to defeat bold skepticism (according to which one doesn’t know simple, seemingly obvious truths about the external world, even by ordinary standards for knowledge), is contrasted with Putnam-style responses, on which one seeks to refute the skeptic, utilizing semantic externalism. Problems with the Putnam-style attempt to refute skepticism are identified, and then, more radically, it is argued that in important ways, such a refutation of skepticism would not have provided an adequate response to skepticism even if it could have been accomplished.