49. Spectrum Analysis of CT-Images : Comparison with Bone Mineral Density by Quantitative-CT

Abstract Despite the fact that bone mineral density (BMD) is an important fracture risk predictor in human medicine, studies in equine orthopedic research are still lacking. We hypothesized that BMD correlates with bone failure and fatigue fractures of this bone. Thus, the objectives of this study were to measure the structural and mechanical properties of the proximal phalanx with dual energy X-ray absorptiometry (DXA), to correlate the data obtained from DXA and computer tomography (CT) measurements to those obtained by loading pressure examination and to establish representative region of interest (ROI) for in vitro BMD measurements of the equine proximal phalanx for predicting bone failure force. DXA was used to measure the whole bone BMD and additional three ROI sites in 14 equine proximal phalanges. Following evaluation of the bone density, whole bone, cortical width and area in the mid-diaphyseal plane were measured on CT images. Bones were broken using a manually controlled universal bone crusher to measure bone failure force and reevaluated for the site of fractures on follow-up CT images. Compressive load was applied at a constant displacement rate of 2 mm/min until failure, defined as the first clear drop in the load measurement. The lowest BMD was measured at the trabecular region (mean ± SD: 1.52 ± 0.12 g/cm2; median: 1.48 g/cm2; range: 1.38-1.83 g/cm2). There was a significant positive linear correlation between trabelcular BMD and the breaking strength (P=0.023, r=0.62). The trabecular region of the proximal phalanx appears to be the only significant indicator of failure of strength in vitro. This finding should be reassessed to further reveal the prognostic value of trabecular BMD in an in vivo fracture risk model.

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Quantitative CT Detects Undiagnosed Low Bone Mineral Density in Oncologic Patients Imaged With 18F-FDG PET/CT

Clinical Nuclear Medicine ◽

10.1097/rlu.0000000000003416 ◽

2021 ◽

Vol 46 (1) ◽

pp. 8-15

Author(s):

Fernando U. Kay ◽

Vinh Ho ◽

Edmund B. Dosunmu ◽

Avneesh Chhabra ◽

Keenan Brown ◽

...

Keyword(s):

Bone Mineral Density ◽

Bone Mineral ◽

Fdg Pet ◽

Mineral Density ◽

Quantitative Ct ◽

Low Bone Mineral Density ◽

Pet Ct ◽

Oncologic Patients ◽

18F Fdg ◽

Fdg Pet Ct

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Correlation of insertion torques with bone mineral density from dental quantitative CT in the mandible

Clinical Oral Implants Research ◽

10.1034/j.1600-0501.2003.00932.x ◽

2003 ◽

Vol 14 (5) ◽

pp. 616-620 ◽

Cited By ~ 88

Author(s):

Andreas Beer ◽

André Gahleitner ◽

Anders Holm ◽

Manfred Tschabitscher ◽

Peter Homolka

Keyword(s):

Bone Mineral Density ◽

Bone Mineral ◽

Mineral Density ◽

Quantitative Ct

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Osteonecrosis diagnosed on MR images of the knee: Relationship to reduced bone mineral density determined by high resolution peripheral quantitative CT

Acta Radiologica ◽

10.1080/j.1600-0455.2003.00108.x ◽

2003 ◽

Vol 44 (5) ◽

pp. 525-531 ◽

Cited By ~ 2

Author(s):

M. Zanetti ◽

J. Romero ◽

M. A. Dambacher ◽

J. Hodler

Keyword(s):

Bone Mineral Density ◽

High Resolution ◽

Distal Radius ◽

Bone Mineral ◽

Insufficiency Fracture ◽

Mr Images ◽

Mineral Density ◽

Quantitative Ct ◽

Tibial Condyle ◽

The Mean

Purpose: To evaluate if osteonecrosis diagnosed on MR images of the knee relates to reduced bone mineral density (BMD) and may be caused by an insufficiency fracture. Material and Methods: Thirty-two consecutive patients (8 men, 24 women; age range 27–82 years, mean 62 years) with MR findings of osteonecrosis of the femoral or tibial condyle were prospectively included. Trabecular and cortical BMD were measured with high resolution peripheral quantitative CT in the non-dominant distal radius and the tibia of the involved extremity. One tibia was not measured due to posttraumatic deformity. Results: The mean trabecular BMD of the radius was 81% of the young-adult average peak BMD (range 19–160%). The mean cortical BMD in the radius was 86% (range 63–108%). The mean trabecular BMD in the tibia was 92% (range 28–160%). The mean cortical BMD in the tibia was 86% (range 49–132%). The values of the trabecular bone of the distal radius (tibia) were normal in 11 (15) patients, osteopenic in 12 (4), and osteoporotic in 9 (12), respectively. The cortical bone values of the distal radius (tibia) were normal in 12 (13) patients, osteopenic in 12 (12), and osteoporotic in 8 (6), respectively. Conclusion: Osteoporosis and osteopenia are commonly found in patients with osteonecrosis of the knee as diagnosed on MR images. This indicates that for some patients an insufficiency mechanism may be responsible for the MR findings. However, in the patients with normal bone density other reasons for osteonecrosis may be present.

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Three-Dimensional Characterization of Trabecular Bone Mineral Density of the Distal Radius Utilizing Quantitative Computed Tomography

Hand ◽

10.1177/1558944718789407 ◽

2018 ◽

Vol 15 (1) ◽

pp. 131-139 ◽

Cited By ~ 1

Author(s):

Tyler S. Pidgeon ◽

Katia A. DaSilva ◽

Joseph J. Crisco ◽

Eric C. Johnson ◽

Alison B. Chambers ◽

...

Keyword(s):

Computed Tomography ◽

Bone Mineral Density ◽

Trabecular Bone ◽

Distal Radius ◽

Bone Mineral ◽

Quantitative Computed Tomography ◽

Three Dimensional ◽

Mineral Density ◽

Quantitative Ct ◽

Trabecular Bone Mineral Density

Background: Distal radius (DR) fractures demonstrate patterns of predictable fragments. Bone mineral density (BMD) measurements of these regions of interest (ROIs) may guide more precise treatment. Methods: Computed tomography (CT) scans of the DR of 42 healthy volunteers (23 female) were analyzed using quantitative CT software, measuring BMD within trabecular bone. Seven ROIs were described by alignment with the distal (volar ulnar distal [VUD], dorsal ulnar distal [DUD], volar radial distal [VRD], and dorsal radial distal [DRD]) or proximal (middle ulnar proximal [MUP], middle proximal [MP], and middle radial proximal [MRP]) sigmoid notch. Additional ROIs were the radial styloid (RS) and metadiaphysis (MD). A general estimation equation assessed subject’s BMDs with predictive factors of gender, ROI, and age. The interaction between gender, ROI, and age was included in the model to allow for differences in ROI to vary with gender and/or age. Results: Comparing ROIs within the same gender and, separately, within the same age group revealed significantly higher BMD adjacent to the radioulnar and radiocarpal joints. Male and female individuals aged ≥50 years (mean: 172.7 mg/cm3 ± 6.1) had significantly lower BMD than those aged <50 years (mean: 202.7 mg/cm3 ± 5.8) when all ROIs were considered. Males had higher mean BMD at each ROI compared with females; these differences were significant in 5 of the 9 ROIs: VUD, DUD, DRD, RS, MUP. Conclusions: Trabecular BMD of the DR is highest adjacent to the radioulnar and radiocarpal joints. Female patients and those ≥50 years have lower trabecular BMD.

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