A Rapid and Green Synthesis of 8-Aryl-5,7,7-tricyanoisoquinoline Derivatives at Room Temperature under Solvent-Free and Catalyst-Free Conditions

The synthesis of 3-(aryl(piperidin-1-yl)methyl)-4-hydroxyquinolin-2(1H)-one derivatives via catalyst-free multicomponent reaction is described. The reaction of 4-hydroxyquinolin-2(1H)-one, piperidine, and 4-chlorobenzaldehyde was carried out in different solvents and under solvent-free conditions at room temperature. The best solvent in terms of the yield and reaction time was found to be dichloromethane. Most substituted benzaldehydes reacted with 4-hydroxyquinolin-2(1H)-one and piperidine to afford corresponding products in good-to-excellent yields. Aldehydes with electronwithdrawing groups were more reactive to exhibit higher reaction rates. However, 2-substituted benzaldehydes did not react with 4-hydroxyquinolin-2(1H)-one and piperidine under the reaction condition. Aldehydes bearing a hydroxyl group failed to produce the corresponding products.

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A green and clean pathway: one pot, multicomponent, and visible light assisted synthesis of pyrano[2,3-c]pyrazoles under catalyst-free and solvent-free conditions

New Journal of Chemistry ◽

10.1039/c7nj01688c ◽

2017 ◽

Vol 41 (19) ◽

pp. 11148-11154 ◽

Cited By ~ 15

Author(s):

Bhartendu Pati Tripathi ◽

Anu Mishra ◽

Pratibha Rai ◽

Yogesh Kumar Pandey ◽

Madhulika Srivastava ◽

...

Keyword(s):

Visible Light ◽

Room Temperature ◽

Solvent Free ◽

One Pot ◽

Catalyst Free ◽

Solvent Free Conditions

Visible light mediated, an eco-friendlier synthetic protocol for dihydropyrano[2,3-c]pyrazoles via catalyst-free and solvent-free conditions at room temperature.

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Green Synthesis of Pyrido[2,1-a]isoquinolines and Pyrido[1,2-a]quinolines by Using ZnO Nanoparticles

Synlett ◽

10.1055/s-0036-1591509 ◽

2017 ◽

Vol 29 (04) ◽

pp. 493-496 ◽

Cited By ~ 2

Author(s):

Fatemeh Sheikholeslami-Farahani ◽

Maryam Ghazvini ◽

Somayeh Soleimani-Amiri ◽

Masoomeh Salimifard ◽

Rezvaneh Rostamian

Keyword(s):

Green Synthesis ◽

Zno Nanoparticles ◽

Room Temperature ◽

Solvent Free ◽

Quinoline Derivatives ◽

Zno Nps ◽

Efficient Catalyst ◽

Solvent Free Conditions ◽

Acetylenic Compounds

Pyrido[2,1-a]isoquinoline and pyrido[1,2-a]quinoline derivatives have been produced in good yields by the reaction of isoquinoline or quinoline, activated acetylenic compounds, α-halo ketones, and triphenylphosphine in the presence of ZnO nanoparticles (NPs) as an efficient catalyst under solvent-free conditions at room temperature. The reaction workup is easy, and the products can be readily separated from the reaction mixture. ZnO NPs markedly improved the yield of the product. The catalyst showed significant reusable activity.

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Green Synthesis of Acid Esters from Furfural via Stobbe Condensation

Journal of Chemistry ◽

10.1155/2013/152370 ◽

2013 ◽

Vol 2013 ◽

pp. 1-5 ◽

Cited By ~ 3

Author(s):

Shubhra Banerjee ◽

Ravibabu A. Tayade ◽

Bhagyashree D. Sharma

Keyword(s):

Green Synthesis ◽

Acid Ester ◽

Room Temperature ◽

Condensation Reaction ◽

Dicarboxylic Acids ◽

Solvent Free ◽

Butenoic Acid ◽

Acid Esters ◽

Dimethyl Succinate

Solvent-free Stobbe condensation of furfural1with dimethyl succinate2under anhydrous conditions at room temperature using dry-solid potassium tertiary butoxide gave 3-carbomethoxy, 4-furyl-3-butenoic acid3, which upon methylation followed by Stobbe condensation reaction with different aldehydes and/or ketones under anhydrous conditions at room temperature afforded substituted carbomethoxy acids5a–f. These acid ester products were saponified to the corresponding dicarboxylic acids6a–fwhich are useful in the synthesis of photochromic fulgides.

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