scholarly journals Functional characterization of novel mutations in Ul54 of ganciclovir resistant HCMV strain using structural analysis

2011 ◽  
Vol 5 (9) ◽  
pp. 390-395 ◽  
Author(s):  
Jambulingam Malathi ◽  
Vetrivel Umashankar ◽  
Ravichandran Sathyabaarathi ◽  
Sivashanmugan Muthukumaran ◽  
Murali Ishwarya ◽  
...  
Keyword(s):  
Structural Analysis ◽  
Functional Characterization ◽  
Novel Mutations ◽  
Hcmv Strain

scholarly journals Functional Characterization of a Na+-Coupled Dicarboxylate Carrier Protein from Staphylococcus aureus

2005 ◽  
Vol 187 (15) ◽  
pp. 5189-5194 ◽  
Author(s):  
Jason A. Hall ◽  
Ana M. Pajor
Keyword(s):  
Staphylococcus Aureus ◽  
Structural Analysis ◽  
Transport Properties ◽  
Sequence Homology ◽  
Cytoplasmic Membrane ◽  
Functional Characterization ◽  
Carrier Protein ◽  
Dependent Manner ◽  
Reaction Sequence

ABSTRACT We have cloned and functionally characterized a Na+-coupled dicarboxylate transporter, SdcS, from Staphylococcus aureus. This carrier protein is a member of the divalent anion/Na+ symporter (DASS) family and shares significant sequence homology with the mammalian Na+/dicarboxylate cotransporters NaDC-1 and NaDC-3. Analysis of SdcS function indicates transport properties consistent with those of its eukaryotic counterparts. Thus, SdcS facilitates the transport of the dicarboxylates fumarate, malate, and succinate across the cytoplasmic membrane in a Na+-dependent manner. Furthermore, kinetic work predicts an ordered reaction sequence with Na+ (K 0.5 of 2.7 mM) binding before dicarboxylate (Km of 4.5 μM). Because this transporter and its mammalian homologs are functionally similar, we suggest that SdcS may serve as a useful model for DASS family structural analysis.

scholarly journals Functional characterization of novel mutations in the human cytochrome b gene

2001 ◽  
Vol 9 (7) ◽  
pp. 510-518 ◽  
Author(s):  
Frédéric Legros ◽  
Evi Chatzoglou ◽  
Paule Frachon ◽  
Hélène Ogier de Baulny ◽  
Pascal Laforêt ◽  
...  
Keyword(s):  
Cytochrome B ◽  
Functional Characterization ◽  
Cytochrome B Gene ◽  
Novel Mutations ◽  
Human Cytochrome

scholarly journals Identification and Functional Characterization of Novel Mutations in the Melanocortin-4 Receptor

Obesity Facts ◽  
2010 ◽  
Vol 3 (5) ◽  
pp. 304-311 ◽  
Author(s):  
Sigri Beckers ◽  
Doreen Zegers ◽  
Fenna de Freitas ◽  
Armand V. Peeters ◽  
Stijn L. Verhulst ◽  
...  
Keyword(s):  
Functional Characterization ◽  
Novel Mutations ◽  
Melanocortin 4 Receptor

Functional Characterization of Novel Mutations Affecting Survivin (BIRC5)-Mediated Therapy Resistance in Head and Neck Cancer Patients

2012 ◽  
Vol 34 (2) ◽  
pp. 395-404 ◽  
Author(s):  
Shirley K. Knauer ◽  
Britta Unruhe ◽  
Sarah Karczewski ◽  
Rouven Hecht ◽  
Verena Fetz ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Functional Characterization ◽  
Therapy Resistance ◽  
Novel Mutations

Genetic Analysis of 17 Children with Hunter Syndrome: Identification and Functional Characterization of Four Novel Mutations in the Iduronate-2-Sulfatase Gene

2014 ◽  
Vol 41 (4) ◽  
pp. 197-203 ◽  
Author(s):  
Dimitry A. Chistiakov ◽  
Lyudmila M. Kuzenkova ◽  
Kirill V. Savost'anov ◽  
Anait K. Gevorkyan ◽  
Alexander A. Pushkov ◽  
...  
Keyword(s):  
Genetic Analysis ◽  
Functional Characterization ◽  
Hunter Syndrome ◽  
Novel Mutations

Identification of 34 novel mutations in propionic acidemia: Functional characterization of missense variants and phenotype associations

2018 ◽  
Vol 125 (3) ◽  
pp. 266-275 ◽  
Author(s):  
Ana Rivera-Barahona ◽  
Rosa Navarrete ◽  
Raquel García-Rodríguez ◽  
Eva Richard ◽  
Magdalena Ugarte ◽  
...  
Keyword(s):  
Functional Characterization ◽  
Propionic Acidemia ◽  
Novel Mutations ◽  
Missense Variants
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