scholarly journals Molecular docking analysis of compounds from Justica adhatoda L with glycogen synthase kinase-3 β

2020 ◽  
Vol 16 (11) ◽  
pp. 893-899
Author(s):  
Selvaraj Jayaraman ◽  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Molecular Docking ◽  
Glycogen Synthase ◽  
Analysis Data ◽  
Glycogen Synthase Kinase ◽  
Glycogen Synthase Kinase 3 ◽  
Docking Analysis ◽  
Molecular Docking Analysis

Type 2 diabetes mellitus (T2DM) is linked with Glycogen synthase kinase-3 β.Therefore, it is ofinterest to document molecular docking analysis data of compounds from Justica adhatoda L with glycogen synthase kinase-3 β. We report the binding features of ethambutol, pyrazinamide, stigmasterol and vasicoline with GSK-3 β.

Role of Glycogen synthase kinase-3 in the etiology of Type 2 Diabetes Mellitus: A review

2021 ◽  
Vol 17 ◽  
Author(s):  
Asis Bala ◽  
Susmita Roy ◽  
Debanjana Das ◽  
Venkatesh Marturi ◽  
Chaitali Mondal ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Insulin Receptor ◽  
Glycogen Synthase ◽  
Glycogen Synthase Kinase ◽  
Glycogen Synthase Kinase 3 ◽  
Pharmacological Intervention ◽  
Cellular Transport

: The risk of type 2 diabetes mellitus (T2DM) is increasing abundantly due to lifestyle-related obesity and associated cardiovascular problems. Presently, Glycogen synthase kinase-3 (GSK-3) has gained considerable attention from biomedical scientists to treat diabetes. Phosphorylation of GSK-3 permits a number of cellular activities like regulation of cell signaling, cellular metabolism, cell proliferation and cellular transport. Inhibiting GSK-3 activity by pharmacological intervention has become an important strategy for the management of T2DM. This review focuses on the schematic representation of fundamental GSK-3 enzymology and encompasses the GSK-3 inhibitors as a future therapeutic lead target for the management of T2DM that may significantly regulate insulin sensitivity to insulin receptor, glycogen synthesis and glucose metabolism. The various signaling mechanisms of inhibiting the GSK-3 by describing insulin signaling through Insulin Receptor Substrate (IRS-1), Phosphatidylinositol-3 Kinase (PI3K) and Protein Kinase B (PKB/ AKT) pathways that may hopefully facilitate the pharmacologist to design for antidiabetic drug evaluation model in near future have also been highlighted.

scholarly journals Molecular docking analysis of compounds from Lycopersicon esculentum with the insulin receptor to combat type 2 diabetes

2020 ◽  
Vol 16 (10) ◽  
pp. 748-752
Author(s):  
Anitha Roy ◽  
Keyword(s):  
Type 2 Diabetes ◽  
Molecular Docking ◽  
Lycopersicon Esculentum ◽  
Insulin Receptor ◽  
Bioactive Compounds ◽  
Insulin Receptors ◽  
Docking Analysis ◽  
Molecular Docking Analysis

It is known that tomato (Lycopersicon esculentum) contains bioactive compounds to combat type-2 diabetes. Therefore, it is of interest to document data from the molecular docking analysis of compounds from Lycopersicon esculentum with the insulin receptors to combat type-2 diabetes. We report the binding features of cinnamicacid, chlorogenicacid, gallicacid & glucoside with insulin receptors for further consideration.

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