scholarly journals Correlations between Oxidative DNA Damage, Oxidative Stress and Coenzyme Q10 in Patients with Coronary Artery Disease

2012 ◽  
Vol 9 (8) ◽  
pp. 621-626 ◽  
Author(s):  
Yüksel KAYA ◽  
Ayşegül ÇEBİ ◽  
Nihat SÖYLEMEZ ◽  
Halit DEMİR ◽  
Hamit Hakan ALP ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Coronary Artery Disease ◽  
Dna Damage ◽  
Coronary Artery ◽  
Coenzyme Q10 ◽  
Oxidative Dna Damage ◽  
Artery Disease

scholarly journals A Study of Effects of Addition of Coenzyme Q 10 to High Dose Statins in Patients of Coronary Artery Disease with Special Reference to Oxidative Balance

2017 ◽  
Vol 02 (01) ◽  
pp. 006-013
Author(s):  
Malleswara Dangeti ◽  
Siva Katkam ◽  
Raghu Galla ◽  
Ravi Kiran ◽  
Indrani Garre
Keyword(s):  
Oxidative Stress ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Statin Therapy ◽  
Coenzyme Q10 ◽  
Coenzyme Q ◽  
High Dose ◽  
Plasma Glutathione ◽  
Artery Disease ◽  
Plasma Malondialdehyde

AbstractBackground: Oxidative stress is one of the most potent inductors of endothelial dysfunction and is involved at all stages of atherosclerotic plaque evolution. Statins are 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors and are potent inhibitors of cholesterol biosynthesis. In clinical trials, statins are beneficial in the primary and secondary prevention of coronary heart disease. Statins also possess direct free radical scavenging activity. However, the prooxidant effect of statins has also been reported as statins block the mevalonate pathway and the synthesis coenzyme Q10. This Additional Coenzyme Q10 depletion by statins in patients with coronary artery disease (CAD) may be a critical issue as it may reduce absolute benefits of statins.Objectives: The purpose of this study was to investigate the effects of high dose statins on plasma Malondialdehyde (MDA) levels and plasma glutathione levels in CAD patients who underwent recent PCI and to study whether addition of coenzyme Q10 (100 mg/d) has any additional effect on plasma Malondialdehyde (MDA) levels and plasma glutathione levels in patients already receiving high dose statin therapy.Methods: Twenty-one consecutive patients who underwent percutaneous transluminal coronary angioplasty (PTCA) in Department of Cardiology at our institute were studied. The cases (n = 21) were given high dose statins for first 1 week and then coenzyme Q10 (100 md /day) is added for next 1 week. Plasma Malondialdehyde(MDA) levels and plasma glutathione levels were analyzed at the time of admission before giving statins and at the end of 1 week of statin therapy and again after 1 week of Co-Q therapy.Results: Our results indicate that a relation exists between high plasma Malondialdehyde (MDA) levels and low plasma glutathione levels with coronary artery disease. High dose statins decrease MDA levels and increase plasma glutathione levels, even though they decrease coenzyme q levels in the body. It was also shown that addition of Coenzyme Q10 at 100 mg/d enhances plasma glutathione levels and decreases plasma MDA level still further in patients who have CAD, already receiving high dose statin therapy.Conclusions: Addition of Coenzyme Q10 at 100 mg/d has an additive effect with high dose statins in decreasing oxidative stress. Particularly in light of the excellent tolerance and affordability of this natural physiological compound, supplemental Coenzyme Q10 may emerge as an attractive option in future, and merits evaluation in additional large studies.

Oxidative DNA Damage Is Significantly Correlated With Flow-Mediated Dilation in Patients With Coronary Artery Disease

2008 ◽  
Vol 56 (7) ◽  
pp. 925-930 ◽  
Author(s):  
Selen Yurdakul ◽  
Beste Ozben ◽  
Ahmet Kaya Bilge ◽  
Umit Mutlu Turkoglu ◽  
Selda Arkaya ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Dna Damage ◽  
Coronary Artery ◽  
Endothelial Function ◽  
Oxidative Dna Damage ◽  
Smoking Status ◽  
Significant Negative Correlation ◽  
Flow Mediated Dilation ◽  
Endonuclease Iii ◽  
Artery Disease

BackgroundOxidative DNA damage was increased in patients with coronary artery disease (CAD) and correlated with the severity of the disease. Endothelial dysfunction plays a major role in atherosclerotic process. The aim of this study was to explore a relation between oxidative DNA damage and endothelial function in patients with CAD.MethodsForty patients with CAD and 20 age- and sex-matched healthy controls were included. Endothelial function was assessed by brachial artery ultrasonography. The DNA damage was determined by comet method.ResultsThe DNA damage scores after incubation with repair enzymes were found significantly higher in the patients with CAD (P = 0.04). There was a significant negative correlation between oxidized DNA damage scores and flow-mediated dilation (FMD) measures in the patients with CAD (r = −0.41; P = 0.009). Oxidized DNA damage scores were significantly and independently associated with FMD (standardized β = −0.455; P = 0.009) when adjusted by age, sex, smoking status, blood pressure, and cholesterol levels.ConclusionsThe DNA damage scores were significantly inversely correlated with FMD measures. To our knowledge, this is the first study showing the presence of a relation between DNA damage scores and FMD.Abbreviations: CAD, coronary artery disease, 8-Ohgua, 7, 8-Dihydro-8-oxo-guanine; Endo III, endonuclease III; FMD, flow-mediated dilation; Fpg, formamidopyrimidine glycosylase; NTG, nitroglycerin

Elevated levels of oxidative DNA damage in patients with coronary artery disease

2002 ◽  
Vol 13 (5) ◽  
pp. 269-274 ◽  
Author(s):  
Nicoletta Botto ◽  
Serena Masetti ◽  
Lucia Petrozzi ◽  
Cristina Vassalle ◽  
Samantha Manfredi ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Dna Damage ◽  
Coronary Artery ◽  
Oxidative Dna Damage ◽  
Artery Disease

scholarly journals Assessing Free-Radical-Mediated DNA Damage during Cardiac Surgery: 8-Oxo-7,8-dihydro-2′-deoxyguanosine as a Putative Biomarker

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Linda Turnu ◽  
Alessandro Di Minno ◽  
Benedetta Porro ◽  
Isabella Squellerio ◽  
Alice Bonomi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Coronary Artery ◽  
Oxidative Dna Damage ◽  
Artery Bypass ◽  
Cardiac Surgical Procedures ◽  
Liquid Chromatography Tandem Mass ◽  
Prostaglandin F ◽  
Artery Disease ◽  
Reliable Marker

Coronary artery bypass grafting (CABG), one of the most common cardiac surgical procedures, is characterized by a burst of oxidative stress. 8-Oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodG), produced following DNA repairing, is used as an indicator of oxidative DNA damage in humans. The effect of CABG on oxidative-induced DNA damage, evaluated through the measurement of urinary 8-oxodG by a developed and validated liquid chromatography-tandem mass spectrometry (LC-MS/MS) method in 52 coronary artery disease (CAD) patients, was assessed before (T0), five days (T1), and six months (T2) after CABG procedure. These results were compared with those obtained in 40 subjects with cardiovascular risk factors and without overt cardiovascular disease (CTR). Baseline (T0) 8-oxodG was higher in CAD than in CTR (p=0.035). A significant burst was detected at T1 (p=0.019), while at T2, 8-oxodG levels were significantly lower than those measured at T0 (p<0.0001) and comparable to those found in CTR (p=0.73). A similar trend was observed for urinary 8-iso-prostaglandin F2α (8-isoPGF2α), a reliable marker of oxidative stress. In the whole population baseline, 8-oxodG significantly correlated with 8-isoPGF2α levels (r=0.323, p=0.002). These data argue for CABG procedure in CAD patients as inducing a short-term increase in oxidative DNA damage, as revealed by 8-oxodG concentrations, and a long-term return of such metabolite toward physiological levels.

scholarly journals The Relationship between Coenzyme Q10, Oxidative Stress, and Antioxidant Enzymes Activities and Coronary Artery Disease

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Bor-Jen Lee ◽  
Yi-Chin Lin ◽  
Yi-Chia Huang ◽  
Ya-Wen Ko ◽  
Simon Hsia ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Coronary Artery Disease ◽  
Antioxidant Enzymes ◽  
Coronary Artery ◽  
Coenzyme Q10 ◽  
Control Group ◽  
Enzymes Activities ◽  
Antioxidant Enzymes Activities ◽  
Artery Disease ◽  
The Relationship

A higher oxidative stress may contribute to the pathogenesis of coronary artery disease (CAD). The purpose of this study was to investigate the relationship between coenzyme Q10 concentration and lipid peroxidation, antioxidant enzymes activities and the risk of CAD. Patients who were identified by cardiac catheterization as having at least 50% stenosis of one major coronary artery were assigned to the case group (n=51). The control group (n=102) comprised healthy individuals with normal blood biochemical values. The plasma coenzyme Q10, malondialdehyde (MDA) and antioxidant enzymes activities (catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx)) were measured. Subjects with CAD had significant lower plasma coenzyme Q10, CAT and GPx activities and higher MDA and SOD levels compared to those of the control group. The plasma coenzyme Q10 was positively correlated with CAT and GPx activities and negatively correlated with MDA and SOD. However, the correlations were not significant after adjusting for the potential confounders of CAD with the exception of SOD. A higher level of plasma coenzyme Q10 (≥0.52 μmol/L) was significantly associated with reducing the risk of CAD. Our results support the potential cardioprotective impact of coenzyme Q10.

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