scholarly journals Structure-activity relations of 5,6-cis carbapenem antibiotics and role of factors determining susceptibility of Escherichia coli to .BETA.-lactam antibiotics.

1984 ◽  
Vol 37 (3) ◽  
pp. 218-226 ◽  
Author(s):  
YUKIMASA NOZAKI ◽  
SETSUO HARADA ◽  
KAZUAKI KITANO ◽  
AKIRA IMADA
Keyword(s):  
Escherichia Coli ◽  
Beta Lactam ◽  
Beta Lactam Antibiotics ◽  
Structure Activity ◽  
Structure Activity Relations

scholarly journals Effects of inhibitors of protein synthesis on lysis of Escherichia coli induced by beta-lactam antibiotics.

1996 ◽  
Vol 40 (4) ◽  
pp. 899-903 ◽  
Author(s):  
D G Rodionov ◽  
E E Ishiguro
Keyword(s):  
Escherichia Coli ◽  
Protein Synthesis ◽  
Binding Proteins ◽  
Rapid Development ◽  
Stringent Response ◽  
Beta Lactam ◽  
Penicillin Binding Proteins ◽  
Beta Lactam Antibiotics ◽  
Inhibition Of Protein Synthesis

The role of protein synthesis in ampicillin-induced lysis of Escherichia coli was investigated. The inhibition of protein synthesis through amino acid deprivation resulted in the rapid development of ampicillin tolerance as a consequence of the stringent response, as previously reported. In contrast, inhibition of protein synthesis by use of ribosome inhibitors such as chloramphenicol did not readily confer ampicillin tolerance and, in fact, promoted the development of both stages of the ampicillin-induced lysis process, i.e., (i) an ampicillin-dependent stage which apparently involves the interaction of penicillin-binding proteins with ampicillin and (ii) an ampicillin-independent stage which may represent the events leading to the deregulation of peptidoglycan hydrolase activity. We propose that lysis was facilitated when protein synthesis was inhibited because the production of new penicillin-binding proteins to replace those which were ampicillin inhibited was prevented under these conditions.

Motile Aeromonas as agent of infections of the foot

1995 ◽  
Vol 85 (9) ◽  
pp. 505-508 ◽  
Author(s):  
M Wakabongo
Keyword(s):  
Second Generation ◽  
Antimicrobial Agents ◽  
Third Generation ◽  
Beta Lactam ◽  
Beta Lactam Antibiotics ◽  
Taxonomic Uncertainty ◽  
Post Traumatic ◽  
Third Generation Cephalosporins

Motile Aeromonas infections of the foot are caused mostly by post-traumatic incidence, occurring mostly during summer months. Serious complications such as osteomyelitis and amputation can result if the infections go untreated or are inadequately treated. The role of each species of motile Aeromonas in pathogenesis and response to antimicrobial agents is not well understood because of taxonomic uncertainty. As a group, motile Aeromonas respond well to aminoglycosides, second-generation and third-generation cephalosporins, quinolones, and some beta-lactam antibiotics.

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