Epidemiological Characteristics and Clinical Manifestations of Lyme Borreliosis in Croatia

Purpose To determine the clinical and epidemiological characteristics of abdominal wall endometriosis (AWE), as well as the rate and recurrence factors for the disease. Methods A retrospective study of 52 women with AWE was performed at Universidade Estadual de Campinas from 2004 to 2014. Of the 231 surgeries performed for the diagnosis of endometriosis, 52 women were found to have abdominal wall endometriosis (AWE). The frequencies, means and standard deviations of the clinical characteristics of these women were calculated, as well as the recurrence rate of AWE. To determine the risk factors for disease recurrence, Fisher's exact test was used. Results The mean age of the patients was 30.71 ± 5.91 years. The main clinical manifestations were pain (98%) and sensation of a mass (36.5%). We observed that 94% of these women had undergone at least 1 cesarean section, and 73% had used medication for the postoperative control of endometriosis. The lesion was most commonly located in the cesarean section scar (65%). The recurrence rate of the disease was of 26.9%. All 14 women who had relapsed had surgical margins compromised in the previous surgery. There was no correlation between recurrent AWE and a previous cesarean section (p = 0.18), previous laparotomy (p = 0.11), previous laparoscopy (p = 0.12) and postoperative hormone therapy (p = 0.51). Conclusion Women with previous cesarean sections with local pain or lumps should be investigated for AWE. The recurrence of AWE is high, especially when the first surgery is not appropriate and leaves compromised surgical margins.

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Imbalanced presence of Borrelia burgdorferi s.l. multilocus sequence types in clinical manifestations of Lyme borreliosis

Infection Genetics and Evolution ◽

10.1016/j.meegid.2016.04.019 ◽

2016 ◽

Vol 42 ◽

pp. 66-76 ◽

Cited By ~ 35

Author(s):

E. Claudia Coipan ◽

Setareh Jahfari ◽

Manoj Fonville ◽

G. Anneke Oei ◽

Lodewijk Spanjaard ◽

...

Keyword(s):

Borrelia Burgdorferi ◽

Lyme Borreliosis ◽

Clinical Manifestations ◽

Borrelia Burgdorferi S.L ◽

Sequence Types

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1632. Comparing the epidemiology and clinical characteristics of childhood tuberculosis through active and passive case finding

Open Forum Infectious Diseases ◽

10.1093/ofid/ofaa439.1812 ◽

2020 ◽

Vol 7 (Supplement_1) ◽

pp. S807-S808

Author(s):

Saki Ikeda ◽

Andrea T Cruz ◽

Jeffrey R Starke

Keyword(s):

Clinical Manifestations ◽

Central Nervous System Disease ◽

Data Safety Monitoring Board ◽

Case Finding ◽

Childhood Tuberculosis ◽

Contact Tracing ◽

System Disease ◽

Radiologic Findings ◽

Mediastinal Adenopathy ◽

Epidemiological Characteristics

Abstract Background Childhood tuberculosis can be found via passive case finding (PCF), diagnosing a symptomatic child, and active case finding (ACF), discovering a child through contact tracing. Most high prevalence areas perform PCF, but as ACF is introduced, the clinical and radiologic findings may differ. We compare clinical, radiographic, microbiologic and epidemiological characteristics of children diagnosed through PCF and ACF. Methods A retrospective cohort study of all patients diagnosed with TB from 01/01/2012-12/31/2019 at Texas Children’s Hospital. ACF is TB in a child who had not previously sought care before identified via contact tracing, immigration screening, or screening for incarceration. Severity of disease was based on location of illness, imaging and bacteriology/histopathology. Associations between PCF/ACF and demographics, disease severity, and microbiology were analyzed. Results Of 178 patients, 80 (45%) were diagnosed via ACF. ACF patients were more likely to be US-born (OR: 2.29, [95% Confidence interval (CI): 1.12-4.67]) and younger (mean 6.18 vs 8.84 years, p= 0.016). Only 2.5% of ACF patients had extrapulmonary disease, compared to 45% of the PCF group (p< 0.0001). All 14 severe extrathoracic cases were in the PCF group (10 central nervous system disease, 3 ocular disease, 1 spondylitis). Fewer patients in the ACF group had severe intrathoracic findings (11% vs 39%, p< 0.001): miliary disease (0% vs 10%, p=0.006), cavity (1% vs 9%, p=0.04), and multilobar involvement (7.5% vs 22.4%, p=0.006). ACF patients had more hilar/mediastinal adenopathy (OR: 2.51, [CI: 1.34-3.72], p=0.004). ACF patients were less often cultured (38% vs 89%, p< 0.0001) and had less microbiological confirmation by cultures or PCR (21% vs 52%, p=< 0.0001). Conclusion Patients in the ACF group were younger, had less severe clinical manifestations, and had almost no extrathoracic disease. Clinicians need to be aware that the common clinical and radiographic presentations in children differ between PCF and ACF. Disclosures Jeffrey R. Starke, MD, Otsuka Pharmaceuticals (Other Financial or Material Support, Member, Data Safety Monitoring Board)

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Paediatric visceral leishmaniasis: a retrospective study on clinical manifestations, demographic features and laboratory findings of hospitalised cases in Iran between 2006 and 2016

Tropical Doctor ◽

10.1177/0049475518811513 ◽

2018 ◽

Vol 49 (1) ◽

pp. 59-61 ◽

Cited By ~ 1

Author(s):

Manijeh Nourian ◽

Aliehsan Heidari ◽

Saleheh Tajali ◽

Erfan Ghasemi ◽

Mehdi Mohebali ◽

...

Keyword(s):

Retrospective Study ◽

Visceral Leishmaniasis ◽

Clinical Manifestations ◽

Laboratory Findings ◽

Neglected Disease ◽

Paediatric Hospital ◽

Geographical Regions ◽

Epidemiological Characteristics ◽

Demographic Features

Visceral leishmaniasis (VL) is a neglected disease. Our retrospective study describes 38 clinical and epidemiological characteristics of VL in patients admitted to a paediatric hospital in Tehran, Iran, who came from different geographical regions, indicating that the disease has spread to most parts of the country. Some 76.3% of the children documented suffered with symptoms of the disease for two months before admission.

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Clinical and Epidemiological Characteristics of Parvoviral Infection (B-19) in Kyrgyz Republic

Bulletin of Science and Practice ◽

10.33619/2414-2948/61/20 ◽

2020 ◽

Vol 6 (12) ◽

pp. 218-224

Author(s):

S. Chechetova ◽

E. Khalupko ◽

R. Kadyrova ◽

Z. Dzholbunova ◽

A. Mambetova

Keyword(s):

Clinical Manifestations ◽

Kyrgyz Republic ◽

Present Stage ◽

Epidemiological Factors ◽

Epidemiological Characteristics

The paper presents the clinical and epidemiological characteristics of parvovirus infection (B-19) in Kyrgyzstan at the present stage. The main epidemiological factors identified in the process of collecting anamnesis are considered. The most typical clinical manifestations for this infection were also identified

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Characteristics and Prognosis of Autoimmune Encephalitis in the East of China: A Multi-Center Study

Frontiers in Neurology ◽

10.3389/fneur.2021.642078 ◽

2021 ◽

Vol 12 ◽

Author(s):

Shan Qiao ◽

Huai-kuan Wu ◽

Ling-ling Liu ◽

Ran-ran Zhang ◽

Mei-ling Wang ◽

...

Keyword(s):

Poor Prognosis ◽

Disease Onset ◽

Clinical Manifestations ◽

Brain Magnetic Resonance Imaging ◽

Autoimmune Encephalitis ◽

Post Discharge ◽

Disturbance Of Consciousness ◽

Imaging Results ◽

Epidemiological Characteristics

Objective: This study aimed to investigate epidemiological characteristics, clinical manifestations, and long-term outcomes of patients with autoimmune encephalitis (AE) in the east of China.Methods: From January 2015 to December 2019, 226 potential AE patients were recruited from five clinical centers, and a total of 185 patients who met the diagnostic criteria were included in the study. We retrospectively reviewed clinical features, auxiliary examinations, details of treatments, and outcomes of AE, and identified risk factors of poor prognosis. Modified Rankin Scale scores were used to evaluate neurological function, and scores of 3–6 indicated a poor-prognosis.Results: Patients with five main subtypes of AE were enrolled in the study, as follows: anti-NMDAR (79), anti-LGI1 (55), anti-CASPR2 (30), anti-GABABR (16), and anti-AMPAR (5). Among 185 patients, 58.38% (108/185) were male and 41.62% (77/185) were female. The median age at disease onset was 41 years (interquartile range, 17–62). The most common clinical manifestations of AE were seizures (146, 78.92%) and memory deficit (123, 66.49%). A total of 95 (51.35%) patients had abnormal brain magnetic resonance imaging results. Electroencephalographic findings were abnormal in 131 (70.81%) patients, and 168 (90.81%) and 26 (14.05%) patients were treated with first- and second-line immunotherapies, respectively. All surviving patients were followed-up for at least 1 year (range 12–36 months). Good clinical outcomes were achieved in 117 (63.24%), while 68 (36.76%) patients had a poor prognosis. Further, 33 (17.84%) patients relapsed and 10 (5.41%) died within 1 year post-discharge. Older patients tended to have a poorer prognosis, and the occurrence of mental behavioral disorders, movement disorders, disturbance of consciousness, central hypoventilation, and tumors were overrepresented in the poor-prognosis group.Conclusions: AE is a treatable disease, and most patients have a good prognosis. There are differences in the clinical manifestations of patients with different AE subtypes. Some with AE will relapse, and long-term follow-up is of great significance for further research.

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Modern Epidemiological Features of Lyme-borreliosis and Diagnostic Criteria of «Minor» Forms of Myocarditis

Family Medicine ◽

10.30841/2307-5112.6.2016.249523 ◽

2016 ◽

pp. 94-97

Author(s):

Iryna Budaeva ◽

Heorhii Revenko ◽

Liubov Kodola ◽

Svitlana Ryasik

Keyword(s):

Diagnostic Criteria ◽

Lyme Borreliosis ◽

Epidemiological Features ◽

Heart Involvement ◽

Working Age ◽

Working Age Population ◽

Epidemiological Characteristics

This paper shows the epidemiological characteristics of Lyme-borreliosis in Dnipropetrovsk region, which presents urbanic environment. The greatest incidence of the disease was determined in working age population. The possibility of heart involvement in the «minor» forms is proved; the later are diagnosed with the means of ECG and CFK-MB evaluation.

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Lyme borreliosis

Oxford Textbook of Rheumatology ◽

10.1093/med/9780199642489.003.0101_update_002 ◽

2013 ◽

pp. 772-777

Author(s):

Andreas Krause ◽

Volker Fingerle

Keyword(s):

Lyme Borreliosis ◽

Erythema Migrans ◽

Clinical Manifestations ◽

Lyme Arthritis ◽

Symptomatic Therapy ◽

Positive Serology ◽

Antibiotic Resistant ◽

Acrodermatitis Chronica Atrophicans ◽

Rapid Healing ◽

The Central Nervous System

Lyme borreliosis (LB) is a multisystem infectious disease caused by the tick-borne spirochete Borrelia burgdorferi. The most frequent clinical manifestations include erythema migrans, meningoplyneuritis, and arthritis. Diagnosis of LB is made on clinical grounds and usually supported by a positive serology. Early diagnosis and treatment almost always leads to a rapid healing of the disease. However, in late manifestations gradual remission of symptoms may take several weeks to months. In rare cases, the pathogen can persist for many years or induce a persisting immunopathological response that may cause acrodermatitis chronica atrophicans, chronic neuroborreliosis of the central nervous system, or antibiotic resistant Lyme arthritis. However, even these chronic manifestations usually slowly regress after thorough antibiotic and symptomatic therapy, although in part with irreversible organ defects.

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Lyme borreliosis

10.1093/med/9780199642489.003.0101 ◽

2013 ◽

Cited By ~ 1

Author(s):

Andreas Krause ◽

Volker Fingerle

Keyword(s):

Lyme Borreliosis ◽

Erythema Migrans ◽

Clinical Manifestations ◽

Lyme Arthritis ◽

Symptomatic Therapy ◽

Positive Serology ◽

Antibiotic Resistant ◽

Acrodermatitis Chronica Atrophicans ◽

Rapid Healing ◽

The Central Nervous System

Lyme borreliosis (LB) is a multisystem infectious disease caused by the tick-borne spirochete Borrelia burgdorferi. The most frequent clinical manifestations include erythema migrans, meningoplyneuritis, and arthritis. Diagnosis of LB is made on clinical grounds and usually supported by a positive serology. Early diagnosis and treatment almost always leads to a rapid healing of the disease. However, in late manifestations gradual remission of symptoms may take several weeks to months. In rare cases, the pathogen can persist for many years or induce a persisting immunopathological response that may cause acrodermatitis chronica atrophicans, chronic neuroborreliosis of the central nervous system, or antibiotic resistant Lyme arthritis. However, even these chronic manifestations usually slowly regress after thorough antibiotic and symptomatic therapy, although in part with irreversible organ defects.

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