scholarly journals Peer Review #2 of "A retrospective study on the prognostic value of preoperative C-reactive protein to albumin ratio in patients with oral cavity squamous cell carcinoma (v0.2)"

2020 ◽  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Retrospective Study ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Peer Review ◽  
Squamous Cell ◽  
Prognostic Value ◽  
C Reactive Protein ◽  
Albumin Ratio ◽  
Reactive Protein

scholarly journals Prognostic value of the C-reactive protein/albumin ratio in patients with laryngeal squamous cell carcinoma

2017 ◽  
Vol Volume 10 ◽  
pp. 879-884 ◽  
Author(s):  
Shi-tong Yu ◽  
Zhiwei Zhou ◽  
Qian Cai ◽  
Faya Liang ◽  
Ping Han ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Prognostic Value ◽  
Laryngeal Squamous Cell Carcinoma ◽  
C Reactive Protein ◽  
Albumin Ratio ◽  
Reactive Protein

scholarly journals A retrospective study on the prognostic value of preoperative C-reactive protein to albumin ratio in patients with oral cavity squamous cell carcinoma

PeerJ ◽  
2020 ◽  
Vol 8 ◽  
pp. e9361
Author(s):  
Ku-Hao Fang ◽  
Chia-Hsuan Lai ◽  
Cheng-Ming Hsu ◽  
Ethan Huang ◽  
Ming-Shao Tsai ◽  
...  
Keyword(s):  
Overall Survival ◽  
Squamous Cell Carcinoma ◽  
Retrospective Study ◽  
Oral Cavity ◽  
Prognostic Value ◽  
Clinicopathological Factors ◽  
C Reactive Protein ◽  
Albumin Ratio ◽  
Reactive Protein ◽  
Kaplan Meier

Background Although the C-reactive protein-to-albumin ratio (CAR) can predict poor outcomes in assorted cancers, its prognostic value in oral cavity squamous cell carcinoma (OSCC) remains unclear. We explored the value of preoperative CAR in predicting clinical outcomes in OSCC patients treated with radical surgery. Methods All the recommended cutoff values were defined analyzing receiver operating characteristic curves or overall survival (OS). Dichotomization was performed on the basis of optimal CAR cutoff, and we compared the clinicopathological features between groups. Kaplan–Meier analysis was also performed to compare OS curves between the two groups. Univariate and multivariate analyses using the Cox proportional hazards model were conducted to find the clinical characteristics that were most closely correlated with disease free survival (DFS) and overall survival (OS). A nomogram incorporated CAR and several clinicopathological factors was established to predict prognosis and its accuracy was evaluated using concordance index (c-index). Results In this retrospective study, a total of 326 patients with newly diagnosis of OSCC and received primary surgery between 2008 and 2017 were enrolled. Through the executed ROC curve analyses, the optimal CAR cutoff derived was 0.195 (area under the curve = 0.718, p < 0.001), with this cutoff exhibiting a discrimination ability superior to that of other inflammation-based prognostic scores after comparing the area under curves. Multivariate analysis demonstrated that CAR (≥0.195/<0.195) was associated with OS (hazard ratio 3.614; 95% CI [1.629–8.018]; p = 0.002) and DFS (hazard ratio 1.917; 95% CI [1.051–3.863]; p = 0.029). Kaplan–Meier analysis and log rank test revealed a significant difference in DFS and OS curves between patients with low CAR (<0.195) and those with high CAR (≥0.195; both p < 0.001). The c-index of the nomogram based on TNM system alone was 0.684 and could be increased to 0.801 if CAR and other clinicopathological factors were included. Conclusions Preoperative CAR could constitute an independent prognostic indicator for OS and DFS prediction in OSCC patients treated with curative surgery. The established nomogram that incorporated CAR and prognostic factors might increase the accuracy of prognostic prediction for patients with OSCC.

Preoperative high c-reactive protein/albumin ratio is a poor prognostic factor of oral squamous cell carcinoma

2019 ◽  
Vol 15 (19) ◽  
pp. 2277-2286 ◽  
Author(s):  
Qiuju Wang ◽  
Xiaoyu Song ◽  
Yanzhen Zhao ◽  
Qiao He ◽  
Min Shi ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Prognostic Factor ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
C Reactive Protein ◽  
Poor Prognostic Factor ◽  
Albumin Ratio ◽  
Reactive Protein
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