scholarly journals Effect of Portal Vein Chemotherapy on Liver Metastasis after Surgical Resection of Colorectal Cancer

2012 ◽  
Vol 13 (9) ◽  
pp. 4699-4701 ◽  
Author(s):  
Dong-Sheng Yu ◽  
Ying Li ◽  
Xin-En Huang ◽  
Yan-Yan Lu ◽  
Xue-Yan Wu ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Liver Metastasis ◽  
Portal Vein ◽  
Surgical Resection

Timing of Surgical Resection for Curative Colorectal Cancer with Liver Metastasis

2017 ◽  
Vol 25 (1) ◽  
pp. 32-37 ◽  
Author(s):  
Shahzad M. Ali ◽  
Timothy M. Pawlik ◽  
Miguel A. Rodriguez-Bigas ◽  
John R.T. Monson ◽  
George J. Chang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Liver Metastasis ◽  
Surgical Resection

scholarly journals The effect of preoperative chemotherapy on liver regeneration after portal vein embolization/ligation or liver resection in patients with colorectal liver metastasis: a systematic review protocol

2020 ◽  
Vol 9 (1) ◽  
Author(s):  
Mihai-Calin Pavel ◽  
Raquel Casanova ◽  
Laia Estalella ◽  
Robert Memba ◽  
Erik Llàcer-Millán ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Systematic Review ◽  
Liver Resection ◽  
Liver Metastasis ◽  
Neoadjuvant Chemotherapy ◽  
Portal Vein ◽  
Liver Failure ◽  
Liver Regeneration ◽  
Meta Analysis ◽  
Number Of Cycles

Abstract Introduction Liver resection (LR) in patients with liver metastasis from colorectal cancer remains the only curative treatment. Perioperative chemotherapy improves prognosis of these patients. However, there are concerns regarding the effect of preoperative chemotherapy on liver regeneration, which is a key event in avoiding liver failure after LR. The primary objective of this systematic review is to assess the effect of neoadjuvant chemotherapy on liver regeneration after (LR) or portal vein embolization (PVE) in patients with liver metastasis from colorectal cancer. The secondary objectives are to evaluate the impact of the type of chemotherapy, number of cycles, and time between end of treatment and procedure (LR or PVE) and to investigate whether there is an association between degree of hypertrophy and postoperative liver failure. Methods This meta-analysis will include studies reporting liver regeneration rates in patients submitted to LR or PVE. Pubmed, Scopus, Web of Science, Embase, and Cochrane databases will be searched. Only studies comparing neoadjuvant vs no chemotherapy, or comparing chemotherapy characteristics (bevacizumab administration, number of cycles, and time from finishing chemotherapy until intervention), will be included. We will select studies from 1990 to present. Two researchers will individually screen the identified records, according to a list of inclusion and exclusion criteria. Primary outcome will be future liver remnant regeneration rate. Bias of the studies will be evaluated with the ROBINS-I tool, and quality of evidence for all outcomes will be determined with the GRADE system. The data will be registered in a predesigned database. If selected studies are sufficiently homogeneous, we will perform a meta-analysis of reported results. In the event of a substantial heterogeneity, a qualitative systematic review will be performed. Discussion The results of this systematic review may help to better identify the patients affected by liver metastasis that could present low regeneration rates after neoadjuvant chemotherapy. These patients are at risk to develop liver failure after extended hepatectomies and therefore are not good candidates for such aggressive procedures. Systematic review registration PROSPERO registration number: CRD42020178481 (July 5, 2020).

scholarly journals Macroscopic portal vein tumor thrombi of liver metastasis from colorectal cancer

2008 ◽  
Vol 16 (1) ◽  
pp. 90-93 ◽  
Author(s):  
Takuichi Oikawa ◽  
Tadatoshi Takayama ◽  
Shunji Okada ◽  
Tomohisa Kamo ◽  
Masahiko Sugitani ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Liver Metastasis ◽  
Portal Vein ◽  
Tumor Thrombi

scholarly journals The histological growth patterns of colorectal cancer liver metastasis are associated with disease progression post portal vein embolization

HPB ◽  
2017 ◽  
Vol 19 ◽  
pp. S59 ◽  
Author(s):  
E. Simoneau ◽  
P. Vermeulen ◽  
G. Van den Eynden ◽  
A. Reynolds ◽  
S. Petrillo ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Liver Metastasis ◽  
Portal Vein ◽  
Disease Progression ◽  
Portal Vein Embolization ◽  
Growth Patterns ◽  
Colorectal Cancer Liver Metastasis
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