scholarly journals Inhibitory Effect of Benzyl Isothiocyanate on Proliferation in vitro of Human Glioma Cells

2013 ◽  
Vol 14 (4) ◽  
pp. 2607-2610 ◽  
Author(s):  
Yu Zhu ◽  
Jun-Xue Zhuang ◽  
Qin Wang ◽  
Hai-Yan Zhang ◽  
Ping Yang
2014 ◽  
Vol 120 (2) ◽  
pp. 273-281 ◽  
Author(s):  
Chun-Yuan Cheng ◽  
Ying-Erh Chou ◽  
Chung-Po Ko ◽  
Shun-Fa Yang ◽  
Shu-Ching Hsieh ◽  
...  

Data in Brief ◽  
2016 ◽  
Vol 9 ◽  
pp. 667-672 ◽  
Author(s):  
Gong-Jhe Wu ◽  
Chien-Ju Lin ◽  
Yung-Wei Lin ◽  
Ruei-Ming Chen

1997 ◽  
Vol 20 (4) ◽  
pp. 355-365 ◽  
Author(s):  
Shravan K. Chintala ◽  
Sanjeeva Mohanam ◽  
Yoshinori Go ◽  
Boyapati Venkaiah ◽  
Raymond Sawaya ◽  
...  

2015 ◽  
Vol 10 (4) ◽  
pp. 966
Author(s):  
Ji-Heng Hao ◽  
Dian-Feng Hu ◽  
Li-Mei Mao ◽  
Shi-Gang Zhang ◽  
Ji-Yue Wang ◽  
...  

<p class="Abstract">The present study was performed to investigate the effect of 2-fluorobenzaldehyde retinoic acid conjugate on activation of STAT3 pathway in human glioma cells. The results revealed that the compound exhibited inhibitory effect on the activation of STAT3 induced constitutively and by interleukin-6. The inhibitory effect on STAT3 activation was found to be concentration- and time-dependent. In U373 glioma cells, 2-fluorobenzaldehyde retinoic acid conjugate treatment caused a significant enhancement in the expression of proapoptotic proteins like Bax and Bak. Its treatment inhibited the expression of genes including, cyclin D1, Bcl-2, Bcl-xL, survivin, Mcl-1, and vascular endothelial growth factor (VEGF) in U373 glioma cells. Furthermore, the conjugate inhibited proliferation, induced apoptosis and caused accumulation of cells in G1-G0 phase of cell cycle. Thus, 2-fluorobenzaldehyde retinoic acid conjugate acts as a potent inhibitor of STAT3 activation that can be promising importance for the prevention and treatment of gliomas.</p><p> </p>


2014 ◽  
Vol 35 (9) ◽  
pp. 1199-1206 ◽  
Author(s):  
Yun-wei Ou ◽  
Zi-tong Zhao ◽  
Chuan-yue Wu ◽  
Bai-nan Xu ◽  
Yong-mei Song ◽  
...  

2016 ◽  
Vol 42 (4) ◽  
pp. 997-1005 ◽  
Author(s):  
Shi-Jun Zhao ◽  
Xian-Jun Wang ◽  
Qing-Jian Wu ◽  
Chao Liu ◽  
Da-Wei Li ◽  
...  

1996 ◽  
Vol 32 (5) ◽  
pp. 868-871 ◽  
Author(s):  
S.L. Maidment ◽  
A. Merzak ◽  
S. Koochekpour ◽  
H.K. Rooprai ◽  
G.J. Rucklidge ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document